Please login first

Cells Webinar | Mechanism of Cell Signaling during Eye Development and Diseases

24 Apr 2024, 19:00 (CEST)

Eye Development, Eye Diseases, Cornea, Cell Signaling, Stem Cells, Diabetes, Wound Healing, Gene Therapy, Retina Ocular Surface
Bookmark event Remove event from bookmarks
Add this event to bookmarks
Event Registration Contact Us

Welcome from the Chair

25st Webinar on Cells

Mechanism of Cell Signaling during Eye Development and Diseases

We cordially invite you to take part in the Webinar devoted to the Special Issue ‘Mechanism of Cell Signaling during Eye Development and Diseases’. Cell signaling pathways are important in mediating essential processes in embryonic eye development and adult tissues. Their coordination and integration are critical for mediating processes ranging from cell proliferation and differentiation to cell fate determination and polarity. Cellular communication is compelled by these pathways and is driven by hormones, transcription factors, or other signaling molecules.

Several major signaling pathways in eye development such as Hedgehog, Wnt, retinoic acid, FGF, TGF-β, and Notch operate during development, in a precise temporal and spatial patterning in the embryo and in adult tissues, generating diverse cellular responses in a cell-type-specific manner. Altered expressions of these pathways can lead to a large number of eye diseases, such as photoreceptor degeneration, Glaucoma, pathological angiogenesis-related eye disorders, and diseases such diabetic retinopathy and keratopathy

Therefore, delineating the mechanisms of cell signaling during eye development and disease can unveil their potential as targets for novel therapeutic strategies for the treatment of ocular diseases.

The same subjects will be presented in this Webinar, which will involve the molecular mechanisms of stem cell maintenance, proliferation and differentiation in homeostasis and disease state of eye.

Date: 24 April 2024

Time: 7:00 pm CEST | 10:00 am PDT | 1:00 pm EDT

Webinar ID: 845 3170 9651

Webinar Secretariat:

Webinar Recording (Registered Only)

In this section, you will find the recordings of this webinar to watch, re-watch and share with your colleagues!


This is a FREE webinar. After registering, you will receive a confirmation email containing information on how to join the webinar. Registrations with academic institutional email addresses will be prioritized.

Certificates of attendance will be delivered to those who attend the live webinar.

Can’t attend? Register anyway and we’ll let you know when the recording is available to watch.

Event Chair

Associate Professor of Biomedical Sciences & Regenerative Medicine Institute Cedars-Sinai Medical Center,
Associate Professor of Medicine, UCLA School of Medicine

Dr. Mehrnoosh Saghizadeh Ghiam is Associte professor of Biomedical Sciences and Regenrative Medicine Institute at Cedars-Siani Medical Center and Adjunct Associate Professor of Medicine at UCLA School of Medicine. She received her Ph.D. degrees from UCLA and completed her postdoctoral training in the Department of Surgery at Cedars-Sinai Medical center, where she joined faculty position as Assistant Professor in 2012. The main focus of her research is to identify specific molecular defects in diabetic corneas, with the goal of restoring stem cell function. Her lab is interested in defining the roles of microRNAs and extracellular vesicles in stem cell maintenance and activation in the limbal stem cell niche and their therapeutic potential for treatment of corneal injuries and diabetic abnormalities. Her research has been funded by NIH since 2012 as a principal investigator/co-investigator. she is an editorial board member and ad-hoc reviewer of several scientific journals and member of several international vision research societies. She has been serving on numerous NIH Study Sections and has been a grant reviewer for various agencies in U.S., U.K., Poland and Ireland.

Invited Speakers

VA Medical Center, United States

Dr. Rajiv Mohan is a Curators’ Distinguished Professor and Ruth M Kraeuchi Endowed Chair of Ophthalmology and Molecular Medicine at the University of Missouri, Columbia, Missouri, USA. Additionally, he holds a Senior Research Career Scientist position at the US Department of Veterans Affair’s Harry S. Truman Medical Center Columbia, Missouri. Dr. Mohan’s lab is focused on studying mechanisms causing corneal blindness and developing novel gene therapies and ophthalmic formulations to prevent and treat vision loss in humans and companion/service animals using state-of-the-art multimodal 2D/3D in vivo eye imaging, molecular techniques, preclinical in vivo animals (rodent, rabbit, and pig) and human in vitro and ex vivo organ culture models. Dr. Mohan’s research program is funded through multiple NIH, VA, and foundation grants. He has coauthored >180 peer-reviewed journal articles, 12 book chapters, and >400 meeting abstracts as well as received many prestigious national/international awards. Dr. Mohan routinely serves in various grant review panels as a member, chair or co-chair of the USA, Europe, and Asia, in Editorial Board of 10 journals, and international vision research societies (ARVO, ISER, WOC etc.) at different capacities. He has co-organized many national and international eye research meetings/conferences, chaired/co-chaired scientific sessions, and delivered >120 invited lectures in 30+ countries. In 2023, for the second consecutive year, Dr. Mohan was named among “World’s Top 2% of Scientists” by the Elsevier science-wide author databases of standardized citation indicators.

UAB Department of Ophthalmology and Visual Sciences, Birmingham, United States

Dr. Maria Grant, M.D., FARVO, is the Eivor and Alston Callahan Endowed Chair and Professor of Department of Ophthalmology and Visual Science. Dr. Grant’s laboratory is interested in understanding the role of hematopoietic cells and vascular wall derived progenitor cells in vascular repair in aging and diabetes. Dr. Grant’s research focuses on understanding the biology of hematopoietic progenitor cell emergence, maintenance, and their regenerative properties. More recently she has examined the role of the renin angiotensin system in the intestine and how that impacts glucose homeostasis and immune function in aging and diabetes. She has served as principle/co-investigator on more than forty extramural foundation/NIH grants that have led to more than 270 peer reviewed publications.

Professor of Biomedical Sciences and Neurosurgery,
Director, Regenerative Medicine Institute Eye Program,
Cedars-Sinai Medical Center,
Professor of Medicine, UCLA School of Medicine

Dr. Alexander Ljubimov is an internationally recognized eye and cancer researcher, with over 130 peer-reviewed papers, reviews, and book chapters published. He is Director of Regenerative Institute Eye Program at Cedars-Sinai Medical Center, Professor of Biomedical Sciences and Neurosurgery, and Adjunct Professor of Medicine at the David Geffen School of Medicine at UCLA. His research includes innovative gene and epigenetic therapy to restore normal stem cell functions in diabetic corneas, development of new targeted nanotherapeutics for cancer and eye diseases and making corneal cells from induced pluripotent stem cells. Dr. Ljubimov's research has been funded by NIH since 1995 with 3 current R01 grants. He has been serving on numerous NIH Study Sections, and has been a grant reviewer for various agencies in U.S., U.K., France, Italy, Switzerland, Belgium, Australia, and the Netherlands. Dr. Ljubimov is an Editorial Board member of 16 scientific journals including Stem Cells Translational Medicine, Investigative Ophthalmology and Visual Science, Progress in Retinal and Eye Research, Experimental Eye Research, Molecular Vision, Experimental Biology and Medicine, PLoS One, Cells, Scientific Reports, and Ocular Surface. He is Gold Fellow of the Association for Research in Vision and Ophthalmology (ARVO) and Overseas Fellow of the Royal Society of Medicine (U.K.). Dr. Ljubimov received his summa cum laude M.S. degree from Moscow State University (Russia), and his Ph.D. and D.Sc. degrees from the Russian Cancer Research Center. He completed postdoctoral training in the International Agency for Research on Cancer in Lyon (France). He has a background in cancer research and is working on diabetic eye disease since 1993.



Time in PDT

Time in CEST

Dr. Mehrnoosh Ghiam

Chair Introduction

10:00 - 10:10 am

7:00 - 7:10 pm

Prof. Dr. Rajiv Mohan

Targeted Gene Therapy for Corneal Blindness Treatment

10:10 - 10:30 am

7:10 - 7:30 pm

Prof. Dr. Maria Grant

The Role of the Gut-Retinal Axis in Development of Diabetic Retinopathy

10:30 - 10:50 am

7:30 - 7:50 pm

Prof. Dr. Alexander Ljubimov

Epigenetic Dysregulation of Non-canonical Wnt Signaling in the Diabetic Cornea

10:50 - 11:10 am

7:50 - 8:10 pm

Q&A Session

11:10 - 11:25 am

8:10 - 8:25 pm

Closing of Webinar
Dr. Mehrnoosh Ghiam

11:25 - 11:30 am

8:25 - 8:30 pm

Relevant Special Issue

Mechanism of Cell Signaling during Eye Development and Diseases

Edited by Dr. Mehrnoosh Saghizadeh Ghiam and Dr. Vivien Coulson-Thomas

Deadline for manuscript submissions: 30 June 2024

Sponsors and Partners