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IJMS | Nitric Oxide: Physiology, Pharmacology, and Therapeutic Applications

17–18 Nov 2020

Pharmacology, Physiology, Nitric Oxide
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Welcome from the Chair

17- 18 November 2020, VIRTUAL, Welcome from the Conference Chair

Nitric oxide (NO), a gaseous free radical, is one of the ten smallest molecules found in nature. Although toxic, it is recognized to be a gasotransmitter that plays multiple roles in normal physiology. NO regulates vascular relaxation, controls inflammation, and suppresses expression of pro-inflammatory mediators in mast cells, macrophages, vascular smooth muscles, affects metabolism, insulin resistance, and has a role in type-2 diabetes.

In this webinar, over a 2-day period, we will hear updates from some of the experts in this interesting, still evolving, and at time controversial field.

In 1992, the journal Science referred to NO as the “Molecule of the Year”. The important role that NO plays in human biology was recognized in 1998 when the Nobel Prize in Physiology and Medicine was awarded to Robert F. Furchgott, Louis J. Ignarro, and Ferid Murad for establishing NO as a messenger molecule. The past 30 years have been very fruitful in deciphering the role of NO in human physiology, with many questions still on the horizon.

We are pleased to sponsor this 2-day webinar on the various aspects of NO physiology, pharmacology, and therapeutic applications and would like to welcome all the participants.

This Webinar relates to the Special Issue Nitric Oxide: Physiology, Pharmacology, and Therapeutic Applications. Participants will have the opportunity to contribute with a manuscript to the special issue with a special discount of 20%.

Organized by Khosrow Kashfi, PhD, FRSC, FRSB

City University of New York School of Medicine, New York, USA
City College of New York, NY, USA
Graduate Program in Biology, CUNY Graduate Center, NY, USA

Date: 17-18 November 2020

Time: 14.30pm (CET) | 8.30am (EST)

Chair: Professor Khosrow Kashfi

Webinar ID: 999 0782 5213

Webinar secretariat:

Conference Chair

City University of New York School of Medicine, New York, USA• City College of New York, NY, USA• Graduate Program in Biology, CUNY Graduate Center, NY, USA


Keynote Speakers

Laboratory of Cancer Immunometabolism Senior Investigator Head, Molecular Mechanisms Section Acting Deputy Chief Center for Cancer Research National Cancer Institute, Frederick, MD, USA


Professor of Experimental Therapeutics University of Exeter Medical School Exeter, England



Department of Biology, Tor Vergata University of Rome, Rome, Italy; Redox Signaling and Oxidative Stress Group, Danish Cancer Society Research Center, Copenhagen, Denmark


Discipline of Pathology, Lambe Institute for Translational Research, School of Medicine, National University of Ireland Galway, Ireland


Institute of Biomedicine of Seville (IBIS), IBiS/Hospital University “Virgen del Rocío”/CSIC/University of Seville, Seville, Spain


Redox Signaling and Oxidative Stress group Danish Cancer Society Research Center Copenhagen, Denmark


Department of Pharmacology, Ribeirao Preto Medical School, University of São Paulo, SP, Brazil


Principal Investigator, Vascular Medicine Institute, Co-Director, Center for Metabolism and Mitochondrial Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA• Editor, Nitric Oxide


Departments of Chemistry and Biology The College of Staten Island City University of New York, NY, USA


PhD Student Department of Cancer Biology College of Medicine & Life Sciences The University of Toledo, Toledo, OH, USA


Director of Endocrine Physiology Research Center Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran


School of Pharmacy and Biomolecular Sciences, University of Brighton, Centre for Stress and Age-related Disease, Moulsecoomb, Brighton, England


Unit of Molecular Metabolism, Department of Clinical Sciences Lund University, Malmö, Sweden


Department of Pharmacology & Chemical Biology University of Pittsburgh School of Medicine, Pittsburgh, PA, USA


Center for Vascular Biology Research Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA, USA


Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, USA


The Solomon H. Snyder Department of Neuroscience Johns Hopkins University School of Medicine Baltimore, MD, USA


Webinar Content

On Tuesday and Wednesday, 17/18 November 2020, MDPI and IJMS organized the first virtual conference on IJMS, entitled: “Nitric Oxide: Physiology, Pharmacology, and Therapeutic Applications"

The introduction was held on both days by the chair of the webinar, Dr. Khosrow Kashfi. Dr. Khosrow Kashfi is an Associate Medical Professor of Pharmacology at the City University of New York School of Medicine, a 7-year BS-MD program that is focused on producing broadly-educated, highly-skilled medical practitioners to provide quality health services to communities historically underserved by primary care practitioners.

The webinar was offered via Zoom and required registration to attend. The full recording can be found here on Sciforum website. In order to stay updated on the next webinars on IJMS, be sure to sign up for our newsletter by clicking on “Subscribe” at the top of the page.

Day 1:

Day 2:

Program 17 November: Day 1: NO in cancer, cardiovascular, and the immune system

Speakers/Presentations Time EST Time CET

Khosrow Kashfi

Opening Remarks

8:30am 2.30pm

David A. Wink

Keynote Speaker

9:00am 3.00pm

Giuseppe Filomeni

Redox activation of ATM modulates S-nitrosylation and mitophagy: effects on immune cell activation

10:00am 4.00pm

Sharon Glynn

Influence of nitric oxide on prostate cancer initiation and progression

10:25am 4.25pm

Melanie Flint

Stress hormone signaling and breast cancer metastasis; the potential
therapeutic benefit of NOS inhibition

10:50am 4.50pm

Salvatore Rizza

Exploiting S-nitrosylation for cancer therapy: facts and perspectives

11:15am 5.15pm

Asghar Ghasemi

Nitrate and nitrite for management of type 2 diabetes: Translation from
animals to humans

11:40am 5.40pm

Sruti Shiva

Nitrite activates PKA to regulate cardiomyocyte function

12:05pm 6.05pm

Probal Banerjee

Exploiting the Diverse Roles of Nitric Oxide Synthase Isozymes

12:30pm 6.30pm

Roshale Fernando

Normalizing arginine metabolism in tumor associated macrophages: A novel immunotherapeutic strategy for breast cancer

12:55pm 6.55pm

Program 18 November: Day 2: NO in metabolic syndrome, insulin resistance, type-2 diabetes, and beyond


Speakers/Presentations Time EST Time CET

Khosrow Kashfi

Opening Remarks

08:30am 14.30pm

Thiago Cunha

NO signaling mediates peripheral analgesia

09:00am 15.00pm

Jordi Muntané

Relevance of NO downregulation during the treatment of liver cancer with Sorafenib

09:25am 15.25pm

Sevda Gheibi

Hydrogen sulfide potentiates the favorable metabolic profile of inorganic nitrite in type 2 diabetes

09:50am 15.50pm

Carola Neumann

Nitroalkenes and cancer: an update on anti-cancer drug development efforts

10:15am 16.15pm


10.40am 16.40pm

Dipak Panigrahy

Inflammation Resolution in Cancer

10:55am 16.55pm

Douglas Thomas

Nitric oxide; the new architect of epigenetic landscapes

11:20am 17.20pm

Bindu D. Paul

Role of nitrosylation and sulfhydration in aging and neurodegeneration

11:45am 17.45pm

Khosrow Kashfi

NOSH-aspirin (NBS-1120), a multitarget inhibitor for the treatment of
inflammatory diseases: Rationale, biological evaluation and molecular
modeling studies

12:10pm 18.10pm

Relevant Special Issue

Special Issues in IJMS

Nitric Oxide: Physiology, Pharmacology, and Therapeutic Applications
Guest Editor: Prof. Dr. Khosrow Kashfi
Deadline for manuscript submissions: 30 April 2021.

Endogenous Gaseous Signaling Molecules: Their Mechanism(s) of Action and Pharmacological Effects
Guest Editor: Dr. Marcin Magierowski, Prof. Dr. Binghe Wang
Deadline for manuscript submissions: 30 April 2021

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