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Cells Webinar | The Interaction of Biomedical Nanoparticles with the Immune System

25 Jun 2021, 10:00

Cells, Nanoparticles, Immune System, Inflammation, Risk Assessment
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Welcome from the Chair

9th Webinar on Cells

The Interaction of Biomedical Nanoparticles with the Immune System

The use of nanoparticles in different biomedical applications, such as targeted drug delivery, hyperthermia, photoablation therapy, bioimaging and biosensors, exhibits several advantages compared to conventional therapeutics of many diseases, and significantly overcomes the current therapeutic limitations. Despite multiple nanoparticles have already reached the clinic, the translation is often hampered due to their potential toxic effects, including immunological alterations. Our immune system has a crucial role in protecting us from foreign intruders, and sometimes nanoparticles are recognized as intruders. In this regard, many strategies have been attempted to improve the therapeutic efficacy of nanoparticles and exploit their unique properties for the treatment of immune related diseases.

This webinar will certaintly help to give new insigths about the “The interaction of biomedical nanoparticles with the immune system” through the presentation of three representative works under this theme. The Special Issue under this same theme, which will be published by the open access journal Cells, is open for submissions.

Date: 25 June 2021

Time: 10:00 am CEST | 4:00 am EDT | 4:00 pm CST Asia

Webinar ID: 883 4927 2541

Webinar Secretariat: cells.webinar@mdpi.com

Chair

LAQV, REQUIMTE, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal

DETAILS
Bio
Marisa Freitas (MF) completed her PhD degree in Pharmaceutical Sciences in 2010, in the Faculty of Pharmacy of University of Porto. Currently, she is Assistant Researcher at LAQV-REQUIMTE - Associate Laboratory for Green Chemistry, working at the Laboratory of Applied Chemistry of FFUP. Her scientific background is supported by 78 publications in international journals, 5 book chapters, 40 oral communications and 100+ poster communications in national and international conferences, with 3 attributed awards. Her h-index is 29, with 2500+ citations (Scopus). MF participated in several projects funded by national and international funds. She collaborates as reviewer in 20+ journals (Publons - Web of Science Researcher ID AAY-7427-2020) and participates in the Editorial Board of 4 journals (Molecules, Cells, Oxid Med Cell Longev, Braz J Pharm Sci).

Invited Speakers

LAQV, REQUIMTE, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal

DETAILS
Bio
Ana T. Rufino received her PhD degree in 2015 in Pharmacy at the Coimbra University (Coimbra, Portugal) in the field of Pharmacology and Pharmacotherapy of natural products and inflammation. Her research interests are the identification of natural products for therapeutic use as well as further validation and exploration of their potential use in different pathologies with a chronic inflammatory component. Currently, she is a researcher in an internationally recognized research Centre in the area of Green Chemistry, LAQVREQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.

Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy

DETAILS
Bio
Luisa Fiandra is Researcher and Assistant Professor in Clinical Biochemistry at the Department of Biotechnology and Biosciences of University of Milano Bicocca, and she is also member of Centro 3R (Inter-University Center for the Promotion of the 3Rs Principles in Teaching & Research. Up to 2017, LF coordinated pre-clinical studies mainly devoted to the use of nanotechnology for cancer therapy and diagnosis, and for biological barriers overcoming. From 2018, LF participate to EU projects aimed to determine the toxicity of different types of nanoproducts by in vitro assays and on alternative vertebrate models (Zebrafish), in line with the Safe-by-Design concept for the development of new nanoformulated nanotools. Currently, LF is devoted to the use of advanced cellular models for the validation of conventional or latest generation therapies directed towards tumor pathologies. The research activity is now mainly focused on the study of the tumor-associated immune system activation and ADCC, and on innovative strategies involving tumor microenvironment cells reprogrammed by genetic approaches to eradicate desmoplastic tumors.

Istituto di Biochimica e Biologia Cellulare, Consiglio Nazionale delle Ricerche, Napoli, Italy

DETAILS
Bio
Paola Italiani has a Specialisation degree in Clinical Biochemistry and a PhD in Molecular Medicine. [...] In particular, she has studied the effects of novel adjuvants derived from plant polysaccharides on human macrophages, fibroblasts, and epithelial cells, with special emphasis on the role of the IL-1R/TLR family and their cytokine ligands IL-1 and IL-18. In the last years, she has focussed her research interest on the mechanisms of the inflammatory response and of the activation of innate defense cells in physiological conditions and during pathological derangements. In this context, she is studying the role of human monocytes and macrophages in the development of the inflammatory response, in terms of their functional polarization in response to different microenvironments, and their consequent capacity to differentially shaping the inflammatory reaction. She has designed and implemented a human primary cell-based in vitro model of innate immune/inflammatory response. In human diseases, she is focusing on the cross-regulation of factors and receptors of the IL-1/IL18 family in chronic inflammatory, autoimmune and degenerative pathologies (e.g., ALS, SLE, Alzheimer disease). Moreover, she is studying the modulation of monocyte/macrophage functions for predictive assessment of the health hazard posed by engineered nanoparticles and nanomedicines (immuno-nanosafety). Recently, she is approaching the study of the mechanisms involved in memory of the innate immune cells.

Webinar Content

On Friday, 25 June 2021, MDPI and the Journal Cells organized the 9th webinar on Cells, entitled "The Interaction of Biomedical Nanoparticles with the Immune System".

The introduction was held by the Chair of the webinar, Dr. Marisa Freitas, an Assistant Researcher at the Associated Laboratory for Green Chemistry of the Network of Chemistry and Technology, working at the Laboratory of Applied Chemistry of the Faculty of Pharmacy at the University of Porto (LAQV-REQUIMTE). Her scientific background is supported by 78 publications in international journals, 5 book chapters, 40 oral communications and over 100 poster communications in national and international conferences, with 3 attributed awards. She participated in several projects funded by national and international funds and she collaborates as a reviewer in more than 20 journals and participates in the Editorial Board of 4 journals.

The first speaker to quick off this webinar was Dr. Ana Rufino. She is also a researcher in the internationally recognized research centre in the area of Green Chemistry, LAQV-REQUIMTE in Porto, Portugal. Her research interests are the identification of natural products for therapeutic use as well as further validation and exploration of their potential use in different pathologies with a chronic inflammatory component. Her presentation was entitled "Protective Role of Flavonoids Against Intestinal Pro-Inflammatory Effects of Silver Nanoparticles".

The second presentation with the title "H-Ferritin Nanoparticles for the Activation of ADCC Response: A Promising Strategy for Cancer Therapy" was held by Dr. Luisa Fiandra. She is an Assistant Professor in Clinical Biochemistry at the Department of Biotechnology and Biosciences of the University of Milano-Bicocca in Italy, and she is also a member of Centro 3R (Inter-University Center for the Promotion of the 3Rs Principles in Teaching & Research). She is devoted to the use of advanced cellular models for the validation of conventional or latest generation therapies directed towards tumor pathologies.

Dr. Paola Italiani from the Institute of Protein Biochemistry at the National Research Council in Naples, Italy was the third speaker and her presentation was entitled "Modulation of Innate Immune Memory: A New Perspective in the Personalized Biomedical Application of Nanoparticles". In the last years, she has focussed her research interest on the mechanisms of the inflammatory response and of the activation of innate defense cells in physiological conditions and during pathological derangements. In this context, she is studying the role of human monocytes and macrophages in the development of the inflammatory response, in terms of their functional polarization in response to different microenvironments, and their consequent capacity to differentially shaping the inflammatory reaction.

Each presentation was followed by a short Q&A, moderated by the Chair. The webinar was offered via Zoom and required registration to attend. The full recording can be found here on Sciforum website. In order to stay updated on the next webinars on Cells, be sure to sign up for our newsletter by clicking on “Subscribe” at the top of the page.

Program

Speaker/Presentation

Time in CEST

Dr. Marisa Freitas

Chair Introduction

10:00 - 10:05 am

Dr. Ana Rufino

Protective Role of Flavonoids Against Intestinal Pro-Inflammatory Effects of Silver Nanoparticles

10:05 - 10:25 am

Q&A

10:25 - 10:30 am

Dr. Luisa Fiandra

H-Ferritin Nanoparticles for the Activation of ADCC Response: A Promising Strategy for Cancer Therapy

10:30 - 10:50 am

Q&A

10:50 - 10:55 am

Dr. Paola Italiani

Modulation of Innate Immune Memory: A New Perspective in the Personalized Biomedical Application of Nanoparticles

10:55 - 11:20 am

Q&A

11:20 - 11:25 am

Closing of Webinar
Dr. Marisa Freitas

11:25 - 11:30 am

Relevant SIs

The Interaction of Biomedical Nanoparticles with the Immune System
Guest Editors: Dr. Marisa Freitas, Prof. Dr. Francesca Granucci, Dr. Daniela Ribeiro
Deadline for manuscript submissions: 31 August 2021

Frontiers in Oncology Nanomedicine: Toward Novel Personalized Medicine Tools to Fight Human Cancer
Guest Editor: Dr. Sergio Comincini
Deadline for manuscript submissions: closed (30 April 2021)

Sponsors and Partners

Organizers

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