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Pharmaceutics Webinar | Where Are We Now and Where Is Antimicrobial Therapy Headed?

24 Apr 2024, 10:00 (CEST)

Antimicrobial Agents, Nanoformulations, Novel Therapeutic Strategies, Antimicrobial Resistance, Biofilms, RNA Regulation
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Welcome from the Chair

3rd Pharmaceutics Webinar

Where Are We Now and Where Is Antimicrobial Therapy Headed?

Dear Colleagues,

With much joy and enthusiasm, I welcome each of you to this webinar! As Chair, I am pleased to see the convergence of research aimed at understanding "Where Are We Now and Where Is Antimicrobial Therapy Headed?"

Antimicrobial resistance poses more concerns today than ever before. Our collaborative efforts, insights, and inventions are critical to navigating this difficult world. This meeting provides an opportunity for us to exchange ideas, examine breakthroughs, and plot a course for a future in which effective antimicrobial therapy remains a cornerstone of modern medicine.

Our schedule for this webinar is packed with interesting talks, from antimicrobial dendrimer and lipid nanoparticles to the regulation of biofilms by RNA. I encourage all of you to actively engage in the sessions, contribute your views, and take advantage of the opportunity to network with our panel of experts and other researchers.

Again, welcome to this webinar!

Fábio Fernandes

Date: 24 April 2024 at 10.00 a.m. CEST | 4:00 a.m. EDT | 4:00 p.m. CST Asia
Webinar ID: 841 5162 0647
Webinar Secretariat: journal.webinar@mdpi.com

Webinar Recording

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Event Chair

Institute for Bioengineering and Biosciences (IBB) and Associate Laboratory - Institute for Health and Bioeconomy (i4HB), Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal

Introduction
Bio
Dr. Fábio Fernandes (ORCID 0000-0001-9112-265X) is an Assistant Professor at the Department of Bioengineering of Instituto Superior Técnico (DBE/IST). He is also a member of the Institute for Bioengineering and Biosciences (iBB). He is interested in the production of hybrid vesicles combining different membrane types to achieve added therapeutic functionality. His group has recently focused on the manipulation of extracellular vesicles for therapeutic purposes.

Keynote Speakers

Institute for Bioengineering and Biosciences (IBB) and Associate Laboratory - Institute for Health and Bioeconomy (i4HB), Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal

Introduction
Talk
Introducing the topic “Where Are We Now and Where Is Antimicrobial Therapy Headed?”
Bio
Dr. Sandra Pinto (ORCID 0000-0002-3205-9459) has a PhD in Chemistry. She is an Assistant Researcher at iBB. Her research is mostly focused on medicinal chemistry, biophysics, and microbiology. In the last five years, she has been focused on the development of microscopy methodologies to characterize microbial biofilms and on innovative therapies for drug-resistant infectious diseases. Through this work, she and other collaborators identified core–shell polycationic polyurea dendrimers as new synthetic mimics of antimicrobial peptides (AMPs) with outstanding broad-spectrum antimicrobial activity. These nanoparticles were tolerated well by human cells and showed sub-μM activity against multi-drug-resistant bacteria in their planktonic form. This work recently lead to several oral presentations, publications in high-impact journals, and the publication of national and international patents.

Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal

Introduction
Talk
The Key Role of Liposomes as Delivery Systems for the Management of Infectious Diseases
Bio
Dr Maria Manuela Gaspar (ORCID 0000-0001-6814-7226) completed her PhD in 2005 in Pharmacy, Pharmaceutical Technology at the University of Lisbon, Portugal, and in 2007/2008 completed her post-doctoral studies at Trinity College, University of Dublin, Ireland. She is a Researcher at the Research Institute for Medicines in the Faculty of Pharmacy, Universidade de Lisboa. Her area of research includes the design, characterization, and in vitro evaluation of appropriated delivery systems, of a lipid or polymeric nature, loaded with already commercialized or newly synthesized antibiotics. She is also interested in the establishment of infectious and cancer murine models, such as M. avium, M. tuberculosis, leishmania, MRSA, melanoma, and colon cancer, for validating the therapeutic effect of developed lipid-based systems. She is the co-author of numerous patents, papers in peer-reviewed journals, and book chapters. SCOPUS ID 15834627800 | CIÊNCIA ID 3A10-0732-13F5

Institute for Bioengineering and Biosciences (IBB) and Associate Laboratory - Institute for Health and Bioeconomy (i4HB), Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal

Introduction
Talk
Polyurea Pharmadendrimers: The Next Generation of Antimicrobials
Bio
Dr Vasco Bonifácio (ORCID 0000-0003-2349-8473) is a Professor of Biomaterials and Scientific Coordinator of the Master in Pharmaceutical Technology at IST. He obtained his PhD in Organic Chemistry from FCT-UNL and post-doc in Molecular Electronics from Institüt fur Polymertechnologie (Germany). He was a Visiting Scientist at MIT (USA) and the University of Bordeaux (France). Also, he was a Visiting Professor at Faculdad de Medicina, University Castilla-La Mancha (Spain) and the Fraunhofer Institute for Silicate Research (Germany). Dr Vasco Bonifácio was awarded the Advanced Materials Scientist Medal (2017), the Multiple Myeloma Award (2019), and the RETSCH Scientific Challenge – Enabling progress with ball mils (2024). He was awarded the Outstanding Teaching Award six times at IST. Additionally, he is the President of the Lisbon Delegation of the Portuguese Chemical Society. He is a member of the Editorial Board of Frontiers Nanobiotechnology (Frontiers), QUÍMICA (Portuguese Chemical Society), and is a Guest Editor at MDPI. In 2023, he was listed in the top 2% most cited scientists in the world, a ranking elaborated by the Sandford University. More at www.bonifacio.ws.

Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa (ITQB NOVA), Avenida da República 2780-901, Oeiras, Portugal.

Introduction
Talk
How RNA Regulators Influence Biofilm Formation
Bio
Dr. Vânia Pobre (ORCID 0000-0002-4339-8472) has a PhD in Molecular Biology. She is currently a senior researcher at ITQB NOVA in the Control of Gene Expression Group. During her postdoctoral work, she has dedicated most of her efforts to the field of RNA bioinformatics with a strong focus on transcriptomics and big data analysis. She has applied the advantage of her dual knowledge of being both an experimental and a computational biologist to study the roles of exoribonucleases and small non-coding RNAs in the control of gene expression. She has supervised the work of Masters and PhD students as well as other internships in the lab. She also taught classes in the MolBioS PhD program and in the Medical Microbiology Master programs at ITQB NOVA since 2012. She has also participated in teaching in ERASMUS programs abroad. She also established several national and international collaborations that have allowed her to expand her field of knowledge. In 2021, she was also elected as the representative of the ITQB NOVA biology division for the ITQB/iBET postdoctoral association (PDA). Since 2022 she has also been part of Bioda.pt (Portuguese ELIXIR node).

Program

Speaker/Presentation

Time in CEST

Dr. Fábio Fernandes
Chair Introduction
10:00 am - 10:10 am
Dr. Sandra Pinto
Introducing the topic: “Where Are We Now and Where Is Antimicrobial Therapy Headed?”
10:10 am - 10:30 am
Dr. Maria Manuela Gaspar
The Key Role of Liposomes as Delivery Systems for the Management of Infectious Diseases
10:30 am - 10:50 am
Dr. Vasco Bonifácio
Polyurea Pharmadendrimers: The Next Generation of Antimicrobials
10:50 am - 11:10 am
Dr. Vânia Pobre
How RNA Regulators Influence Biofilm Formation
11:10 am - 11:30 am
Q&A 11:30 am - 12:00 pm
Dr. Fábio Fernandes
Closing of Webinar
12:00 pm - 12:05 pm

Relevant Special Issue

Where Are We Now and Where Is Antimicrobial Therapy Headed?
Guest Editor: Dr. Sandra N. Pinto
Deadline for manuscript submissions: 20 June 2024

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