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Sensors Webinar | Novel Field-Effect Transistor Biosensing

Part of the Sensors Webinar Series series
5 Sep 2022, 12:00 (CEST)

Field Effect Transistor, Electrochemical Sensing, Biomarkers, Biomedical Analysis, Biotechnology, Advanced Nanomaterial
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Welcome from the Chair

6th Sensors Webinar

Novel Field-Effect Transistor Biosensing

I am pleased to welcome you to the webinar for Novel Field-Effect Transistor Biosensing. Field-effect transistor based biosensors are widely applied as advanced biosensing platforms by virtue of their inherent ability to transfer and amplify received biological signals into electrical signals. This webinar aims to serve as a platform to explore recent theoretical and experimental efforts as well as future directions in all types of FET-based biosensors designed for biomolecular detecting. Please relax and enjoy!

Date: 5 September 2022

Time: 12:00 pm CEST | 6:00 am EDT | 6:00 pm CST Asia | 7:00 pm JST

Webinar ID: 814 2373 5799

Webinar Secretariat:


Tianjin Key Laboratory of Molecular Optoelectronic Sciences, Department of Chemistry, School of Science, Tianjin University, China

Shanshan Cheng, received the master degree and Ph.D. degree in engineering both from Waseda University, Japan in 2012 and 2015, respectively. Currently, she is an associate professor in School of Science at Tianjin University. She is working in Tianjin Key Laboratory of Molecular Optoelectronic Science. Her current research interests are electrochemical nanotechnology, organic field effect device and interfaces for biosensing and biomedical applications.

Invited Speakers

Institute of Marine Science and Technology, Shandong University, Tsingdao, China

Graphene, an atom-thick 2D carbon material, was used in biosensing applications because of its excellent physical and chemical properties, such as high intrinsic carrier mobility, direct interaction with molecules, large surface areas, and low intrinsic noise. Together with the FET biosensor advantages of being label-free, fast, sensitive, selective, and low cost and possessing on-site detection and a small sample volume consumption, the graphene-based field-effect transistor (GFET) biosensor has been paid attractive attention for cancer diagnosis and virus screening. Previously, direction immobilization of DNA probes on a GFET channel surface for sensitive nucleic acid detection was reported by our group and others. The limit of detection of 10 fM for miRNAs was achieved; however, it still needs to be improved further to fulfil the actual requirements. To improve the performance of GFET biosensors, channel surface functionalization of GFET becomes crucial. Different strategies were reported to understand the sensing mechanisms and improve the sensing performances, such as Au nanoparticles (AuNPs), 1-pyrenebutyric acid succinimidyl ester (PBASE), and so on. We developed a new multi-functional graphene FET with a PLL-functionalized channel (PGFET) biosensor integrated with a microfluidic structure, in short a PGFET biosensor, for ultrasensitive, specific, rapid detection of breast cancer miRNAs and SARS-CoV-2 RNAs, as shown in Figure 1. This is the first proof of concept of breast cancer miRNA and SARS-CoV-2 RNA detection using a PGFET biosensor, which achieves a detection limit of 1fM within 20 min using 2 μL samples, and wide dynamic detection of five orders magnitudes. The performance enhancement mechanism of PGFET biosensors was studied based on electrical sensing model and experimental results. The detection of breast cancer serum samples and simulated SARS-CoV-2 samples demonstrated their practical application capabilities.
Lin Han received her B.S. in physics from Shandong University, Ji’nan, China in 2003, M.S. in Microelectronics from Tsinghua University, Beijing, China in 2006, and Ph.D. degree in Electrical engineering from Princeton University, NJ, USA in 2011. From 2011 to 2015, she was a postdoc and then promoted to an associated research scientist in Biomedical Engineering at Yale University. From 2015 to 2016, she worked as a principal scientist in Isoplexis company. Since 2016, She has been a Full Professor with the Institute of Marine Science and Technology, Shandong University, Ji’nan, China. Her research interests include biosensors using transistors, SERS, fluorescence, and electrochemical sensing modes, single-cell analysis technologies, flexible electronics, and their applications in human health monitoring, precision diagnosis and therapy of serious diseases, and marine environmental monitoring.

Research Organization for Nano & Life Innovation, Waseda University, Tokyo, Japan

Tetsuya Osaka is a professor in the Department of Applied Chemistry, Faculty of Science and Engineering, Waseda University, Tokyo, Japan, a position he has held since 1986. He currently serves as Director of Institute for Nanoscience and Nanotechnology, Waseda University. His recent work is focused on “electrochemical nanotechnology”, including electro- and electroless-deposition/surface finishing, electronic packaging materials, magnetic storage and energy storage devices, and chemical- and bio-sensors.

Webinar Content

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Time in CEST

Time in CST Asia

Time in JST

Dr. Shanshan Cheng

Chair Introduction

12:00 - 12:10 pm

6:00 - 6:10 pm

7:00 - 7:10 pm

Prof. Dr. Lin Han

The Graphene-Based Field-Effect Transistor (GFET) Biosensor

12:10 - 12:35 pm

6:10 - 6:35 pm

7:10 - 7:35 pm


12:35 - 12:40 pm

6:35 - 6:40 pm

7:35 - 7:40 pm

Prof. Dr. Tetsuya Osaka

R&D on Biosensors by Using Field-Effect Transistor

12:40 - 1:05 pm

6:40 - 7:05 pm

7:40 - 8:05 pm


1:05 - 1:10 pm

7:05 - 7:10 pm

8:05 - 8:10 pm

Closing of Webinar
Dr. Shanshan Cheng

1:10 - 1:15 pm

7:10 - 7:15 pm

8:10 - 8:15 pm

Relevant SI

Novel Field-Effect Transistor Biosensing
Guest Editors: Dr. Congcong Zhang, Prof. Dr. Wenping Hu & Dr. Shanshan Cheng
Deadline for manuscript submissions: 15 November 2022

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