webinar

Molecules Webinar | Synthesis and Identification of Small Compounds Active in Neurodegeneration

Name: Molecules Webinar | Synthesis and Identification of Small Compounds Active in Neurodegeneration
Start: 2021-06-17T17:00:00
End: 2021-06-17T17:00:00

17 June 2021

17:00

Online

Meet Our Speakers

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Dr. Barbara De Filippis

University of Chieti, Italy;
Dr. Barbara De Filippis has a degree in Pharmaceutical Chemistry and Technology and earned her PhD in Medicinal Chemistry Sciences at the University of Chieti (Italy), where she is currently an Assistant Professor of Medicinal Chemistry. Her main expertise deals with the design and synthesis of stilbene derivatives with multiple pharmacological potential. Over the past several years, the principal interest of Dr. De Filippis’ research group was related to the studies of PPARs involved in metabolic diseases [e.g., B. De Filippis et al., Structural development studies of PPARs ligands based on tyrosine scaffold, European Journal of Medicinal Chemistry, 89, 817-825, 2015; B. De Filippis et al., In vitro protective effects of resveratrol and stilbene alkanoic derivatives on induced oxidative stress on C2C12 and MCF7 cells. J Biol Regul Homeost Agents 31(3), 589-601, 2017] and the synthesis of fibrate derivatives with different isoform selectivity. Her current research interests have shifted toward the design and the synthesis of natural polyphenol derivatives, in particular resveratrol and caffeic acid, with their anticancer, antioxidant and antimicrobial biological activities, among others [e.g., B. De Filippis et al., Synthesis and cytotoxic effects on pancreatic cancer cells of resveratrol analogs. Medicinal Chemistry Research 28, 984-991, 2019; B. De Filippis et al., Synthesis and Biological Evaluation of Halogenated E-Stilbenols as Promising Antiaging Agents. Molecules 2020, 25, 5770; B. De Filippis et al., Searching for new tools to counteract the Helicobacter pylori resistance: the positive action of resveratrol derivatives. Antibiotics, 2020 9, 891]. She has co-authored more than 60 scientific articles.

Sponsors and Partners

Organizer

Webinar Content

On Thursday, 17 June 2021, MDPI and the Journal Molecules organized the 11th webinar, entitled "Synthesis and Identification of Small Compounds Active in Neurodegeneration".

The introduction was held by the Chair of the webinar, Dr. Barbara De Filippis from the University of Chieti, Italy. She also held the first presentation entitled "Stilbene, a Useful Scaffold in the Design of Neuroprotective Agents"

The second presentation with the title "Microtubule Stabilizing Triazolopyrimidines as Potential Candidates for the Treatment of Alzheimer’s Disease and Related Tauopathies" was held by Prof. Dr. Carlo Ballatore, from the University of California San Diego (UCSD), USA.

Prof. Dr. Richard B. Silver was the third presenter of the webinar and discussed protein aggregation and the development of therapeutics for Upper Motor Neuron Diseases. Dr. Richard B. Silverman is the Patrick G. Ryan/Aon Professor in the Departments of Chemistry, Molecular Biosciences, and Pharmacology, Northwestern University, U.S.A.

The fourth presentation, entitled "Coumarin-Inspired Hybrids as Promising Agents against Neurodegenerative Diseases" was held by Prof. Dr. Maria João Matos. Dr. Matos is a Researcher in Medicinal Chemistry at the Department of Chemistry and Biochemistry, University of Porto, and a Visitor at the Faculty of Pharmacy, University of Santiago de Compostela.

The last presentation with the title "Mitochondrial Dysfunction as a Target for New Compounds against Alzheimer’s Disease" was held by Prof. Dr. Gunter P. Eckert from the Justus-Liebig-University Giessen, Germany.

The presentations were followed by a Q&A and a discussion, moderated by the Chair. The webinar was offered via Zoom and required registration to attend. The full recording can be found here on Sciforum website. In order to stay updated on the next webinars on Cells, be sure to sign up for our newsletter by clicking on “Subscribe” at the top of the page.

Relevant SI

Synthesis and Identification of Small Compounds Active in Neurodegeneration in Molecules
Synthesis and Identification of Small Compounds Active in Neurodegeneration in Chemistry
Guest Editor: Dr. Barbara De Filippis
Co-Guest Editor: Prof. Dr. Gunter P. Eckert
Deadline for manuscript submissions: 30 September 2021