The present study was conducted to test for in vivo Brine Shrimp Lethality Assay (BSLA) of the Aqueous and ethanolic extracts of Annona reticulata with Allium fistolisum and Brassica oleraceae and correlate cytotoxicity results with known pharmacological activities of the plants. Cytotoxicity was evaluated in terms of LC₅₀ (lethality concentration). Ten nauplii were added into three replicates of each concentration of the plant extract. After 24 hours the surviving brine shrimp larvae were counted and LC₅₀ was assessed. Results showed that the extracts of Annona reticulata with Allium fistolisum and Brassica oleraceae were potent against the brine shrimp when compared alone with combined extracts. It indicated that bioactive components are present in these plants that could be accounted for its pharmacological effects. Thus, the results support the uses of these plant species in traditional medicine.

Abstract:A series of 15 novel derivatives of Synthesis of 2, 4-substituted 1, 5- benzothiazepine 5a–l were synthesized in good yield from the key compound 1, 3-substituted-prop-2-en-1-one (3a-l), called chalcone, with 2-aminothiophenol (0.01mol) and pinch of zirconium oxychloride and solvent dimethyl formamide (DMF), by using ultra-sonication as one of the green chemistry tools. All the synthesised compounds were evaluated for anticonvulsant activity. The synthesized derivatives were investigated for CNS depressant, maximal electroshock seizure (MES), subcutaneous pentylenetetrazole (sc-PTZ) induced seizure and neurotoxicity screening.

New four isomeric chair architectures of 1:1 H-bonded supramolecular complexes were prepared through intermolecular interactions between 4-(2-(pyridin-4-yl)diazenyl-(2-(or 3-)chlorophenyl) 4-alkoxybenzoates and 4-n-alkoxybenzoic acids. The H-bond formation of all complexes was confirmed by differential scanning calorimetry (DSC) and Fourier-transform infrared spectroscopy (FTIR). Mesomorphic characterization was carried by DSC and polarized optical microscopy (POM). It was found that, all prepared laterally choro substituted supramolecular complexes were nematogenic exhibited pure nematic phase and low melting temperature. The thermal stability of the nematic mesophase observed depends upon the location and spatial orientation of the lateral Cl- atom in as well as the length of terminal chains. A comparison between the new investigated 1:1 mixtures and previously reported laterally CH₃ as well as the laterally neat complexes revealed that, the position/orientation and polarity of incorporated lateral group into the azopyridine component enhance the entropy changes and affect on the type and stability of the mesophase. The density functional theory (DFT) theoretical calculations were discussed to predict the molecular conformation for the formed complexes as well as their thermal parameters. The results of the computational calculations revealed that the H-bonded complexes were in a chair form molecular geometry. Moreover, the results explained the effect the position and orientation of the lateral group as well as the alkoxy chain length on the type and the stability of the nematic mesophase. In addition, their impacts on the estimated thermal parameters of H-bonded complex and how these play an important role in influencing thermal and optical properties.

At the request of the author, the paper [1] is retracted. The reason is that it is a repeated submission with 10.3390/ecsoc-23-06621 [2]. MDPI is a member of the Committee on Publication Ethics (COPE) and takes seriously the responsibility to enforce strict ethical policies and standards. The published article [1] is retracted and shall be marked accordingly.

References

1. Shallan, R.N.; Hassan, S.S. Antibacterial and molecular studying of thiourea derivative ligand and its Dimethyl tin(IV) complex with the superior of its Copper(II) complex as a hepatocellular antitumor drug. In Proceedings of the 23rd International Electronic Conference on Synthetic Organic Chemistry, 15 November–15 December 2019; Sciforum Electronic Conference Series, doi: 10.3390/ecsoc-23-06485
2. Salama, M.M.; Shallan, R.N.; Hassan, S.S. Antibacterial and Molecular Study of Thiourea Derivative Ligand and its Dimethyltin(IV) Complex with the Superior of its Copper(II) Complex as a Hepatocellular Antitumor Drug. In Proceedings of the 23rd International Electronic Conference on Synthetic Organic Chemistry, 15 November–15 December 2019; Sciforum Electronic Conference Series, doi: 10.3390/ecsoc-23-06621

At the request of the author, the paper [1] is retracted. The reason is that there is an authorship conflict. MDPI is a member of the Committee on Publication Ethics (COPE) and takes seriously the responsibility to enforce strict ethical policies and standards. The published article [1] is retracted and shall be marked accordingly.

References

1. Khera, N.; Prakash, K. Anthracene-Oxazine based reversible ink. In Proceedings of the 23rd International Electronic Conference on Synthetic Organic Chemistry, 15 November–15 December 2019; Sciforum Electronic Conference Series, doi: 10.3390/ecsoc-23-06457