Mansoa Alliacea is a native plant from Amazonian basin and has great ancestral value for the local communities. M. alliacea is a traditional medicine for healers and shamans and has multiple uses due to the presence of several chemical constituents with important pharmacological properties. Plant derivate are used as: antiseptic, diuretic, analgesic, antipyretic. Folk medicine is related also to the treatment of many diseases such as: reduction of blood pressure against atherosclerosis, arthritis and rheumatism. Researches have also been proven an appreciable antioxidant property, which revalue it for cosmetic purposes.  Chemical composition includes: alidil-sulfoxide, allylindyloxide, allina, allein, allicin, disulfide, propylallyl, divinyl sulfide, diallyl sulfide, dimethyl sulfide, daucosterol, beta-sitosterol, fucosterol, stigmasterol, iridoides and isothiocyanates, naphthoquinones, alkaloids, saponins, flavones, vitamin E, vitamin C and minerals such as chromium and selenium. The present review includes ethnobotanical and pharmacological data that are related to the chemical composition of M. alliacea species.