2nd Webinar of Toxics - an Open Access Journal
Chemical Exposures to DNA Damaging Agents, Biological Responses and Impact on Health
This scientific webinar will share and discuss approaches to assess DNA damage induced by genotoxicants in the environment, diet, and endogenously produced electrophiles.
Prof. Dr. Robert J. Turesky, Dr. Jingshu Guo, Prof. Dr. Yinsheng Wang and Prof. Dr. David Phillips will highlight the latest techniques to screen for DNA-damaging and potential cancer-causing agents by targeted and untargeted measurements of their DNA adducts employing mass spectrometry. In conjunction, the biological consequences of DNA adducts, mechanisms of DNA repair in cells, and mutational signatures of environmental agents in humans are reported. These analytical and biological methodologies can help identify hazardous chemicals that contribute to cancer risk.
Date: 24 September 2020
Time: 17:00pm (CEST) | 11:00 am (EDT) | 23:00 pm (CST Asia)
Chair: Prof. Dr. Robert J. Turesky
Webinar ID: 897 6030 3334
The following experts will present and speak:
Prof. Dr. Robert Turesky
Prof. Dr. Robert Turesky holds the Masonic Chair in Cancer Causation and a Professor in the Department of Medicinal Chemistry. His research is devoted to cancer etiology programs at the University of Minnesota. Prof. Turesky received his PhD in nutrition and food science from M.I.T. Prior to his current position, Prof. Turesky served as Group Leader of the Biomarkers Unit, Nestlé Research Center, Lausanne, Switzerland (1986 – 2000); Division Director of Chemistry, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, (2000 – 2004); and Principal Investigator, Wadsworth Center, New York State Department of Health (2004 – 2013). He investigates the biochemical toxicology of dietary and environmental genotoxicants and applies mass spectrometry methods to identify and measure biomarkers of these chemicals in molecular epidemiology studies that seek to understand the role of chemical exposures in the etiology of cancer.
Dr. Jingshu Guo
Dr. Yinsheng Wang
Dr. Yinsheng Wang received his Ph. D. degree from Washington University in St. Louis, after obtaining his BS and MS degrees from Shandong University and Dalian Institute of Chemical Physics, Chinese Academy of Sciences, respectively. Yinsheng’s current research involves the use of mass spectrometry, along with synthetic organic chemistry and molecular biology, for investigation about the occurrence and biological consequences of DNA damage as well as for the identification and functional characterizations of nucleic acid- and nucleotide-binding proteins. Yinsheng has trained, or is in the process of training of, over 70 Ph. D. students and post-doctoral fellows, and he has co-authored ~ 300 research articles. Yinsheng was named as a fellow for the American Association for the Advancement of Sciences in 2012, and he was the recipient for the inaugural Chemical Research in Toxicology Young Investigator Award from the Division of Chemical Toxicology of the American Chemical Society (2012), the 2013 Biemann Medal from the American Society for Mass Spectrometry and the 2018 EAS Award for Outstanding Achievements in Mass Spectrometry.
Dr. David Phillips
The webinar will start at 17:00 pm (CEST) and will last 2 hours.
Speaker & Presentation
Introduction: Prof. Dr. Robert Turesky
17:00 – 17:10
Dr. Jingshu Guo
Mass Spectrometry-Based DNA Adductomics.
17:10 – 17:40
Prof. Dr. Yinsheng Wang
DNA damaging environmental agents, biological consequences, and mechanisms of DNA repair.
17:40 – 18:10
Prof. Dr. David Phillips
Human Mutational Signatures of Environmental Agents.
18:10 – 18:40
Q&A moderated by Prof. Dr. Robert Turesky (Chair)
18:40 – 19:00
This webinar entitled “Chemical Exposures to DNA Damaging Agents, Biological Responses, and Impact on Health” is sponsored by Toxics, an open-access, internationally peer-reviewed journal from MDPI. It was held on Thursday 24 September 2020 and was chaired by Prof. Dr. Robert J. Turesky from University of Minnesota. The journal Toxics publishes research on a wide range of hazardous substances and materials from exposure assessment to mechanisms of toxicity.
Chemical exposures through lifestyle choices, such as smoking, alcohol consumption, diets, and some occupational exposures, are risk factors for developing diseases, including cancer. Environmental and dietary genotoxicants, endogenous electrophiles, and ionizing radiation agents damage the human genome to form DNA adducts. Biomonitoring DNA damage in humans is critical to understand the chemicals involved in mutagenesis and cancer risk. DNA adducts serve as dosimeters for chemical exposure and represent a measure of the biologically effective dose. DNA-adducts also serve as biomarkers to aid in risk assessment and formulating public health policy, exposure reduction, and cancer prevention
The first lecture by Dr. Jingshu Guo from the Turesky Laboratory, at the Masonic Cancer Center, and the Department of Medicinal Chemistry, University of Minnesota, highlights the latest mass spectrometry techniques to screen for DNA-damaging and potential cancer-causing agents employing targeted and untargeted scanning methods. Then, Professor Yinsheng Wang from the Department of Chemistry, University of California, at Riverside, presents technologies to elucidate the biological consequences of DNA adducts, mechanisms of mutagenesis, and the repair of DNA adducts in cells. Thereafter, Professor David Phillips, from the Department of Analytical, Environmental & Forensic Sciences, King's College, London, United Kingdom, presents his group's studies on the mutational signatures of environmental agents characterized by whole genome sequencing in cells and humans.
These complementary analytical and biological methodologies can help identify hazardous chemicals and provide insights into carcinogenic mechanisms and causes of cancer.
The webinar was offered via Zoom, and registration was required for attendance. The full recording can be found below.
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Relevant Special Issues
Special Issues in Toxics
2021: Environmental Pollutants and Their Effects on Host Associated Microbial Communities in Human and Animal Systems
Guest Editors: Dr. Christopher J. Martyniuk, Dr. Joseph H. Bisesi Jr. and Dr. Adamovsky Ondrej
2021: Biomonitoring of Human Exposure: From Individual to Group Exposure Assessment
Guest Editor: Dr. Radu-Corneliu Duca
Accepting submissions until 28 February 2021
2020: Developmental Environmental Exposures, Epigenetics and Long-Term Health
Guest Editor: Dr. Laurie Svoboda
Accepting submissions until 20 December 2020
2020: Molecular Basis of Air-Pollution-Induced Disease Risk
Guest Editors: Prof. Dr. Andrij Holian and Dr. Luke Montrose
Accepting submissions until 30 November 2020
2019: Biomarkers of Environmental Toxicants
Guest Editors: Prof. Dr. Kun LU and Prof. Dr. Robert J. Turesky