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Conference Schedule

The program of the 2nd International Symposium on Frontiers in Molecular Science 'Non-Coding RNAs and Epigenetics in Cancer', Basel, is now available in the abstract book (last update June, 15). 


Wednesday 21 June 2017

Thursday 22 June 2017

Friday 23 June 2017

Morning

The Biology of ncRNAs

Prof. Reuven Agami
Prof. Amy Pasquinelli

Bioinformatics of ncRNAs

Prof. Isidore Rigoutsos
Prof. Mihaela Zavolan

ncRNA Technologies

Prof. Thomas Schmittgen
Prof. Jo Vandesompele

Coffee Break

Coffee Break

Coffee Break

The Biology of ncRNAs

Prof. Qihong Huang
Prof. Sven Diederichs

Bioinformatics of ncRNAs

Prof. John S. Mattick
Prof. Ulf Andersson Orom
Prof. Manel Esteller

ncRNA Technologies

Prof. Maite Huarte Martinez

Lunch and Poster Session

Lunch and Poster Session

Concluding Remarks

  Afternoon

Translational Applications
of ncRNAs as Biomarkers

Prof. Carlo Croce
Prof. Menashe Bar-Eli

ncRNA Therapeutics

Prof. Frank J. Slack
Prof. George A. Calin

Coffee Break

Coffee Break

Translational Applications
of ncRNAs as Biomarkers

Prof. Helge Grosshans
Prof. Fabbri Muller
Prof. Manuela Ferracin

ncRNA Therapeutics

Prof. Massimo Negrini
Prof. Kalpana Ghoshal

Conference Dinner 

Session Start

Wednesday 21 June 2017: 08:30 - 13:20 / 14:20 - 18:10
Thursday 22 June 2017: 09:00 - 13:20 / 14:20 - 18:10
Friday 23 June 2017: 09:00 - 13:20

Detailed Program

Day 1: Wednesday 21 June 2017

07:30–08:30 Check-in
08:30–08:45 Welcome – Conradin Cramer
08:45–09:00 Introduction – George A. Calin

09:00–13:20 Session 1: The Biology of ncRNAs – Sponsored by Arraystar Arraystar
Session Chairs: Amy Pasquinelli and Reuven Agami

09:00–09:30 Reuven Agami – Functional Genetic Screens of Regulatory DNA Elements
09:30–10:00 Amy Pasquinelli – Elucidating the Dark Side of the MicroRNA
10:00–10:20 Joost Kluiver – ZDHHC11 and ZDHHC11B are Novel Critical Components of the Oncogenic miR-150-MYBnetwork in Burkitt Lymphoma
10:20–10:40 Eleonora Candi – Ultra-Conserved Non-Coding Transcript T-UC291 Controls Somatic Tissue Differentiation by Interfering with ACTL6A
10:40–11:00 Carmen Jeronimo – A Multiplatform Approach Identifies miR-152 as a Novel Epigenetically Downregulated microRNA in Prostate Cancer

11:00–11:40 Coffee Break

11:40–12:10 Qihong Huang – Lost in Translation: Long Non-coding RNAs in Metastasis
12:10–12:40 Sven Diederichs – MALAT1 and Beyond - Long Non-coding RNAs in Lung Cancer
12:40–13:00 Daniela Zeitler – Hyper-phosphorylation of Argonaute Proteins Affects mRNA Binding and is Essential for microRNA-guided Gene Silencing
13:00–13:20 Jelena Kresoja-Rakic – lncRNA RP11-334E6.12 expression is highly correlated with increased THY-1 expression in chemoresistant primary mesothelioma cells

13:20–14:30 Lunch and Poster Session

14:30–18:20 Session 2: Translational Applications of ncRNAs as Biomarkers
Session Chairs: Carlo Croce and Menashe Bar-Eli

14:30–15:00 Carlo Croce – MicroRNA Dysregulation to Identify Therapeutic Target Combinations for Chronic Lymphocytic Leukemia
15:00–15:30 Menashe Bar-Eli – RNA Editing and Melanoma Metastasis
15:30–15:50 Stefan Eichmüller – miRNAs Modulating Melanoma Cell Invasion

15:50–16:30 Coffee Break

16:30–17:00 Helge Grosshans – Noncoding RNA Function and Regulation in Animal Development
17:00–17:30 Fabbri Muller – Role of Exosomal miRNAs in the Biology of the Tumor Microenvironment
17:30–18:00 Manuela Ferracin – Epigenetic Biomarkers of Prognosis in Stage IIA Colon Cancer
18:00–18:20 Dror Avni – Alterations of MicroRNAs Throughout the Malignant Evolution of Cutaneous Squamous Cell Carcinoma: The Role of miR-497 in Epithelial to Mesenchymal Transition of Keratinocytes 

Day 2: Thursday 22 June 2017

09:00–13:10 Session 3: Bioinformatics and ncRNAs World
Session Chairs: Isidore Rigoutsos and John S. Mattick

09:00–09:30 Isidore Rigoutsos – Transcriptomic Heterogeneity: Known and Novel Short Non-coding Regulatory RNAs that Depend on Sex, Population Origin, Tissue, and Disease
09:30–10:00 Mihaela Zavolan – The 3' UTR Landscape of Human Cancers
10:00–10:20 Giovanna Brancati – Fatal Imperfections: Determinants of miRNA Target Specificity
10:20–10:40 Francisco J. Enguita – miRNAtools: Advanced Training Using the miRNA Web of Knowledge
10:40–11:00 Rory Johnson – Cancer Driver Long Noncoding RNA Discovery in the Pan-Cancer Analysis of Whole Genomes (PCAWG) Collaboration

11:00–11:40 Coffee Break

11:40–12:10 John S. Mattick – Exons are the modular unit of structure-function in regulatory RNAs
12:10–12:40 Ulf Andersson Orom – Chromatin-Release Is Important for Long NcRNA Function
12:40–13:10 Manel Esteller – Epigenetics and Epitranscriptomics of Non-Coding RNAs in Human Cancer

13:10–14:10 Lunch and Poster Session

14:10–17:50 Session 4: ncRNA Therapeutics
Session Chairs: Frank J. Slack and Massimo Negrini

14:10–14:40 Frank J. Slack – MicroRNA-Based Therapeutics in Cancer
14:40–15:10 George A. Calin – About Chomsky, Non-Coding RNA Structure and Cancer Patient's Treatment
15:10–15:30 Aniello Russo – Role of miR-125a in Hepatic Carcinogenesis

15:30–16:10 Coffee Break

16:10–16:40 Massimo Negrini – Multiple Approaches for miRNA-based Therapies of Cancer
16:40–17:10 Kalpana Ghoshal – Transcriptome-Wide Mapping of the miR-122 Targetome Revealed its Mechanistic Role in the Maintenance of Liver Homeostasis and Suppressing Hepatocarcnogenesis
17:10–17:30 Silvia Catuogno – Development of RNA Aptamers for Targeting B-cell-derived Malignancies
17:30–17:50 Alva Rani James – A Specific long non-coding RNA Expression Signature Defines the Philadelphia-like B-cell Acute Lymphoblastic Leukemia Subtype

19:00 Conference Dinner

Day 3: Friday 23 June 2017

09:00–13:20 Session 5: ncRNA Technologies
Session Chairs: Thomas Schmittgen and Manel Esteller 

09:00–09:30 Thomas Schmittgen – microRNAs Shape Plasticity of Pancreatic Acini
09:30–10:00 Jo Vandesompele – Tools for lncRNA Research in Cancer
10:00–10:20 Britta Skawran – The microRNA-449 Family Inhibits TGF-β-mediated Liver Cancer Cell Migration by Targeting SOX4
10:20–10:40 Jörg Krummheuer – An Improved Algorithm for Antisense LNA™ GapmeR Design
10:40–11:00 Mattia Boeri – High Risk Plasma microRNA Signature is Associated with an Immune-related Gene Expression Profile of Lung Tumour Tissues

11:00–11:40 Coffee Break

11:40–12:00 Martin Pichler – MicroRNA-196 Influence Metastases Formation in Colorectal Cancer through Regulation of HOXB and GALNT Gene Expression
12:00–12:30 Maite Huarte Martinez – Functional long Noncoding RNAs in Cancer Pathways
12:30–12.50 Enrique Fuentes-Mattei – Plasma Viral miRNAs as Targeted-biomarkers of Occult Viral Infections Prevalence and Sepsis Aggressiveness
12:50–13:10 Paola Parrella – Stepwise Analysis of MIR9 Loci Identifies miR-9-5p to be Involved in Oestrogen Regulated Pathways in Breast Cancer Patients

13:10 Concluding Remarks

Conference Speakers

Session 1: The Biology of ncRNAs - Sponsored by Arraystar

Prof. Reuven Agami - Functional Genetic Screens of Regulatory DNA Elements
Netherlands Cancer Institute - NKI Amsterdam, The Netherlands

Prof. Amy Pasquinelli - Elucidating the Dark Side of the MicroRNA
Division of Biological Sciences, University of California, USA

Prof. Qihong Huang - Lost in Translation: Long Non-Coding RNAs in Metastasis 
Tumor Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, USA

Prof. Sven Diederichs - MALAT1 and Beyond - Long Non-Coding RNAs in Lung Cancer
Division Head RNA Biology & Cancer, DKFZ - Deutsches Krebsforschungszentrum, Germany 

Session 2: Translational Applications of ncRNAs as Biomarkers

Prof. Carlo Croce - MicroRNA Dysregulation to Identify Therapeutic Target Combinations for Chronic Lymphocytic Leukemia 
Department of Cancer Biology and Genetics, The Ohio State University, USA

Prof. Menashe Bar-Eli - RNA Editing and Melanoma Metastasis 
Department of Cancer Biology, The University of Texas, MD Anderson Cancer Center, USA

Prof. Helge Grosshans - Non-Coding RNA Function and Regulation in Animal Development
Friedrich Miescher Institute for Biomedical Research (FMI) Basel, Switzerland

Prof. Fabbri Muller - Role of Exosomal miRNAs in the Biology of the Tumor Microenvironment 
Pediatrics and Molecular Microbiology and Immunology, Children's Hospital Los Angeles, University of Southern California, USA

Prof. Manuela Ferracin - Epigenetic Biomarkers of Prognosis in Stage IIA Colon Cancer
Department of Specialised, Experimental, and Diagnostic Medicine, University of Bologna, Italy

Session 3: Bioinformatics of ncRNAs

Prof. Isidore Rigoutsos - Transcriptomic Heterogeneity: Known and Novel Short Non-Coding Regulatory RNAs that Depend on Sex, Population Origin, Tissue, and Disease 
Director Computational Medicine Center, Thomas Jefferson University

Prof. Mihaela Zavolan - The 3' UTR Landscape of Human Cancers 
Professor in Computational Biology/Genomics, Biozentrum, University of Basel, Switzerland

Prof. John S. Mattick - Exons are the Modular Unit of Structure-Function in Regulatory RNAs
Institute Director and Head, RNA Biology and Plasticity Laboratory Senior Principal Research Fellow, Garvan Institute of Medical Research, University of New South Wales, Sydney, Australia 

Prof. Ulf Andersson Orom - Chromatin-Release Is Important for Long ncRNA Function
Long non-coding RNA Research Group, Max Planck Institute for Molecular Genetics, Germany

Prof. Manel Esteller - Epigenetics and Epitranscriptomics of Non-Coding RNAs in Human Cancer
Leader of the Cancer Epigenetics Group, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain

Session 4: ncRNA Therapeutics

Prof. Frank J. Slack - MicroRNA-Based, Therapeutics in Cancer
Professor, Pathology, Harvard Medical School, Professor, Pathology, Beth Israel Deaconess Medical Center, Boston, USA

Prof. George A. Calin -  About Chomsky, Non-Coding RNA Structure and Cancer Patient's Treatment
The University of Texas, MD Anderson Cancer Center, Houston, TX, USA 

Prof. Massimo Negrini - Multiple Approaches for miRNA-based Therapies of Cancer
Department of Morphology Surgery and Experimental Medicine, University of Ferrara, Italy

Prof. Kalpana Ghoshal - Transcriptome-Wide Mapping of the miR-122 Targetome Revealed Its Mechanistic Role in the Maintenance of Liver Homeostasis and Suppressing Hepatocarcnogenesis
Department of Pathology, The Ohio State University, USA

Session 5: ncRNA Technologies 

Prof. Thomas Schmittgen - MicroRNAs Shape Plasticity of Pancreatic Acini
College of Pharmacy, University of Florida, Gainesville, USA

Prof. Jo Vandesompele - Tools for lncRNA Research in Cancer 
Chair of the Cancer Research Institute, Ghent University, Belgium

Prof. Maite Huarte Martinez - Functional long Non-Coding RNAs in Cancer Pathways
Center for Applied Medical Research (CIMA), University of Navarra, Spain 

Sponsors