Cells Webinar | Mechanism of Cell Signaling during Eye Development and Diseases
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25st Webinar on Cells
Mechanism of Cell Signaling during Eye Development and Diseases
We cordially invite you to take part in the Webinar devoted to the Special Issue ‘Mechanism of Cell Signaling during Eye Development and Diseases’. Cell signaling pathways are important in mediating essential processes in embryonic eye development and adult tissues. Their coordination and integration are critical for mediating processes ranging from cell proliferation and differentiation to cell fate determination and polarity. Cellular communication is compelled by these pathways and is driven by hormones, transcription factors, or other signaling molecules.
Several major signaling pathways in eye development such as Hedgehog, Wnt, retinoic acid, FGF, TGF-β, and Notch operate during development, in a precise temporal and spatial patterning in the embryo and in adult tissues, generating diverse cellular responses in a cell-type-specific manner. Altered expressions of these pathways can lead to a large number of eye diseases, such as photoreceptor degeneration, Glaucoma, pathological angiogenesis-related eye disorders, and diseases such diabetic retinopathy and keratopathy
Therefore, delineating the mechanisms of cell signaling during eye development and disease can unveil their potential as targets for novel therapeutic strategies for the treatment of ocular diseases.
The same subjects will be presented in this Webinar, which will involve the molecular mechanisms of stem cell maintenance, proliferation and differentiation in homeostasis and disease state of eye.
Date: 24 April 2024
Time: 7:00 pm CEST | 10:00 am PDT | 1:00 pm EDT
Webinar ID: 845 3170 9651
Webinar Secretariat: journal.webinar@mdpi.com
Meet Our Chair
Associate Professor of Biomedical Sciences & Regenerative Medicine Institute Cedars-Sinai Medical Center;Associate Professor of Medicine, UCLA School of Medicine;Dr. Mehrnoosh Saghizadeh Ghiam is Associte professor of Biomedical Sciences and Regenrative Medicine Institute at Cedars-Siani Medical Center and Adjunct Associate Professor of Medicine at UCLA School of Medicine. She received her Ph.D. degrees from UCLA and completed her postdoctoral training in the Department of Surgery at Cedars-Sinai Medical center, where she joined faculty position as Assistant Professor in 2012. The main focus of her research is to identify specific molecular defects in diabetic corneas, with the goal of restoring stem cell function. Her lab is interested in defining the roles of microRNAs and extracellular vesicles in stem cell maintenance and activation in the limbal stem cell niche and their therapeutic potential for treatment of corneal injuries and diabetic abnormalities. Her research has been funded by NIH since 2012 as a principal investigator/co-investigator. she is an editorial board member and ad-hoc reviewer of several scientific journals and member of several international vision research societies. She has been serving on numerous NIH Study Sections and has been a grant reviewer for various agencies in U.S., U.K., Poland and Ireland.
Meet Our Speakers
VA Medical Center, United States;
UAB Department of Ophthalmology and Visual Sciences, Birmingham, United States;Dr. Maria Grant, M.D., FARVO, is the Eivor and Alston Callahan Endowed Chair and Professor of Department of Ophthalmology and Visual Science. Dr. Grant’s laboratory is interested in understanding the role of hematopoietic cells and vascular wall derived progenitor cells in vascular repair in aging and diabetes. Dr. Grant’s research focuses on understanding the biology of hematopoietic progenitor cell emergence, maintenance, and their regenerative properties. More recently she has examined the role of the renin angiotensin system in the intestine and how that impacts glucose homeostasis and immune function in aging and diabetes. She has served as principle/co-investigator on more than forty extramural foundation/NIH grants that have led to more than 270 peer reviewed publications.
Professor of Biomedical Sciences and Neurosurgery;Director, Regenerative Medicine Institute Eye Program;Cedars-Sinai Medical Center;Professor of Medicine, UCLA School of Medicine;Dr. Alexander Ljubimov is an internationally recognized eye and cancer researcher, with over 130 peer-reviewed papers, reviews, and book chapters published. He is Director of Regenerative Institute Eye Program at Cedars-Sinai Medical Center, Professor of Biomedical Sciences and Neurosurgery, and Adjunct Professor of Medicine at the David Geffen School of Medicine at UCLA. His research includes innovative gene and epigenetic therapy to restore normal stem cell functions in diabetic corneas, development of new targeted nanotherapeutics for cancer and eye diseases and making corneal cells from induced pluripotent stem cells. Dr. Ljubimov's research has been funded by NIH since 1995 with 3 current R01 grants. He has been serving on numerous NIH Study Sections, and has been a grant reviewer for various agencies in U.S., U.K., France, Italy, Switzerland, Belgium, Australia, and the Netherlands. Dr. Ljubimov is an Editorial Board member of 16 scientific journals including Stem Cells Translational Medicine, Investigative Ophthalmology and Visual Science, Progress in Retinal and Eye Research, Experimental Eye Research, Molecular Vision, Experimental Biology and Medicine, PLoS One, Cells, Scientific Reports, and Ocular Surface. He is Gold Fellow of the Association for Research in Vision and Ophthalmology (ARVO) and Overseas Fellow of the Royal Society of Medicine (U.K.). Dr. Ljubimov received his summa cum laude M.S. degree from Moscow State University (Russia), and his Ph.D. and D.Sc. degrees from the Russian Cancer Research Center. He completed postdoctoral training in the International Agency for Research on Cancer in Lyon (France). He has a background in cancer research and is working on diabetic eye disease since 1993.
In this section, you will find the recordings of this webinar to watch, re-watch and share with your colleagues!
Mechanism of Cell Signaling during Eye Development and Diseases
Edited by Dr. Mehrnoosh Saghizadeh Ghiam and Dr. Vivien Coulson-Thomas