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Molecules Webinar | Recent Advances in Redox Active Species

28 Nov 2024, 09:00 (CET)

redox active species, nitrogen, sulfur, selenium, photoresponsive nitric oxide-releasing systems, disease mechanisms and therapeutic strategies
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Welcome from the Chair

Join us for an insightful journey through the latest breakthroughs in redox active species. This webinar will explore the diverse roles of reactive nitrogen, sulfur, and selenium species in cellular processes, highlighting their dual nature as both damaging agents and crucial signaling molecules.

Leading experts will discuss how these reactive species are transforming our understanding of disease mechanisms and therapeutic strategies. Our speakers will showcase innovative research, such as photoresponsive nitric oxide-releasing systems for controlled modulation of reactive species in vivo, and the potential of selenotriazines for neuroprotection and Alzheimer's disease treatment.

In addition to the valuable talks, we will allocate time for an interactive discussion between the chair and the speakers, allowing for an engaging dialogue that includes insights and questions from the audience. Discover how advancements in redox biology are paving the way for new medical applications and fostering collaboration in this dynamic field.

Date: 28 November 2024
Time: 09:00 am CET | 04:00 pm CST (Asia)

Webinar ID: 828 3448 2893

Webinar Secretariat: journal.webinar@mdpi.com

Event Chair

Division of Bioorganic Chemistry, School of Pharmacy, Saarland University, Germany

Introduction
Bio
Claus Jacob is a German scientist functioning as the Head of Bioorganic Chemistry, at the School of Pharmacy, Saarland University. He received his B.Sc.(Hons) 1st class in Chemistry in 1993 from the University of Leicester, England, and his DPhil (Oxon) from the University of Oxford in 1997 under the supervision of Allen Hill. His interests in philosophy, history and psychology led to a Magister Artium (MA) degree from the University of Hagen in 1998. He has been a postdoctoral researcher at Harvard Medical School with Bert Vallee and a (senior) lecturer at the University of Exeter before returning to the Saarland in 2005. Claus is an expert in a variety of topics ranging from organic synthesis, bioorganic chemistry, catalytic sensor/effector agents, intracellular diagnostics, nanotechnology, natural products, reactive sulfur and selenium species, and redox regulation via the cellular thiolstat to philosophical, social aspects and environmental aspects of science. He has contributed more than 200 publications in the previously mentioned fields (H-index 61). He is Section Editor-in-Chief in Antioxidants, Section Board Member in Molecules, Editor-in-Chief of Sci and two other journals in the fields of sustainable chemistry and nutrition and is politically active on an ecological democratic platform.

Invited Speakers

Biomedical Sciences, University of Otago, New Zealand

Introduction
Talk
Modulation of Reactive Nitric Oxide in Drug Discovery: Photoresponsive Systems for Precision Control
Bio
Dr Gregory Giles is the Director of Biomedical Sciences at the University of Otago (New Zealand). His research focusses on the therapeutic applications of drugs that modulate levels of reactive oxygen, nitrogen and sulfur species. He has published over 70 scientific articles (~5,000 citations, h-index 31, Google Scholar) and served as an Editor for Current Nutraceuticals and Antioxidants.

Department of Molecular Medicine, Sapienza University of Rome, Italy

Introduction
Talk
Selenotriazines: A Path to Neuroprotection and Treatment of Alzheimer's Disease
Bio
Prof. Cecilia Battistelli is Associate Professor at the Department of Molecular Medicine, Sapienza University of Rome, Italy. Her research interests are focused on molecular mechanisms controlling cell plasticity i.e. cell differentiation, epithelial-to-mesenchymal transition and tumour onset and dissemination, and mediated by extracellular vesicles, non-codingRNAs, epigenetic/epitranscriptomic modifications and RNA-binding proteins. Moreover, she is involved in the validation of different drugs able to modulate gene expression in epithelial to mesenchymal transition, in tumorigenesis and in the onset and development of neurodegenerative diseases (e.g. Alzheimer’s disease). She has co-authored 58 original articles in peer reviewed journals (H-index 25 (Scopus Author ID 55371458900), she is member of Editorial Boards for 4 International scientific Journals, and she served as Guested Editor for 4 special Issues. She is Member of International Societies, and she recently obtained fundings for her Research activity on the role of epigenetics and noncoding genome on tumor development. She has ongoing collaboration with Scientists from different countries and Institutions (University College of London; Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid; Centro De Biología Molecular Severo Ochoa, Madrid; Jagiellonian University, Kraków; Universität des Saarlandes, Saarbrücken, Germany; Bambino Gesù Childrens’ Hospital, Rome). She was recipient of 7 awards from International and National Scientific Societies for her Research.

Postdoctoral researcher at the Institute for Bioorganic Chemistry, School of Pharmacy, Saarland University, Germany

Introduction
Bio
Ahmad Yaman Abdin is a postdoctoral researcher at the Institute for Bioorganic Chemistry, School of Pharmacy, Saarland University, Germany. His work centers on the philosophical, social, and psychological aspects of pharmacy, with a particular focus on drug development, regulation, and application. Yaman has been actively involved in international research, including time at UCCS–Unite de Catalyse et Chimie du Solide, University of Artois, Lille, France. He also volunteered with the National Society for Multiple Sclerosis in the USA. He has presented at and organized several international conferences, and has an H-index of 11. Yaman leads the 'Pharmasophy' group at the Institute for Bioorganic Chemistry.

Webinar Recording

The webinar "Recent Advances in Redox Species” provides an up-to-date insight into current developments, highlights and challenges in the field of biological redox regulation. Cecilia Battistelli discusses the latest developments in the field of Alzheimer’s Research and how selenium-containing drugs may benefit us thanks to their ability to control cellular pathways and, at the same time, modulate the intracellular redox balance. This is followed by a closer look at current NO research, with Gregory Giles enlightening the audience with photoactivated NO donors and an exquisite piece of nanotechnology.

Their talks are followed by an informative panel discussion moderated by Yaman Abdin, which addresses some sticky questions in the field of drug development. These include epistemological questions related to - the limitations of - in vitro assays and the use of models on the one side, and the economic obstacles encountered when moving from a discovery to a licenced drug on the other. Enjoy the webinar!

The webinar was hosted via Zoom and required registration to attend. The full recording can be found below. In order to learn about future webinars, you can sign up to our newsletter by clicking “Subscribe” at the top of the page.

Program

Speaker

Time in CET

Time in CST (Asia)

Prof. Claus Jacob (Chair)

Introduction

9:00 - 9:05 am

4:00 - 4:05 pm

Prof. Gregory Giles

Modulation of Reactive Nitric Oxide in Drug Discovery: Photoresponsive Systems for Precision Control

9:05 - 9:30 am

4:05 - 4:30pm

Q&A Session

9:30 - 9:35 am

4:30 - 4:35 pm

Prof. Cecilia Battistelli

Selenotriazines: A Path to Neuroprotection and Treatment of Alzheimer's Disease

9:35 - 10:00 am

4:35 - 5:00pm

Q&A Session

10:00 - 10:05 am

5:00 - 5:05pm

Dr. Ahmad Yaman Abdin

Panel Discussion

10:05 - 10:30 am

5:05 - 5:30pm

Prof. Claus Jacob (Chair)

Closing of Webinar

10:35 - 10:40 am

5:35 - 5:40pm

Sponsors and Partners

Organizers

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