Cancers Webinar | Kinases in Cancer and Other Diseases
the chair
5th Cancers Webinar
Kinases in Cancer and Other Diseases
Protein kinases are a big family of enzymes, which catalyze protein phosphorylation. The human genome contains 518 protein kinase genes. Phosphorylation is one of the major mechanisms for regulating various cellular processes, such as proliferation, apoptosis cell cycle, growth, apoptosis, differentiation, etc. Deregulation of kinase activity can result in striking changes in these processes. Furthermore, deregulated kinases are often found to be oncogenic and can be important for the survival and spreading of cancer cells. There are different ways for kinases to become involved in cancers: mis-regulated expression and/or amplification, mutation, chromosomal translocation, abnormal phosphorylation, and epigenetic regulation. Based on these assumptions there are a lot of variuos scientific projects assessing the importance of kinases in cancers as well as some other diseases, such as polycystic kidney disease, glomerulonephritis, neurodegeneration, retinal degeneration, lung inflammation and others. In clinical science the major two kinase investigation routes are using kinases as biomarkers in cancer prognostics and diagnostics as well treating cancers with kinase inhibitors and/or monoclonal antibodies. This webinar will provide us with some highlights on the new research achievements in those areas.
Date: 17 March 2022
Time: 4:00pm CET | 11:00am EDT | 11:00pm CST Asia
Webinar ID: 891 1874 7120
Webinar Secretariat: cancers.webinar@mdpi.com
Meet Our Speakers
Dr. Jonas Cicenas
Proteomics Centre, Institute of Biochemistry, Vilnius University Life Sciences Centre, Lithuania, MAP Kinase Resource, Bioinformatics, Bern, Switzerland;
2004 PhD in biochemistry, University of Basel, Switzerland
2011-2015 worked at Swiss Institute of Bioinformatics, CALIPHO group as biocurator-kinase expert
2017-2018 worked at Max F. Perutz Laboratories - University of Vienna
Department of Microbiology, Immunology and Genetics as data scientist
since 2018 works Proteomics Centre, Institute of Biochemistry, Vilnius University Life Sciences Centre as senior scientist and Vilnius Gediminas Technical University, Department of Chemistry and Bioengineering as asisstant professor
ORCID: https://orcid.org/0000-0002-9365-1843
Sponsors and Partners
Organizer
On Thursday, 17 March 2022, MDPI and the Journal Cancers organized the 6th webinar on Cancers, entitled "Kinases in Cancer and Other Diseases".
The introduction was held by the Chair of the webinar, Dr. Jonas Cicenas from the Institute of Biochemistry at the Vilnius University Life Sciences Centre in Lithuania. His research interests are focused on cell signaling (protein kinases in particular) and its role both in normal cells as well as in diseases, such as breast, prostate cancer and leukemia. Dr. Cicenas is also a founder of MAP Kinase Resource, an online knowledge platform and database dedicated to mitogen-activated protein kinases.
The first speaker to kick off this webinar was Dr. Lee M. Graves. His lab, the Graves Lab, at the University of North Carolina, Chappel Hill School of Medicine, Derpartment of Pharmacology in the United States is investigating cellular mechanisms of drug resistance in cancer. Dr. Graves has over 20 years experience studying protein kinases and protein phosphorylation. His presentation was entitled "Affinity Profiling to Discover New Targets for Cancer Treatments".
The second presentation with the title "Fluorescent Peptide Biosensors for Probing Kinase Activities: Tools for Profiling Biomarker Signatures in Cancer Diagnostics" was held by Dr. May C. Morris. In 2014 Dr. Morris moved to the Institute of Biomolecules Max Mousseron, where she is currently in charge of the "Cell Cycle Biosensors and Inhibitors" group within the Department of Amino Acids, Heterocycles, Peptides and Proteins for Health.
The presentations were followed by a Q&A and a discussion, moderated by the Chair. The webinar was offered via Zoom and required registration to attend. The full recording can be found here on Sciforum website. In order to stay updated on the next webinars on Cancers, be sure to sign up for our newsletter by clicking on “Subscribe” at the top of the page.
Topical Collection "Kinases and Cancer"
Collection Editor: Dr. Jonas Cicenas
Kinases in Cancer and Other Diseases
Topic Editors: Dr. Jonas Cicenas & Dr. May C. Morris
Deadline for abstract submissions: 30 November 2022
Deadline for manuscript submissions: 28 February 2023