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Molecules Webinar | Frontiers in Nucleic Acid Chemistry—in Memory of Professor Enrique Pedroso for His Outstanding Contributions to Nucleic Acid Chemistry

13 Jan 2022, 16:00 (CET)

SiRNA, Gene Silencing, G Quadruplex, DNA Nanotechnology, Aptamers, Drug Delivery, DNA, RNA, Oligonucleotide Synthesis
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Welcome from the Chair

28th Molecules Webinar

Frontiers in Nucleic Acid Chemistry—in Memory of Professor Enrique Pedroso for His Outstanding Contributions to Nucleic Acid Chemistry

Nucleic Acid Chemistry started soon after the Watson–Crick model of DNA with the synthesis of the first dinucleotide, published in 1955. However, in the last decade, this field has blossomed, with the demonstration that Nucleic Acid Chemistry can provide innovative solutions to new and old health problems such as vaccination, pathogen detection, and the treatment of metabolic or genetic diseases as well as providing important tools for the interrogation of cellular mechanisms. In this webinar, we would like to offer a few examples of the novel developments in Nucleic Acid Chemistry and, at the same time, honour the memory of Prof. Enrique Pedroso, one of the pioneering researchers in Nucleic Acid Chemistry in Spain. His contributions to the synthesis of modified oligonucleotides, and especially oligonucleotide conjugates and cyclic oligonucleotides, opened new avenues in the search for novel applications of oligonucleotides. In addition, Enrique was deeply involved in the research and promotion of nucleic acid chemistry, as an active member of the IRT Society as well as organizing the Spanish Nucleosides Nucleotides and Nucleic Acids meetings (RANN). The webinar will be a tribute to his memory and a showcase of this highly interdisciplinary discipline that combines organic chemistry, biochemistry, pharmacology, materials chemistry and biophysics.

Date: 13 January 2022

Time: 4:00pm CET | 10:00am EST | 11:00pm CST Asia

Webinar ID: 841 1006 6845

Webinar Secretariat: molecules.webinar@mdpi.com

Chair

Institute for Advanced Chemistry of Catalonia (IQAC), Consejo Superior de Investigaciones Científicas (CSIC), CIBER-BBN, Barcelona, Spain - Website

DETAILS
Bio
Ramon Eritja is a research professor at the Institute for Advanced Chemistry of Catalonia (IQAC) of the Spanish National Research Council (CSIC) located in Barcelona, Spain. He is also a staff member at the Spanish Nanomedicine Network (CIBER-BBN). He is the group leader of the Nucleic Acid Chemistry group at IQAC and scientific director of Nanbiosis oligonucleotide synthesis platform, U29. Ramon is most interested in the development of a methodology for the synthesis of modified oligonucleotides for therapeutic and diagnostic uses, as well as the study of the properties of non-canonical nucleic acid structures such as G-quadruplex, triplex and i-motif. Recently, he became interested in the development of DNA biosensors for viral RNA detection and the functionalization of DNA origami to enhance their biomedical properties.

Invited Speakers

Department of Chemical Sciences, University of Naples Federico II, Napoli, Italy - Website

DETAILS
Bio
Daniela Montesarchio is Professor of Organic Chemistry at Federico II University of Naples, where she graduated with honors with a Chemistry degree in 1989. In 1993, she obtained her Ph.D. in Chemical Sciences with a thesis on the chemical synthesis of modified oligonucleotides and nucleoside analogues (supervisor Prof. Ciro Santacroce). After her postdoctoral experience in the laboratories of Prof. George Just in McGill University, Montréal, she came back to Federico II University, where, in 1994, she became Assistant Professor and, since 2005, has been an Associate Professor. Her research interests are mainly devoted to the design and synthesis of hybrid systems at the interface between chemistry and biology, including oligonucleotide, nucleoside analogues, aptamers, peptido- and glycomimetics, as well as metal-based drugs for therapeutic/diagnostic applications. In the field of nucleic acid chemistry, her most recent efforts have focused on non-canonical DNA structures, and particularly on the synthesis, modification and characterization of G-quadruplex-forming aptamers, as well on the search for selective ligands for cancer-related telomeric and oncogenic G-quadruplex structures, as potential anticancer drugs.

Department of Inorganic and Organic Chemistry, Organic Chemistry Section, Faculty of Chemistry, University of Barcelona, Barcelona, Spain - Website

DETAILS
Bio
Montserrat Terrazas’ professional career has been focused on the design and synthesis of chemically modified nucleosides, nucleotides and oligonucleotides of structural and biological interest. She graduated with a degree in Chemistry in 2001 from the University of Barcelona and obtained her PhD in Organic Chemistry from the same University (2006) under the supervision of Prof. Xavier Ariza and Prof. Jaume Vilarrasa, where she worked on the development of synthetic methodologies for the specific labelling of nucleosides with 15N, and on the computational design of new anti-HIV-1 nucleosides. After a 3-month stay at the University of Siena (Prof. Maurizio Botta’s group), she joined Prof. Piet Herdewijn’s research group (University of Leuven, Belgium) to work as a postdoctoral fellow on the development of new nucleotide triphosphate derivatives. In 2007, she moved to Stanford University (Prof. Eric T. Kool’s group) to perform a second postdoctoral stay, focused on a research area of great impact in the field of therapeutic oligonucleotides, which forms the basis of her present line of research: the development of new chemical modifications aimed at improving the biological properties of siRNAs, among other therapeutic oligonucleotides. In 2009, she joined Prof. Ramon Eritja’s group (IQAC, CSIC, Barcelona), and in 2013 she was awarded a Miguel Servet Grant to join Prof. Modesto Orozco’s group at the IRB Barcelona, where she started her own research line focused on the design and synthesis of new forms of therapeutic siRNA tools to overcome drug resistance in cancer. In 2021, she joined the Organic Chemistry Section of the Faculty of Chemistry at the University of Barcelona as Associate Professor, where she is developing new multifunctional oligonucleotide-based tools for the treatment of diseases involving multiple targets, as well as new delivery systems for the selective administration of oligonucleotide-based drugs to the tumor.

Registration

This is a FREE webinar. The number of participants to the live session is limited but the recording will be made available on Sciforum shortly afterwards. Registrations with academic institutional email addresses will be prioritized.

Webinar Content

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Program

Speaker/Presentation

Time in CET

Prof. Ramon Eritja

Chair Introduction

4:00 - 4:10 pm

Prof. Daniela Montesarchio

Chemically Modified G-Quadruplex Forming Aptamers in Biomedical Research

4:10 - 4:40 pm

Dr. Montserrat Terrazas

Development of Rationally Designed Oligonucleotide Tools for Combined Cancer Therapy

4:40 - 5:10 pm

Prof. Ramon Eritja

Developing DNA Nanostructures for Drug Delivery

5:10 - 5:40 pm

Q&A Session

5:40 - 5:55 pm

Closing of Webinar
Prof. Ramon Eritja

5:55 - 6:00 pm

Relevant SI

Frontiers in Nucleic Acid Chemistry—In Memory of Professor Enrique Pedroso for His Outstanding Contributions to Nucleic Acid Chemistry
Guest Editors: Prof. Ramon Eritja, Prof. Daniela Montesarchio & Dr. Montserrat Terrazas
Deadline for manuscript submissions: 30 May 2022

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