The 2nd International Electronic Conference on Antioxidants
7–9 Apr 2025
Oxidative Stress, Chronic Diseases, Health Promotion, Dietary Antioxidants, Antioxidant Enzymes, Antioxidant Extraction and Assay Methods, Food and Feed Uses, Cosmetic and Biomedical Applications
- Go to the Sessions
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- S1. Oxidative Stress in Obesity
- S2. Oxidative Stress and Inflammation in Cardiovascular Diseases
- S3. Antioxidants in Chronic Disease: From Dietary Prevention to Therapeutic Intervention
- S4. Antioxidants Intake and Gut Microbiome
- S5. Natural and Synthetic Antioxidants and Antioxidant Enzyme Systems
- S6. Antioxidants Extraction, Assay and Industrial Applications
- Event Details
Welcome from the Chair
Dear Colleagues,
You are cordially invited to participate in The 2nd International Electronic Conference on Antioxidants. This event will offer researchers working in the field of antioxidants the opportunity to present and discuss their latest research findings.
The conference is organized by the MDPI open-access journal Antioxidants and will be held as a three-day event on April 7–9, 2025.
At present, antioxidants encompass a significant area of investigation for researchers from many disciplines, and their importance in a variety of fields, from health and food to innovative materials, is increasingly appreciated.
Surveying the topics of the papers recently contributed to our journal, it appears that the fields covered are diverse and broad. We therefore chose to focus the conference theme on a few topics that are currently gaining considerable interest in order to allow for in-depth discussions among participants.
The implication of oxidative stress in severe pathological conditions at high incidence, such as cardiovascular diseases, or chronic conditions, such as obesity or diabetes, affecting large segments of the population is now largely documented; however, the underlying mechanisms of these diseases and conditions and possible interventions are yet to be defined.
The search for novel antioxidants, either natural or bioinspired, with high bioactivity represents a greatly pursued research goal, but it is the metabolism of these compounds and their effects on the gut microbiome that is perceived as a critical issue to address.
Methods for the efficient recovery of antioxidants from natural sources and possibly agri-food waste and by-products, their testing with robust and reproducible methodologies to allow for comparative evaluation and their use in nutrition, food preservation, biomedical and other applications are issues concentrating the efforts of investigators in the field.
In this edition of the e-conference, we have planned relatively short sessions and a lively discussion to take place after each presentation.
The topics selected for the six planned sessions are as follows:
S1: Oxidative Stress in Obesity
S2: Oxidative Stress and Inflammation in Cardiovascular Diseases
S3: Antioxidants in Chronic Disease: From Dietary Prevention to Therapeutic Intervention
S4: Antioxidants Intake and Gut Microbiome
S5: Natural and Synthetic Antioxidants and Antioxidant Enzyme Systems
S6: Antioxidant Extraction, Assay and Industrial Applications
Accepted abstracts will be published in the proceedings of the conference, and authors will be invited to submit their abstracts as full manuscripts, which will be considered for publication in a Special Issue of Antioxidants, with a 20% discount on the APC applied.
Conference Chair,
Prof. Dr. Alessandra Napolitano
University of Naples “Federico II”, Italy
Event Chair
Department of Chemical Sciences, University of Naples “Federico II”, Naples, Italy
Alessandra Napolitano has worked as a professor in Organic Chemistry in the department of Chemical Sciences of Naples University Federico II since 2011. She is the author or co-author of approximately 275 publications in peer reviewed journals (orcid.org/0000-0003-0507-5370, h-index: 55 march 2024) in the fields of Organic and Bioorganic Chemistry and has been an invited speaker and chairperson at several international conferences. Her teaching activities cover Organic Chemistry, Natural Product Chemistry and Food Chemistry She has also served as the doctorate coordinator for Chemical Sciences (38° cycle onward) and has been awarded with the Quilico Medal by the Italian Chemical Society, Organic Chemistry Division, and the Raper Medal by the International Federation of Pigment Cell Societies.
Session Chairs
Prof. Dr. Vicente Micol
Instituto de Investigación, Desarrollo e Innovación en Biotecnologia Sanitaria at Miguel Hernández University, Elche, Spain
Prof. Dr. Victoria Cachofeiro
Physiology Department, School of Medicine, Universidad Complutense, Madrid, Spain
Prof. Dr. Aldrin V. Gomes
1. Department of Neurobiology, Physiology, and Behavior, University of California, One Shields Ave., Davis, CA 95616, USA 2. Department of Physiology and Membrane Biology, University of California, Davis, CA 95616, USA
Prof. Dr. Jiankang Liu
1. School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China 2. School of Health and Life Sciences, University of Health and Rehabilitation Sciences, Qingdao, China
Dr. Raul Zamora-Ros
Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain
Prof. Dr. José Ángel Rufián-Henares
Departamento de Nutrición y Bromatología, Facultad de Farmacia, Universidad de Granada, Spain
Dr. Mario Allegra
Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche, Università degli Studi di Palermo, Palermo, Italy
Dr. Ren-You Gan
Department of Food Science and Nutrition, Faculty of Science, The Hong Kong Polytechnic University, Hong Kong SAR, China
Event Committee
Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche, Universidad Miguel Hernández (UMH), Elche 03202, Spain
Dr. María Herranz-López is a researcher of IDiBE at the UMH within the research group "Design and Development of Bioactive Molecules". Besides being a researcher of several projects of the national plan MINECO, she is PI of a PROMETEO for research groups of excellence to evaluated the capacity of plant polyphenols to regulate appetite, energy balance and/or thermogenesis with the capability to increase gut hormones having appetite-suppressing effects and/or to mimic beige adipocyte phenotype in white fat. In addition, she is PI of a project in public-private collaboration of the State Plan for Scientific and Technical Research and Innovation for the valorisation of insect biomass chitosan to develop new sustainable biobased packaging and cosmetic formulations. She is also PI of a Project funded by the International Center for Aging Research (ICAR) on the Regulation of metabolic stress associated with aging through plant polyphenols, of the “Aid Program for Aging Research of the ICAR Foundation, 2023”. Moreover, she is PI in other regional projects using omics techniques for the characterization of in vitro obesity models, and to study, in an ex vivo experimental model, the behaviour of leukocytes from the blood of patients with type 2 diabetes and evaluate the protective effect of antioxidant metabolites. She is also reviewer at the State Research Agency-AEI since 2021 and is also involved in different scientific leadership activities, creating a national and international network and collaborations that has allowed to apply for several international calls. Recently, she has obtained a grant for the requalification of university teaching staff for a period of one year in the research group in Cardiovascular Pathology that belongs to the Institute of Health and Biomedical Research of Alicante.
obesity, metabolic diseases, adipocytes, natural compounds, polyphenols, oxidative stress, cancer
Departamento of Physiology School of Medicine, Universidad Complutense, 28040 Madrid, CIBERCV, Spain
Ernesto Martínez-Martínez is a permanent Faculty Member at the School of Medicine in Complutense University of Madrid. Dr. Martínez-Martínez combines his teaching tasks with the research as co-leader, with Dr. Victoria Cachofeiro, of the Cardiovascular and Metabolic Physiopathology research group. The interest of the group is the study of the mechanisms involved in the cardiovascular damage associated with several pathologies such as obesity, myocardial infarction, metabolic syndrome, hypertension, cardiorenal syndrome… After his BSc degrees in Chemistry, (2006) and master degree in Biochemistry (2008), Dr. Martínez-Martínez started his thesis focus on “Role of leptin in the cardiovascular alterations associated with obesity: mechanisms involved” under the supervision of Prof. Victoria Cachofeiro. In 2014, joined the Dr López-Andrés group as a Post-Doctoral Researcher and focused his studies in the search of new targets of aldosterone involved in cardiovascular remodeling as well as in valvulopathies. In 2015, Dr. Martínez-Martínez moved to Paris, under Dr Jaisser supervision and continued his research in mineralocorticoid receptor, pathophysiology and therapeutic innovations. This background has allowed over different peer-reviewed publications and book chapters and is member of different editorial boards.
obesity, oxidative stress, mitochondria, endoplasmic reticulum stress, cardiac damage
1. Department of Applied Biology-Nutrition, Institute of Bioengineering, Miguel Hernández University (UMH), 03202 Elche, Spain,
2. Alicante Institute for Health and Biomedical Research (ISABIAL), 03010 Alicante, Spain,
3. CIBER Physiopathology of Obesity and Nutrition/Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain
The connection to the world of Nutrition began with a doctoral thesis on protein metabolism. This thesis was supervised by Dr. D. Santiago Grisolía (a disciple of Nobel Prize winner Dr. D. Severo Ochoa) and Dr. Erwin Knecht (1984-1989). Subsequently, I completed a postdoctoral fellowship with a contract for 8 years in the USA, Switzerland, and Canada, under the direction of Dr. Marc Prentki. During my time in these countries, I focused on aspects related to Nutrigenomics and its implications for diabetes, obesity, and cell therapy (1989-1996). Finally, I returned to Spain in 1996 to the Miguel Hernández University of Elche, where I developed a new line of research centered on Nutrition applied to physical activity, for both athletes and individuals with diabetes or obesity. These lines of research continue to be developed in collaboration with the Bioactive Compounds Group (IDiBE), the Research Center for Sports, and the spin-off NUTRIEVIDENCE within the aforementioned university.
diabetes, pancreatic cells, obesity, nutrition, oxidative stress, physical exercise, polyphenols
Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy
"Federica Pellati is an Associate Professor in Medicinal Chemistry at the University of Modena and Reggio Emilia in Italy, where she is the Principal Investigator of the research group “Natural Products for Medicinal Chemistry”. Her research is dedicated to the study of bioactive natural compounds as new leads in medicinal chemistry. Her interest is focused on the extraction and analysis of molecules from Cannabis sativa L., and on the investigation of their biological activity against hyper-proliferative disorders and central nervous system diseases. She has many international and national research projects and collaborations. In 2022, she has been awarded with the ElSohly Award by CANN for her research on C. sativa. She is the author of more than 110 papers in international scientific journals (h-index = 36 from Scopus), 2 patents and more than 100 congress communications. She is an editorial board member for many international Journals in the areas of medicinal chemistry and pharmaceutical analysis. "
natural products; drug discovery; medicinal chemistry; hyperproliferative disorders; central nervous system (CNS) pathologies
Research Institute of Integrative Life Sciences, Dongguk University, Goyang-si, Republic of Korea
antioxidant activity; bioactive compounds; medicinal plants; functional foods; biomolecules; nanobiotechnology
Department of Pharmacy, “G. d’Annunzio” University of Chieti-Pescara, 66100 Chieti, Italy
Prof. Simone Carradori obtained his PhD in Pharmaceutical Sciences in 2007 from Sapienza University of Rome. Currently, he is working as an Associate professor in Medicinal Chemistry at the Department of Pharmacy, “G. d’Annunzio” University of Chieti-Pescara (Italy). He has produced more than 275 papers, 12 chapters and two patents. His research activity focuses on the design and development of small molecules as enzyme modulators as well as the isolation, characterization, and chemical functionalization of natural compounds to improve their pharmacodynamic or pharmacokinetic properties. He is Editor-In-Chief of “Anti-Cancer Agents in Medicinal Chemistry”. He is also included in the World’s Top 2% Scientists list since 2021 by the scientists at Stanford University.
natural compounds; medicinal chemistry; food chemistry; antioxidants; antimicrobials; anti-inflammatory; anticancer; extraction; bioactive compounds; nutraceutical; well-being; food supplement; functional food
Nutrition and Bromatology Group, Department of Analytical Chemistry and Food Science, Faculty of Science, University of Vigo, E-32004 Ourense, Spain
Miguel A. Prieto holds a multidiscipline graduate record covering disciplines from Agricultural Sciences, Food Science and Technology and Engineering. He completed two Post-Graduate Master courses in Food Science and Technology and Biosystems Engineering, at the University of Vigo (Spain) and the University College Dublin (Ireland). He completed his PhD degree in Food Science Technology at the Institute of Marine Research (IIM-CSIC, Vigo, Spain). Currently, he is an associate professor at the University of Vigo, leading his own independent group. His experience in Food Chemistry and Technology is supported by more than 200 peer-reviewed articles published in journals indexed in Web of Science (Researcher ID G-4516-2011). To date he has achieved a 52 h-index with over 8,400 citations from 2011 to 2024. He has collaborated in 29 research projects (PI in 4 of them) and he holds 5 patents. He has co-authored a total of 306 communications on more than 90 different international and national conferences (see ResearchGate profile). From these 306 contributions 113 are oral presentations and 135 poster communications and he has been invited as plenary speaker in 5 occasions. He is member of the editorial board of different international SCI-journals (JCR), including Food Chemistry Advances, Frontiers in Nutrition, Current Pharmaceutical Design, Food Science & Nutrition, Chemosensors, International Journal of Molecular Sciences and Antioxidants. To date, he is collaborating with 28 PhD students, of which is the main supervisor of 13, and co-supervisor of 15 students.
food chemistry; food technology; bioactive compounds; analytical techniques; natural food products; emerging technologies; green processes; sustainability; chemical engineering; synergy & antagonism; natural and synthetic antioxidants; mathematical modeli
Department of Biochemistry and Crop Quality, Institute of Soil Science and Plant Cultivation—State Research Institute, Puławy, Poland
Full Professor and the former director of the Institute of Soil Science and Plant Cultivation, State Research Institute, Pulawy, Poland. Research interest includes isolation, purification, structural and quantitative determination of plant natural products (saponins, phenolics, glycoalkaloids, glucosinolates, resorcinols, cyanogenic glucosides), natural toxicants of plants - allelopathy, natural pesticides, post-harvest quality of agricultural products, natural antioxidants and anticancerogens, nutraceuticals, biosynthesis of secondary metabolites, food and feed stuff additives, functional food, agronomy, production systems, climate change in relation to agriculture, bioeconomy. Participant/coordinator of the number of EU projects. Former President of the Phytochemical Society of Europe. Member of Polish Academy of Sciences.
chromatography; plant physiology; extraction spectrometry; food chemistry; natural product; chemistry antioxidants
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy
"Monica Rosa Loizzo graduated cum laude in Pharmacy at University of Calabria (Italy) in 1999. PhD in “Methodology for the development of new molecules of pharmacological interest” 2005, at University of Calabria; Master on Clinical Pathology at University of Calabria. From 2002 to 2004 she spent a period of stage at “Centre for Bioactivity Screening of Natural Products” at King’s College London (UK). In 2008 she spent a period of stage in the laboratory of “Area of Food Industries and technologies” of Politecnica delle Marche University (Ancona, Italy). From 18.12.2008 to 29.12.2017 she is researcher in Food Science Technology at Department of Pharmacy, Health Science and Nutrition of University of Calabria. From 30.12.2017 she become Associate Professor. Prof. Loizzo author of 252 research paper, 17 book chapter and 12 Editorial. Her h index is 53. From 2022 she is Coordinator of the master’s degree course in Nutritional Science. Monica Rosa Loizzo got specific abilities on the main separative techniques with use of different detector systems to determine the chemical composition of different food matrix. She got specific abilities on the main spectrophotometric methods to evaluate the health properties by different in vitro methods (antioxidant, hypoglycaemic, hypolipidemic etc.) of phytochemicals rich food. Moreover, her research interest including the influence of technological processes on the overall quality of food with reference to compounds able to prolong the shelf-life (antioxidant, antimicrobial, anti-browning). She has studied also the chemical composition, sensory evaluation and health properties of extra virgin olive oil, wines, liquor, fish products and sausages. She is referee of several national and international Institutions and member of the Management Committee of COST Action “Eurocaroten” until 2020.
food science technology; bioactives from food by-products; evaluation of shelf-life; development of functional foods
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via P. Bucci, Edificio Polifunzionale, 87036 Arcavacata Rende, CS, Italy
Rosa Tundis is an Associate Professor in Pharmaceutical Biology at the Department of Pharmacy, Health and Nutritional Sciences, University of Calabria (Italy). Her research interest is focused on natural compounds. Over the years, she has successfully extracted, purified and characterized several bioactive compounds, mainly including flavonoids and iridoids, from medicinal plants and plant foods and explored their antioxidant, anti-proliferative, hypoglycaemic, antihypertensive, and neuroprotective activities among others. She is an editorial board member for many international Journals including Antioxidants, Plants, and Food Frontiers. She has many international and national collaborations. Her experience in the field of natural products is supported by more than 170 peer-reviewed international papers, more than 100 congress communications, and 14 book chapters. To date she has achieved a 52 h-index with over 9500 citations (Scopus).
natural products; antioxidants; chemical analysis; Mediterranean species; plant bioactivities; agro-food by-products; enzymes inhibition; functional foods
Sessions
S2. Oxidative Stress and Inflammation in Cardiovascular Diseases
S3. Antioxidants in Chronic Disease: From Dietary Prevention to Therapeutic Intervention
S4. Antioxidants Intake and Gut Microbiome
S5. Natural and Synthetic Antioxidants and Antioxidant Enzyme Systems
S6. Antioxidants Extraction, Assay and Industrial Applications
Registration
If you are registering several people under the same registration, please do not use the same email address for each person, but their individual university email addresses. Thank you for your understanding.
Please note that the submission and registration are two separate parts. Only scholars who registered can receive a link to access the conference live streaming. The deadline for registration is 1 April 2025.
Instructions for Authors
Deadline for abstract submission: 8 December 2024
Deadline for abstract acceptance notification: 13 January 2025
Announcement of oral and poster abstract results: 8 February 2025; You will be notified of the acceptance of an oral/poster presentation in a separate email.
Abstract Submission
1. Abstract submissions should be completed online by registering with www.sciforum.net and using the "New Submission" function once logged into the system. No physical submission is necessary.
2. The abstract should include an introduction, methods, results, and conclusion sections, and be within 250-300 words in length.
3. All accepted abstracts will be published in the conference report of IECAN2025 in MDPI’s Proceedings journal (ISSN: 2504-3900) after quality check. If you wish to publish a research article in the journal, please refer to the “Publication Opportunities” Section.
4. All abstracts should be submitted and presented in clear, publication-ready English with accurate grammar and spelling.
5. You may submit multiple abstracts. However, only one abstract will be selected for oral presentation.
6. All abstracts accepted for presentation will be collected in a book of abstracts, which will be published on the website after the conference.
7. The abstracts submitted to this conference must be original and novel, without prior publication in any journals or it will not be accepted to this conference.
1. The submitting author must ensure that all co-authors are aware of the contents of the abstract.
2. Please select only one presenter for each submission. If you would like to change the presenter after submission, please email us accordingly.
Note: We only accept live presentations.
The slot for the oral presentation is 15 minutes. We recommend a 12-minute presentation, leaving about 3 minutes for a Q&A session.
Authors are encouraged to prepare a presentation in PowerPoint or similar software, to be displayed online along with the abstract. Slides, if available, will be displayed directly on the website using the proprietary slide viewer at Sciforum.net. Slides can be prepared in exactly the same way as for any traditional conference where research results are presented. Slides should be converted to PDF format prior to submission so that they can be converted for online display.
Poster Presentation
a. Your submission should include the title, authors, contact details, and main research findings, as well as tables, figures, and graphs where necessary.
b. File format: PDF (.pdf).
c. Size in cm: 60 width x 80 height–portrait orientation.
d. Font size: ≥ 16.
e. Maximum size: 250 M
Authors who wish to present a poster are invited to send it to the conference email at iecan2025@mdpi.com. All posters will be permanently exhibited online in the Poster Gallery.
It is the authors' responsibility to identify and declare any personal circumstances or interests that may be perceived as inappropriately influencing the representation or interpretation of clinical research. If there is no conflict, please state "The authors declare no conflicts of interest." This should be conveyed in a separate "Conflict of Interest" statement preceding the "Acknowledgments" and "References" sections at the end of the manuscript. Any financial support for the study must be fully disclosed in the "Acknowledgments" section.
MDPI, the publisher of the Sciforum.net platform, is an open access publisher. We believe authors should retain the copyright to their scholarly works. Hence, by submitting an abstract to this conference, you retain the copyright to the work, but you grant MDPI the non-exclusive right to publish this abstract online on the Sciforum.net platform. This means you can easily submit your full paper (with the abstract) to any scientific journal at a later stage and tran
We will reach out to you closer to the dates of the conference with more information.
Publication Opportunities
Participants in this conference are cordially invited to contribute a research article to the Special Issue, published in Antioxidants (ISSN: 2076-3921, Impact Factor: 6.0), with a 20% discount on the publication fee. Details of the special issue will be announced here later. Please note that no other discounts are applicable. All submitted papers will undergo MDPI’s standard peer-review procedure. The abstracts should be cited and noted on the first page of the paper.
Manuscripts for the proceedings issue must be formatted as follows:
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Title.
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Full author names.
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Affiliations (including full postal address) and authors' e-mail addresses.
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Abstract.
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Keywords.
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Introduction.
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Methods.
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Results and Discussion.
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Conclusions.
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Acknowledgements.
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References.
Event Awards
To acknowledge the support of the conference's esteemed authors and recognize their outstanding scientific accomplishments, we are pleased to announce that the conference will provide 6 awards including Best Oral Presentation Award and Best Poster Award.
The Awards
Number of Awards Available: 6
The Best Oral Presentation Award is given to the submission judged to make the most significant oral contribution to the conference.
The Best Poster Award is given to the submission judged to make the most significant and interesting poster for the conference.
There will be six winners selected for these awards. The winner will receive a certificate and 200 CHF each.
Sponsors and Partners
For information regarding sponsorship and exhibition opportunities, please click here.
Organizers
Media Partners
Conference Secretariat
Ms. Miya Wu
Ms. Leong Jin Yue Esther
For inquiries regarding submissions and sponsorship opportunities, please feel free to contact us.
Email: iecan2025@mdpi.com
S1. Oxidative Stress in Obesity
Session Chairs
Prof. Dr. Vicente Micol, Instituto de Investigación, Desarrollo e Innovación en Biotecnologia Sanitaria at Miguel Hernández University, Elche, Spain
Prof. Dr. Victoria Cachofeiro, Physiology Department, School of Medicine, Universidad Complutense, Madrid, Spain
S2. Oxidative Stress and Inflammation in Cardiovascular Diseases
Cardiovascular diseases are the leading cause of death worldwide, and the risk factors include smoking, high blood pressure, diet, high cholesterol, and diabetes. Oxidative stress and inflammation are intricately linked mechanisms and are significant drivers in the development and progression of cardiovascular disease.
Cardiovascular oxidative damage occurs when endogenous antioxidant levels are too insufficient to significantly reduce high levels of reactive oxygen species (ROS) and associated free radicals. ROS are associated with the pathophysiology of many cardiovascular diseases (CVDs), including cardiac hypertrophy, cardiomyopathy, heart failure, ventricular remodeling, and myocardial infarction. Due to its high energetic demand, the heart has the highest rate of production of ROS, yet in comparison to other mammalian organs the heart has a significantly lower level of antioxidants and total antioxidant enzyme activities. Homeostatic mechanisms that balance ROS generation, antioxidant production, and consumption in CVDs require fine-tuning for optimal therapeutic outcomes.
Some of the key topics that will be covered in this session include the role of oxidative stress and inflammation in the pathogenesis of cardiovascular diseases, the impact of lifestyle factors such as diet and smoking on cardiovascular health, and the potential therapeutic strategies targeting oxidative stress in the treatment of CVDs. We hope that this session will stimulate further discussion and collaboration among researchers and healthcare professionals in the ongoing efforts to combat cardiovascular diseases.
Session Chair
Prof. Dr. Aldrin V. Gomes, 1. Department of Neurobiology, Physiology, and Behavior, University of California, One Shields Ave., Davis, CA 95616, USA 2. Department of Physiology and Membrane Biology, University of California, Davis, CA 95616, USA
S3. Antioxidants in Chronic Disease: From Dietary Prevention to Therapeutic Intervention
Chronic diseases, most notably diabetes, cancer, cardiovascular diseases, neurodegenerative diseases, thyroid diseases, and allergic diseases, are major causes of death, disability, and a lower quality of life in various populations. Oxidative stress, defined as an imbalance between the production of pro-oxidants (reactive oxygen, nitrogen, and chlorine species) and the body’s production of antioxidants (enzymatic, e.g., superoxide dismutase, glutathione peroxidase, and catalase, and non-enzymatic, e.g., glutathione, uric acid, melatonin, metal-binding proteins, bilirubin, and polyamines), plays an important role in the pathogenesis of these diseases. Lifestyle modifications, including a healthy diet, are a major therapeutic strategy in preventing and treating chronic diseases.
This session will provide insights into the complex relationship between oxidative stress, lifestyle factors, and chronic disease risk, and offer practical strategies for promoting health and well-being through dietary and lifestyle interventions.
Session Chairs
Prof. Dr. Jiankang Liu, 1. School of Health and Life Sciences, University of Health and Rehabilitation Sciences, Qingdao, China 2. School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China
Dr. Raul Zamora-Ros, Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain
S4. Antioxidants Intake and Gut Microbiome
The gut is a complex microecosystem. The inter-relationship between the gut microbiome and a host determines the key physiological processes of the body's metabolism. There is a bidirectional mechanism between the gut microbiome and stress. Oxidative stress causes the imbalance of the gut microbiota and harmful bacteria translocation, which cause a series of diseases. The gut microbiota and some of their metabolites are beneficial for the body's antioxidant capacity.
More and more studies have confirmed that antioxidants (probiotics, vitamins, and plant extract with antioxidant properties) can alleviate intestinal oxidative stress, regulate the composition of gut microbiota, improve the disorder of gut microbiota, and improve the antioxidant capacity of the body.
This session will provide insights into the health benefits of major dietary antioxidant groups, and examine in depth the interaction of gut microbiota with these dietary antioxidants with various preclinical and human dietary interventions.
Session Chair
Prof. Dr. José Ángel Rufián-Henares, Departamento de Nutrición y Bromatología, Facultad de Farmacia, Universidad de Granada, Spain
S5. Natural and Synthetic Antioxidants and Antioxidant Enzyme Systems
Reactive oxygen and nitrogen species (RONS) play a key role in the regulation of cell survival. Indeed, while adequate levels of RONS are essential to sustain cell proliferation and survival, the disruption of the endocellular redox state induces cell dysfunction and death.
First considered ‘health-promoting’ by virtue of their radical scavenging activity and/or direct antioxidant effects on cellular biomolecules, antioxidants are now believed to be able to interfere with cell signal transduction by intercepting reactive species at the level of critical signalling pathways. In addition, the interaction of these molecules with signalling enzymes, receptors, and transcription factors has emerged recently.
Along these lines, understanding the mechanisms underlying cellular redox homeostasis may help to develop antioxidant-based pharmacological combotherapies to counteract the development of a wide number of redox-dependent pathologies, including cardiovascular, neurodegenerative, and inflammatory-based diseases as well as cancer.
In this session, we welcome extensive studies on raw materials as a valuable source of natural antioxidant compounds, by focusing on the optimization of the methodologies to extract, purify, and stabilize them. Moreover, contributions aimed at evaluating the mechanisms through which antioxidant compounds, of both natural and synthetic origin, may improve human health will also be presented.
Session Chair
Dr. Mario Allegra, Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche, Università degli Studi di Palermo, Palermo, Italy
S6. Antioxidants Extraction, Assay and Industrial Applications
Increasing consumer awareness regarding the use of natural antioxidants has led to exploring new natural sources of these compounds. As such, by-products obtained from the agri-food industry constitute an important source of natural antioxidants.
Prior to commercialization at the industrial level, it is first necessary to extract such antioxidants using, if possible, green extraction methods. Secondly, the antioxidants obtained must be characterized considering that their biological activity differs if they are alone or in a matrix. For this purpose, both screening (e.g., spectrophotometric techniques) as well as advanced analysis techniques, including the use of liquid or gas chromatography, coupled with mass detectors, triple quadrupole, etc., will be necessary.
Once the compounds are characterized in a global or individualized way, studies are necessary to demonstrate their safety (e.g., cytotoxicity studies), antioxidant effect, and/or other bioactivities. In vitro and in vivo bioavailability and bioavailability tests will also be required considering the application, since these may be included in active packaging for food, function as food
additives, or be used for different purposes. Furthermore, the encapsulation of antioxidants by food micro-/nano-technologies is also widely used to enhance their bioavailability and/or bioactivities.
In this session, we will cover the following: i) extraction of antioxidants; ii) analysis of antioxidants; iii) in vitro and in vivo cytotoxicity and bioactivity evaluation; iv) in vitro and in vivo bioaccessibility and bioavailability evaluation; v) antioxidants used in food packaging; vi) encapsulation of antioxidants and related applications; and vii) patents and commercial applications.
Session Chair
Dr. Ren-You Gan, Department of Nutrition, Singapore Institute of Food and Biotechnology Innovation (SIFBI), Agency for Science, Technology and Rese, Singapore