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JCM Webinar | Updates on Cardiac and Vascular Toxicities from Antineoplastic Drugs

Part of the Webinars on Clinical Medicine series
7 July 2025, 16:00 (CEST)

Registration Deadline
7 July 2025

Cardiotoxicity, Cardio-oncology, Metabolism, Heart Failure
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Welcome from the Chairs

Dear Colleagues,

With the improvements in cancer prognosis thanks to advances in anti-cancer treatment protocols and new targeted therapies and immunotherapies, we are witnessing an increase in survival; however, at the same time, an increase in morbidity has also been observed among cancer survivors as a consequence of the increased cardiovascular adverse effects of anti-cancer drugs.

This is often the consequence of mechanisms that are still partly unknown, which prevent the development of preventative and curative therapies that target the specific cardio- and vasculotoxic effects of anti-cancer therapies.

In this webinar, we will discuss the new frontiers of cardio-oncology research, the mechanisms and implications of hidden cytotoxicity, and the metabolic roots of anthracycline-induced cardiotoxicity. These topics will be covered by world-class experts in the field.

The webinar will be introduced by an opening greeting from Prof. Dr. Rosalinda Madonna, together with the co-chair Prof. Dr. Luca Liberale.

Date: 07 July 2025 at 4:00 p.m. CEST | 10:00 a.m. EDT | 10:00 p.m. CST Asia
Webinar ID: 844 5419 3422
Webinar Secretariat: journal.webinar@mdpi.com

Registration

Please note that institutional and academic email addresses are prioritized. Therefore, we would like to recommend that you register with your academic or institutional mail address.

Certificates of attendance will be available to those who attend the live webinar.

Unable to attend? Register anyway and we will inform you when the recording is available.

Event Chairs

Cardiology Division, Department of Pathology, University of Pisa, Italy

Introduction
Bio
Degree in Medicine and Surgery, Master in Internal Ultrasound, Ph.D. in Biotechnology and Functional Bioimaging, Specialization in Cardiology, Honorary Researcher at the University “G. D'Annunzio "Chieti-Pescara; Research Fellow and Adjunct Assistant Professor at the University of Texas Medical School in Houston, TX, and the Institute of Molecular Cardiology, University of Louisville, KY; Research Scientist at the Texas Heart Institute, Houston, TX; Senior Research Scientist at the University of Pisa. Current: Associate Professor in Cardiology, University of Pisa; consultant cardiologist, University Cardiology 1, Cisanello Hospital, Pisa; qualified as Full Professor in Cardiology and Full Professor in Sciences of the health profession and applied medical technologies.

Department of Internal Medicine and Medical Specialties – DIMI, University OF Genova, Italy,
IRCCS Ospedale Policlinico San Martino, Genova, Italy

Introduction
Bio
Prof. Luca Liberale obtained his MD degree at the University of Genoa in 2012, followed by a specialization in Internal Medicine in 2018 and a PhD in 2021. Between 2017 and 2021, he conducted research on aging, arterial thrombosis, and stroke at the Center for Molecular Cardiology of the University of Zurich, Switzerland, led by Prof. Giovanni Camici and Thomas Lüscher. At the end of 2021, he returned to the University of Genoa, where he is now an Associate Professor and Consultant Internist at San Martino University Hospital. His research focuses on the role of inflammation in cardiovascular diseases and key risk factors, including obesity and aging. Prof. Liberale serves as an editor for different journals, such as the European Heart Journal, the International Journal of Cardiology, and the European Journal of Clinical Investigation. He has published over 190 articles (H-index of 34, >5000 citations in Scopus), is active in multiple scientific societies, and coordinates communications for the WG on Atherosclerosis and Vascular Biology of the European Society of Cardiology. His work has been awarded by different national and international societies.

Keynote Speakers

Department of Internal Medicine and Medical Specialties – DIMI, University OF Genova, Italy,
IRCCS Ospedale Policlinico San Martino, Genova, Italy

Introduction
Talk
Perspectives in Cardio-Oncology Research
Bio
Pietro Ameri, MD, PhD, is an Associate Professor in Cardiovascular Diseases and a Coordinator of the Translational and Clinical PhD program at the University of Genova, Italy. He also leads a translational research unit, the heart failure outpatient program, and the cardio-oncology service at the affiliated IRCCS San Martino Policlinic Hospital. He is currently the Secretary of the ESC Council of Cardio-Oncology, the local chairperson of the upcoming ESC 2025 Cardio-Oncology Conference, and a Member of the Scientific Committee on Basic & Translational Research of the ESC Heart Failure Association. He is the Cardiovascular Oncology Section Editor of the Journal of Thrombosis and Thrombolysis and an Associate Editor of the Journal of Cellular and Molecular Medicine. His primary interests are heart failure and cardio-oncology, especially with respect to the interplay between heart failure, cancer, and cancer treatments. Pietro Ameri's research group includes biologists, biotechnologists, and physicians and is funded by several grants. His H-index is 38.

Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary

Introduction
Talk
Hidden Cardiotoxicity of Drugs: A Paradigm Shift in Cardiac Safety Testing
Bio
Prof. Dr. Péter Ferdinandy has been recognized as a Highly Cited Researcher in 2014, 2017, 2020, 2021, 2022, 2023, and 2024. He has published more than 350 papers and 6 patent families. His Hirsch index is 69. He received his MD in 1991 and his PhD in 1995 at the University of Szeged, Hungary. He received postdoctoral training at the University of Alberta, Edmonton, Canada, from 1997 to 1999. He became a registered clinical pharmacologist in 1999. He received his MBA in finance and quality management in 2004 from the Budapest University of Technology and Economics. He founded the Pharmahungary Group, a group of R&D companies (www.pharmahungary.com) that have been involved in more than 250 drug/medical device development projects since their foundation in the early 2000s. He was the president of the International Society for Heart Research, European Section, and the chair of the Working Group of Cellular Biology of the Heart of the European Society for Cardiology. Currently, he is the vice-rector for science and innovations and the director of the Department of Pharmacology and Pharmacotherapy, at Semmelweis University, Budapest (www.semmelweis.hu). He is the president of the Hungarian Society of Experimental and Clinical Pharmacology (www.huphar.org) and serves as the Editor-in-Chief of the British Journal of Pharmacology.

Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center “Guido Tarone”, University of Torino, Torino, Italy

Introduction
Talk
Doxorubicin Cardiotoxicity and Cardiac Metabolic Rewiring
Bio
Prof. Dr. Emilio Hirsh is a Professor of Cell Biology at the University of Torino Medical School and Director of the Molecular Biotechnology Center. He is an EMBO and ISHR Fellow. His research has shaped our understanding of phosphoinositide 3-kinases (PI3Ks) as multifunctional signaling and scaffolding proteins, with major contributions in cancer, inflammation, metabolic diseases, and heart failure. He has authored over 300 peer-reviewed publications with >30,000 citations and an H-index of 97 (Google Scholar). He pioneered PI3K isoform-selective targeting, generated the first PI3K- knockout mice, and contributed to the discovery of PI3Kγ inhibitors now in clinical development. He also uncovered key functions of PI3KC2α in endocytosis, primary cilia, mitosis, and cytokinesis (Nature 2013; Cancer Cell 2017; Science 2021). He is the founder of the biotech company Kither Biotech, and he holds several patents on PI3K-targeted therapies, including compounds in clinical trials. He has received funding from the Human Frontier Science Program, EU FP5-FP6, Leducq Foundation, and AIRC, and he is the recipient of the ISHR Outstanding Scientist Award. He has served on the Scientific Boards of Celzome AG, DZHK, and AIRC, and was a consultant for Merck-Serono. He has organized several international meetings (Keystone, FASEB, EMBO) and has given >100 invited lectures at major institutions and conferences worldwide. Editorial boards: Cardiovascular Research (Associate Editor), Frontiers in Oncology, Cancers, Cell Communication & Signaling, Cancers.

Program

Speaker/Presentation

Time in CEST

Prof. Dr. Rosalinda Madonna and Prof. Dr. Luca Liberale
Chair Introduction
4:00 pm - 4:10 pm
Prof. Dr. Pietro Ameri
Perspectives in Cardio-oncology Research
4:10 pm - 4:30 pm
Prof. Dr. Peter Ferdinandy
Hidden Cardiotoxicity of Drugs: A Paradigm Shift in Cardiac Safety Testing
4:30 pm - 4:50 pm
Prof. Dr. Emilio Hirsch
Doxorubicin Cardiotoxicity and Cardiac Metabolic Rewiring
4:50 pm - 5:10 pm
Q&A Session 5:10 pm - 5:25 pm
Prof. Dr. Rosalinda Madonna and Prof. Dr. Luca Liberale
Closing of Webinar
5:25 pm - 5:30 pm

Relevant Special Issue

Clinical Updates on Cardiac and Vascular Toxicities from Antineoplastic Drugs and Beyond
Guest Editor: Prof. Dr. Rosalinda Madonna
Deadline for Manuscript Submissions: 10 July 2025

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