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MDPI World Down Syndrome Day Webinar 2024

21 Mar 2024, 16:00 (CET)

Down Syndrome, Chromosome 21, Trisomy 21
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Welcome from the Chair

In order to commemorate World Down Syndrome Day (, MDPI is launching a special webinar to encourage researchers to join together, take action, and raise awareness as to how the exchange of findings facilitates efforts to assist Down Syndrome individuals.

We aim to encourage connection and collaboration among Down Syndrome researchers and the international open access community. Sharing knowledge is a human right, and improving the quality of life of people with Down Syndrome requires the rapid exchange of knowledge across different boundaries.

We are very much looking forward to seeing you at the MDPI World Down Syndrome Day Webinar 2024. Please find below an up-to-date outline of presenters.

Webinar Secretariat

Keynote Speakers

College of Health Solutions, Arizona State University, USA

Dr. Shannon D. R. Ringenbach received her B.Pe. at McMaster University and her Ph.D. at Purdue University and has been an Associate Professor in the College of Health Solutions at Arizona State University for 25 years. She heads the Sensorimotor Development Research Lab, which is currently investigating Assisted Cycle Therapy (ACT) and its effects on motor, cognitive, physical and mental health in a persons with Down syndrome across the lifespan.

Department of Psychiatry, Case Western Reserve University School of Medicine, USA

Dr. Costa received his MD from the State University of Rio de Janeiro, Brazil, and PhD (Biophysics) from the Federal University of Rio de Janeiro. He did his Postdoctoral training at University of Maryland School of Medicine (Pharmacology) and Baylor College of Medicine (Neuroscience). He is Research Professor of Psychiatry at Case Western Reserve University, and recipient of multiple prestigious awards, including the International Sisley-Jerome Lejeune Award. He has dedicated the past 27 years of his academic career to Down syndrome research. His work focuses on translational research in Down syndrome in search for potential pharmacological therapies to enhance cognition and/or prevent the development of Alzheimer-type dementia. His research program has been one of very few in this field to bridge the divide between basic and clinical research. He is the leading proponent of the glutamatergic hypothesis for Down syndrome. During his career, he has held several leadership roles, including the recent lead investigator roles in three clinical trials in which he supervised groups of physicians and psychologists in different hospital settings. He is currently Chair of the Clinical Research Committee for the Trisomy 21 Research Society (T21RS), which is the largest professional society dedicated to Down syndrome research in the world.

Professor with Tenure, Department of Neurosurgery, CU Anschutz Medical Campus, USA

Dr. Granholm-Bentley has a broad background in neurodegenerative disease, especially as it pertains to neurodegeneration and aging. She have been funded by the NIH for more than 30 years and have more than 170 peer-reviewed articles; most of them related to aging and neurodegeneration including Down syndrome (DS). Dr. Granholm-Bentley have an h-index of 62 and have been cited close to 14,000 times. I have more than 30 years of experience working with neurodegenerative disorders. She is currently funded by the NIA to work on tau pathology in individuals with Down Syndrome and Alzheimer’s disease and have focused my recent work on novel biomarkers for neurodegenerative conditions, especially neuron-derived exosome (NDE) biomarkers for DS and DS-AD. Dr. Granholm-Bentley was a founding Chair for the Professional Interest Area (PIA) for DS-AD at the international ISTAART organization, with members from 30 countries. Leading PI for a funded biobank consortium (DSBC) focused on brain donations from persons with DS throughout the lifespan, with 11 sites in the USA and Europe and one in India. The Chair for the Neuropathology work group in the International T21 Research Society (T21RS).

Webinar Recording

The webinar was hosted via Zoom and required registration to attend. The full recording can be found below. In order to learn about future webinars, you can sign up to our newsletter by clicking “Subscribe” at the top of the page.



Time in CET

Time in EDT


04:00pm -04:10pm 11:00am - 11:10am
Dr Shannon Ringenbach
Presentation Theme: Let's Make a PACT (Pediatric Assisted Cycle for Therapy) for Children with Down Syndrome
04:10pm - 04:40pm 11:10am - 11:40am
Prof. Dr. Alberto Costa
Presentation Theme: Thoughts on the Inclusion of Individuals with Down Syndrome in New Clinical Trials of Monoclonal-Antibody-Based Alzheimer's Disease Therapies
04:40pm - 05:10pm 11:40am - 12:10pm
Prof Dr. Ann-Charlotte Granholm-Bentley
Presentation Theme: Neuropathology with Aging in Down Syndrome: Lessons Learned from Mouse Models and Human Brain
05:10pm - 05:40pm 12:10pm - 12:40pm


05:40pm - 05:55pm 12:40pm - 12:55pm

Closing of Webinar

05:55pm - 06:00pm 12:55pm - 01:00pm

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