State-of-the-Art Webinars on COVID-19 Research
Living with COVID-19: An Early Intervention Therapeutic Strategy to Control the Pandemic
Webinar Secretariat: firstname.lastname@example.org
The following expert researcher will present and speak:
Dr. Hamid Merchant
Dr Merchant has a Pharmacy degree (BPharm) with a Masters in Pharmaceutics (MPharm) from University of Karachi and a PhD in Pharmaceutical Formulations from the University College London (UCL). He also have a PGD in Quality Management from NED and a PGCert in Higher Education from Huddersfield.
Dr Merchant has a particular interest in drug delivery research at the interface of gastroenterology and publishes in various aspects of oral delivery.
On Wednesday 24 June 2020, MDPI and Sciforum organised the seventh webinar in the COVID-19 series. The State-of-the-Art Webinars on COVID-19 are a series of webinars discussing the current state of research in the context of the corona crisis and also focus on the acute and long-term influence of the current situation.
In his presentation entitled “Living with COVID-19: An Early Intervention Therapeutic Strategy to Control the Pandemic”, Dr. Hamid Merchant discussed the different therapeutic strategies that can be adopted in the early stages of the infection.
The webinar was offered via Zoom and required registration in order to attend, however, the full recording can be found below.
The next edition of the State-of-the-Art Webinars on COVID-19 will be held on Tuesday 30 June 2020 at 3:00pm (CEST). The title of the webinar is “Impact of COVID-19 on Routine Immunization, Reproduction and Pregnancy Outcome”. The guest speakers will be Prof. Dr. Jon Øyvind Odland, talking of pregnancy and COVID-10, and Prof. Dr. Prof. Dr. Giovanni Gabutti, speaking of the impact of COVID-19 on Routine Immunizations. You can register here.
Unanswered Questions during Q&A session
- Chlorhexidine causes brown staining for teeth surface and needs scaling to remove. From Samir Haj Bloukh
Yes, this is a common side effect but product is still widely used and a popular choice in dental practices across UK. If you are using this in CoViD-19 setting, staining can be potentially prevented by brushing/cleaning the teeth after rinsing mouth/throat with chlorhexidine solution. There can be alternatives to chlorhexidine, such as antiseptics mouth rinses containing povidone iodine solution.
- Political role of WHO, CDC FDA is also questionable nowadays, pls comment. From Saima Mahmood Malhi
It is true that the statements in the press and politicians have played a significant role in public understanding and perception of CoViD-19, particularly misinformation over the social media and misinterpretation of scientific studies by the press has been a major concern.
- Is acetyl cysteine is useful in this condition? From Aisha Sana
Acetylcysteine is the N-acetyl derivative of the amino acid L-cysteine and is considered effective to help with liver toxicity following paracetamol overdose or fatty-liver disease. It also helps loosen the thick mucus in patients with cystic fibrosis or COPD. Refer https://doi.org/10.1038/s41598-018-26033-z and https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270338/ on hepatotoxicity/liver function. There is a hypothesis that it may also prevent COVID-19-associated cytokine storm and the acute respiratory distress syndrome observed in severe ill CoViD19 patients, please refer https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195028/ There are some ongoing clinical trials to confirm its effectiveness in CoViD19 that should provide a conclusive answer soon, for instance this one, https://clinicaltrials.gov/ct2/show/NCT04374461
- Is there any evidence of essential oils inhibiting cytokine storm? From Naseem Akhter
Some components of essential oils have been reported to possess anti-inflammatory properties, however, evidence is not very strong to suggest that they would be able to prevent cytokine release syndrome. However, their antiviral/antimicrobial properties along with heat attenuation from steam can help reducing the viral load in nasal and oropharyngeal region in combination with an antiseptic mouth/throat rinse and lozenges. The throat rinse with anti-inflammatory drugs such as aspirin or benzydamine solution can help with the inflammation and potentially prevent the development of a more severe inflammatory disorder.
- What do you think about Hydroxychloroquine? From Adil Hakeem Khan
The evidence is still not very strong and there are issues concerning the safety and toxicity if permitted for mass use by the public. Due to lack of evidence around CQ/HCQ in preventing the CoViD-19, its potential risk of fatal cardiac arrhythmia, and greater risk of self-use and harm in the developing world, it is recommended that the use of CQ/HCQ should only be initiated by specialist clinician dealing with CoViD-19 outbreak to treat CoViD-19 associated pneumonia under close cardiac monitoring, unless proven otherwise by an RCT. Please refer https://doi.org/10.5920/bjpharm.745 for further details.
- What is your comment on COVID19 shifting from respiratory to vasculotropic disease? From Naseem Akhter
Yes, it has been a cause of concern and coagulopathy has been one of the main reason for CoViD-19 associated mortality. Clinicians in UK have suggested to use low dose aspirin as soon as patients get CoViD-19 to prevent any severe form of coagulation disorder, please refer: https://www.bmj.com/content/369/bmj.m2035/rr-1 for details. It may be that a throat rinse with aspirin or benzydamine solution could proivde a more targetted localised effect in the throat in the early disease, please refer: https://www.bmj.com/content/369/bmj.m2035/rr-2
- What do you think about immune based vaccine? From Adil Hakeem Khan
Vaccines are a type of immunotherapy – not sure if I have understood your question.
- May I ask your opinion about the heparin use? From Ferdinando Mannello
Heparin has been in-use across hospitals to prevent thrombus formation in severely ill hospitalised patients with CoViD-19 as this has been one of the main reasons for CoViD-19 associated mortality. However, if a low dose aspirin is started as an early intervention in CoViD-19 patients, we could potentially prevent a coagulation disorder. please refer: https://www.bmj.com/content/369/bmj.m2035/rr-1 and https://www.bmj.com/content/369/bmj.m2035/rr-2 for further details.
COVID-19 Academic Resources Center
To support health researchers and professionals during the COVID-19 pandemic, MDPI has established the COVID-19 Academic Resources Center. It contains a variety of information related to COVID-19 available from MDPI, including journal articles, special issues, and Preprints, among others.
Relevant Special Issues in MDPI Journals
Special Issues in International Journal of Environmental Research and Public Health
Risk Management of COVID-19 and Public Health: Medical, Economic, Finance, Business, Political and Educational Implications
Editors: Michael McAleer, Chia-Lin Chang, Daniel J. Slottje, Teodosio Pérez Amaral
Accepting submissions until 30 April 2021
Old and New Epidemiological Alerts: Prevention and Control of COVID-19, Candida auris, Measels, MDR and Other Infectious Diseases
Editors: Jadwiga Wojkowska-Mach, Maria Luisa Moro, Monika Chlebowicz, Anna Różańska
Accepting submissions until 28 February 2021
COVID-19 Global threat: Information or Panic
Editors: Carlos de las Heras-Pedrosa, Carmen Jambrino-Maldonado, Patricia P. Iglesias-Sánchez, Jose Ignacio Peláez-Sánchez
Accepting submissions until 20 December 2020
SARS-CoV2 and COVID-19 Outbreak: Lessons, Burning Points and Perspectives
Editor: Evelyne Bischof
Accepting submissions until 31 October 2020
COVID-19 in Pharmaceuticals
Editors: Jean Jacques Vanden Eynde, Annie Mayence
Accepting submissions until 15 November 2020
Articles in COVID-19 in Pharmaceuticals
COVID-19: An update about the Discovery Clinical Trial
Editor: Jean Jacques Vanden Eynde
COVID-19: A Brief Overview of the Discovery Clinical Trial
Editor: Jean Jacques Vanden Eynde
COVID-19: Defense Strategies and Technologies
Editor: Silvano Vergura
Accepting submissions until 31 August 2021
Circular Economy in the COVID-19 Era
Editors: Jouni Korhonen and Juha-Pekka Snäkin
Accepting submissions until 15 December 2020
ICMTs for Sustainability in the Post COVID-19 Era: Revisiting Conceptual and Policy Narratives
Editors: Ravi S. Sharma, Stephen Bekoe and Aijaz A. Shaikh
Accepting submissions until 31 October 2020
Working during the COVID-19 Global Pandemic
Editors: Emanuele Cannizzaro, Ramaci Tiziana, Massimiliano Barattucci and Fulvio Plescia
Accepting submissions until 15 April 2021
Sustainability vs Uncontrollability: COVID-19 and Crisis Impact on the Hospitality and Tourism Community
Editors: Myong Jae Lee and Saehya Ann
Accepting submissions until 31 January 2021
Pilgrimage and Sustainability in the Post COVID 19 Era
Editor: Noga Collins-Kreiner
Accepting submissions until 10 June 2021