Genes 2023 - Single-Cell Genomics Moving Forward

Head, Division Computational Genomics and Systems Genetics, German Cancer Research Center (DKFZ), Germany;

Department of Statistics, Division of Biostatistics, School of Public Health University of California, Berkeley, USA;
Sandrine Dudoit is Professor and Chair of the Department of Statistics and Professor in the Division of Biostatistics, School of Public, at the University of California, Berkeley. Professor Dudoit's methodological research interests regard high-dimensional inference and include exploratory data analysis (EDA), visualization, loss-based estimation with cross-validation (e.g., density estimation, classification, regression, model selection), and multiple hypothesis testing. Much of her methodological work is motivated by statistical inference questions arising in biological research and, in particular, the design and analysis of high-throughput microarray and sequencing gene expression experiments, e.g., single-cell transcriptome sequencing (RNA-Seq) for discovering novel cell types and for the study of stem cell differentiation. She is a founding core developer of the Bioconductor Project (http://www.bioconductor.org), an open-source and open-development software project for the analysis of biomedical and genomic data. Professor Dudoit is a co-author of the book Multiple Testing Procedures with Applications to Genomics (2008) and a co-editor of the book Bioinformatics and Computational Biology Solutions Using R and Bioconductor (2005). She was named Fellow of the American Statistical Association in 2010, Elected Member of the International Statistical Institute in 2014, and Fellow of the Institute of Mathematical Statistics in 2021. Professor Dudoit obtained a Bachelor's degree (1992) and a Master's degree (1994) in Mathematics from Carleton University, Ottawa, Canada. She first came to UC Berkeley as a graduate student and earned a PhD degree in 1999 from the Department of Statistic. She was a postdoctoral fellow at the Mathematical Sciences Research Institute (MSRI), Berkeley and in the laboratory of Professor Patrick O. Brown, Department of Biochemistry, Stanford University (1999–2001).

Josep Carreras Leukemia Research Institute, Badalona, Barcelona, Spain;
Manel Esteller (Sant Boi de Llobregat, Barcelona, Catalonia, Spain, 1968) graduated in Medicine from the Universidad de Barcelona in 1992, where he also obtained his Ph.D. degree specialising in molecular genetics of endometrial carcinoma, in 1996. He was an Invited Researcher at the School of Biological and Medical Sciences at the University of St. Andrews, (Scotland, UK) during which time his research interests focused on the molecular genetics of inherited breast cancer. From 1997 to 2001, Esteller was a Postdoctoral Fellow and a Research Associate at the Johns Hopkins University and School of Medicine, (Baltimore, USA) where he studied DNA methylation and human cancer. His work was decisive in establishing promoter hypermethylation of tumour suppressor genes as a common hallmark of all human tumours. From October 2001 to September 2008 Manel Esteller was the Leader of the CNIO Cancer Epigenetics Laboratory, where his principal area of research were the alterations in DNA methylation, histone modifications and chromatin in human cancer. Since October 2008 until May 2019, Dr Esteller was the Director of the Cancer Epigenetics and Biology Program (PEBC) in Barcelona. He is the Director of the Josep Carreras Leukaemia Research Institute (IJC), Chairman of Genetics in the School of Medicine of the University of Barcelona, and an ICREA Research Professor. His current research is devoted to the establishment of the epigenome and epitranscriptome maps of normal and transformed cells, and the development of new epigenetic drugs for cancer therapy. Website: http://www.carrerasresearch.org/en