The 1st International Online Conference on Bioengineering
Bioengineering in a Generative AI World
Part of the 1st International Online Conference on Bioengineering series
16–18 Oct 2024
Bioelectronics, Translational Bioengineering, Biochemical Engineering and Applications, Biomolecular Cellular Tissue Engineering and Applications, Bionics and Biological Cybernetics, Bioprocess and Biosystems Engineering and Applications
- Go to the Sessions
- Event Details
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- Welcome from the Chairs
- Program Overview
- IOCBE 2024 Program (DAY1)
- IOCBE 2024 Program (DAY2)
- IOCBE 2024 Program (DAY3)
- Abstract Book
- Live Session Recordings
- Poster Gallery
- Event Chairs and Committee Members
- Event Speakers
- Sessions
- Instructions for Authors
- Publication Opportunity
- List of Accepted Submissions
- List of Authors
- Event Awards
- Sponsors and Partners
- Conference Secretariat
- Events in series IOCBE2024
It was a successful event, and it’s all because you were a part of it. Thanks for joining in!
Announcements:
We invite all IOCBE 2024 participants to submit research articles to the Special Issue of Bioengineering (ISSN: 2306-5354, Impact Factor: 3.8) with a 20% discount on publication fees. Click here for details.
All accepted abstracts will be included in the IOCBE 2024 conference report, published in Engineering Proceedings (indexed within Scopus, ISSN: 2673-4591).
For extended proceeding paper (4-8 pages), details will be available soon.
Proceedings submission deadline: 2 December 2024
Keep an eye out for more updates and announcements about the event!
Welcome from the Chairs
Dear Colleagues,
In celebration of its tenth anniversary, Bioengineering will host its first International Online Conference on 16-18 October 2024. It is my pleasure to announce and extend this open invitation for you to participate.
With a theme of Bioengineering in a Generative AI World, the conference will feature presentations from distinguished scholars at the nexus of engineering and clinics, engineering and food, engineering and industry, and innovations in bioengineering education. Our conference sessions will following the main sections of our journal with specific attention to:
- Regenerative and Tissue Engineering;
- Biomechanics and Sports Medicine;
- Biomedical Biomaterials;
- Nano-Biotechnology;
- Biosignal Processing;
- Biochemical Engineering.
This conference, organized and hosted by MDPI Bioengineering, will bring together scientists, engineers, and practitioners from different areas to discuss the important recent developments in bioengineering, including bioengineered foods, allotransplantation, multi-omics, theragnostics and bioengineering convergence.
It will represent a great opportunity for the virtual meeting of the interdisciplinary community, aiming to discuss the important breakthroughs in fundamental science undergirding bioengineering, bioengineering technology, and its impact fields in food, industry, environment and animal and human health.
This conference will be a celebration of the contributions of Bioengineering and will feature three awards given for the Best Oral Presentation and Best Poster presented at the conference.
We look forward to your participation.
Kind regards,
Prof. Dr. Anthony Guiseppi-Elie
Founding Editor-in-Chief, Bioengineering
Founding Dean of Engineering, Anderson University SC
President and Sr. Fellow, AIIMSEI
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Program Overview
You can download here the full detailed program with time-zones !
16th October 2024 |
17th October 2024 |
18th October 2024 |
Welcome and Opening Remarks Convening Chair |
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Plenary Talk (09:10 CEST|03:10 EDT|15:10 CST) |
Plenary Talk (09:10 CEST|03:10 EDT|15:10 CST) |
Plenary Talk (09:10 CEST|03:10 EDT|15:10 CST) |
Keynote Talks |
Keynote Talks |
Keynote Talks (09:45 CEST|03:45 EDT|15:45 CST) |
Session 1. Regenerative and Tissue Engineering (Invited and Contributed Oral Presentations) (10:25 CEST|04:25 EDT|16:25 CST) |
Session 3. Biomedical Materials (Invited and Contributed Oral Presentations) (10:25 CEST|04:25 EDT|16:25 CST) |
Session 5. Biosignal Processing (Invited and Contributed Oral Presentations) (10:25 CEST|04:25 EDT|16:25 CST) |
Break (50 min) |
Break Bioengineering Lectureship Award |
Break (50 min) |
Keynote Talks (12:50 CEST|06:50 EDT|18:50 CST) |
Keynote Talks (12:50 CEST|06:50 EDT|18:50 CST) |
Keynote Talks (12:50 CEST|06:50 EDT|18:50 CST) |
Session 2. Biomechanics and Sports Medicine (Invited and Contributed Oral Presentations) (13:30 CEST|07:30 EDT|19:30 CST) |
Session 4. Nano-Biotechnology (Invited and Contributed Oral Presentations) (13:30 CEST|07:30 EDT|19:30 CST) |
Session 6. Biochemical Engineering (Invited and Contributed Oral Presentations) (13:30 CEST|07:30 EDT|19:30 CST) |
Plenary Talk (15:00 CEST|09:00 EDT|21:00 CST) |
Plenary Talk (15:00 CEST|09:00 EDT|21:00 CST) |
Plenary Talk (15:00 CEST|09:00 EDT|21:00 CST) |
Closing Remarks/ Awards Ceremony Convening Chair (15:30 CEST|09:40 EDT|21:40 CST) |
* CEST - Central European Summer Time
EDT - Eastern Daylight Time
CST - China Standard Time
IOCBE 2024 Program (DAY1)
IOCBE 2024 Day 1
Session 1. Regenerative and Tissue Engineering
Date: 16th October 2024 (Wednesday)
Time: 9:00 (CEST, Basel) | 03:00 (EDT, New York) | 15:00 (CST Asia, Beijing)
Time (CEST) |
Speaker | Title |
09:00-09:10 | Prof. Dr. Anthony Guiseppi-Elie Convening Chair |
Welcome and Opening Remarks |
09:10-09:40 |
Prof. Dr. Wai Yee Yeong |
3D Printing and Biofabrication: Progress and Opportunities for Machine Learning in Materials and Processes |
09:40-09:45 | Prof. Dr. Elena Jones (ULeeds, UK) and Prof. Dr. Dimitrios Kouroupis (UMiami, USA) |
Welcome by Session Chairs |
09:45-10:05 | Dr. Dominik Egger (UoH, Germany) Keynote Speaker |
Advanced Cell Culture Technologies for Mesenchymal Stem Cell-Based Therapies |
10:05-10:25 | Dr. Jonathan P. Wojciechowski (Oxford, UK) Keynote Speaker |
Post-printing functionalisation of 3D printed hydrogels as a modular biomaterials platform |
Invited and Contributed Oral Presentations | Session 1: Regenerative and Tissue Engineering | |
10:25-10:40 | Prof. Dr. Gulden Camci-Unal (UMass, Lowell, USA) Invited Speaker |
Unconventional Biomaterials for Tissue Engineering and Regenerative Medicine |
10:40-10:55 | Arwa Alghamdi (ULeeds, UK) Selected Speaker |
Investigating the Role of Insulin-like Growth Factor (IGF) Axis in the Osteogenic Differentiation of Osteoporotic Periodontal Stem Cells |
10:55-11:10 | Nikitha Pandian (Uamity, India) Selected Speaker |
Green Tech in Medicine: Scenedesmus obliquus-reinforced composite Hydrogels for Wound Therapy |
11:10-11:25 | Alexey Dudaev (SFU, Russia) Selected Speaker |
Three-dimensionally Printed Porous Poly(3-Hydroxybutyrate-co-3-Hydroxyvalerate) Scaffold for Bone Regeneration: Fabrication, in Vitro and in Vivo Studies |
11:25-11:40 |
George Skepastianos |
Efficient decellularization of full-thickness abdominal wall scaffold to produce a potential tissue-engineered product |
11:40-11:55 | Marcelo Santos (UFRGS, Brazil) Selected Speaker |
Neural differentiation of mesenchymal cells after 3D bioprinting using a decellularized spinal cord-based biomaterial |
11:55-12:45 | Break |
Session 2. Biomechanics and Sports Medicine
Date: 16th October 2024 (Wednesday)
Time: 12:45 (CEST, Basel) | 06:45 (EDT, New York) | 18:45 (CST Asia, Beijing)
Time (CEST) |
Speaker | Title |
12:45-12:50 | Prof. Dr. Franz Konstantin Fuss (UBT, Germany) Dr. Michael Moreno (TAMU, USA) |
Welcome by Session Chairs |
12:50-13:10 | Prof. Dr. Nicola Hagemeister (ETS, Canada) Keynote Speaker |
Kinematic Assessment of the Knee Joint |
13:10-13:30 | Dr. Rene Ferdinands (USydney, Australia) Keynote Speaker |
Assessing Bowling Legality in Cricket: Biomechanical Insights and Implications |
Invited and Contributed Oral Presentations | Session 2: Biomechanics and Sports Medicine | |
13:30-13:45 | Prof. Dr. Franz Konstantin Fuss (UBT, Germany) Invited Speaker |
Dynamic balance diagnostics with smart insoles |
13:45-14:00 | Dr. Daria Podstawczyk (WUST, Poland) Invited Speaker |
Coaxial 4D Printing of Thermoresponsive Hydrogel Soft Bioactuators with Embedded Perfusable Channels |
14:00-14:15 | Fotios Zisis (UoP-Sparta, Greece) Selected Speaker |
Similar Spatiotemporal Parameters of Gait between Children with Typical Development and Autism Spectrum Disorder |
14:15-14:30 | Nefeli Maria Tsirmpini (UPeloponnese, Greece) Selected Speaker |
Quantitative data to evaluate Clinical Pilates efficacy in chronic low back pain using inertial measurement units |
14:30-14:45 | David Perpetuini (Ud’A, Italy) Selected Speaker |
Impact of Box Squats and Pin Squats on Powerlifting Performance: An Electromyographic Analysis |
14:45-15:00 | Dr. Andrew Robbins (UTTyler, USA) and Dr. Michael Moreno (TAMU, USA) Invited Speakers |
Learning how Sheep Move: Developing a General Inverse Kinetic Model for Sheep |
15:00-15:30 | Prof. Dr. Kristala L. Jones Prather (MIT, USA) Plenary Speaker |
Biosensor-Guided Regulation of Metabolic Pathways |
IOCBE 2024 Program (DAY2)
IOCBE 2024 Day 2
Session 3. Biomedical Materials
Date: 17th October 2024 (Thursday)
Time: 9:00 (CEST, Basel) | 03:00 (EDT, New York) | 15:00 (CST Asia, Beijing)
Time (CEST) |
Speaker | Title |
09:10-09:40 |
Prof. Dr. Chuanbin Mao |
Phage-Based Biomaterials, Nanomedicine and Regenerative Medicine |
09:40-09:45 | Prof. Dr. Gary Bowlin (UMemphis, USA) and Prof. Dr. Archana Bhaw-Luximon (UM, Mauritius) |
Welcome by Session Chairs |
09:45-10:05 | Prof. Dr. Archana Bhaw-Luximon (UM, Mauritius) Keynote Speaker |
Biomaterials addressing health and climate change challenges |
10:05-10:25 | Prof. Dr. Gary L. Bowlin (UMemphis, USA) Keynote Speaker |
Near-field Electrospinning Use in Fabricating the Next-generation Vascular Grafts |
Invited and Contributed Oral Presentations | Session 3: Biomedical Materials | |
10:25-10:40 | Prof Dr Seda Kizilel (KoçU, Turkey) Invited Speaker |
Designing Immunologically Invisible Spheroids Using Biomaterials, Genetic Engineering and Machine Learning |
10:40-10:55 | Amina Voznyuk (MISIS, Russia) Selected Speaker |
Layer-by-layer assembly for manufacturing local chemotherapy platforms with controlled and sustained drug release to prevent local tumor relapse |
10:55-11:10 | Bani Preet Kaur (Uamity, India) Selected Speaker |
The Role of Zinc Metal–Organic Framework (Zn-MOF) in Augmenting Anti-Mycobacterial Drug Action |
11:10-11:25 | Sanjesh Kumar (RBCoP, India) Selected Speaker |
NeuroAmph: Innovative Synergy of Polydopamine and Peptide Amphiphiles for Enhanced Cognitive Pathology Treatment |
11:25-11:40 |
Elizaveta Sergeevna Permyakova |
Superabsorbent Curdlan–Chitosan Foams with Bioactive Additives for Healing Wounds |
11:40-11:55 | Elisa Roldan Ciudad (MMU, UK) Selected Speaker |
Combining machine learning and musculoskeletal models: A novel route to optimise the manufacturing of biomimetic ligament implants. |
11:55-12:25 | Break |
Session 4. Nano-Biotechnology
Date: 17th October 2024 (Thursday)
Time: 12:25 (CEST, Basel) | 06:25 (EDT, New York) | 18:25 (CST Asia, Beijing)
Time (CEST) |
Speaker | Title |
12:25-12:45 |
Dr. Gianluca Di Flumeri |
Bioengineering Lectureship Award New frontiers for assessing Human Factor: a bioengineering challenge |
12:45-12:50 | Dr. Gary Chinga Carrasco (RISE PFI, Norway) |
Welcome by Session Chairs |
12:50-13:10 | Prof. Dr. Pedro Fardim (KULeuven, Belgium) Keynote Speaker |
Biopolymers and Bio-hybrids for Health and Care |
13:10-13:30 | Prof. Dr. Anthony Guiseppi-Elie (TAMU, USA) Keynote Speaker |
Modeling a Multi-modal Biochip for Physiological Status Monitoring in the Triage of Hemorrhagic Trauma and for Allograft Stratification |
Invited and Contributed Oral Presentations | Session 4: Nano-Biotechnology | |
13:30-13:45 | Dr. Hana Lísalová (FZU-CAS, Czech Republic) Invited Speaker |
Advancing Cell-on-a-Chip Interfaces with Bio-functional Terpolymer Nano-Brushes Exhibiting Strong Resistance to Bacteria |
13:45-14:00 | Dr. Eduardo Espinosa (UCordoba, Spain) Invited Speaker |
Biopolymers and 3D Bioprinting |
14:00-14:15 | Rupal Kaushik (IIT, India) Selected Speaker |
Biocompatible Surface-Modified MoS2 Nanoflowers for Antibacterial Applications: Unravelling the Mechanistic Insights |
14:15-14:30 | Etelka Chung (UH, UK) Selected Speaker |
Development of antimicrobial PDMS polymers containing Silver-Copper Nanoparticles for potential applications in biomedical devices |
14:30-14:45 | Lyubomira Radeva (MUS, Bulgaria) Selected Speaker |
The encapsulation of oregano oil in natural nanogels and preliminary studies on its antiviral activity |
14:45-15:00 | Shichao Ding (UCSanDiego, USA) Invited Speakers |
Rational Design of Single-Atom Nanozymes for Biomedical Applications |
15:00-15:30 | Prof. Dr. Luke P. Lee (Harvard, USA) Plenary Speaker |
Nanomedicine via Quantum Plasmonic SANDs, EXODUS, and Brain Organoid MAP |
IOCBE 2024 Program (DAY3)
IOCBE 2024 Day 3
Session 5. Biosignal Processing
Date: 18th October 2024 (Friday)
Time: 9:00 (CEST, Basel) | 03:00 (EDT, New York) | 15:00 (CST Asia, Beijing)
Time (CEST) |
Speaker | Title |
09:10-09:40 |
Prof. Dr. Tingrui Pan |
The Rise of Flexible Iontronics for Medical Intelligence |
09:40-09:45 | Prof. Dr. Andrea Cataldo (USalento, Italy) and Prof. Dr. Egidio De Benedetto (UNaples Federico II, Italy) |
Welcome by Session Chairs |
09:45-10:05 | Prof. Dr. Selim Bozkurt (UU, UK) Keynote Speaker |
Detection of Cardiovascular Disorders in Patients Supported with Continuous-Flow Left Ventricular Assist Devices by Monitoring Electrical Current Signals |
10:05-10:25 | Prof. Dr. Leopoldo Angrisani (UNFII, Italy) Keynote Speaker |
Biosignal-based human-machine interfaces: a metrological approach to performance characterization |
Invited and Contributed Oral Presentations |
Session 5: Biosignal Processing |
|
10:25-10:40 | Daniela Pedrozo Roca (INIBIO, UNSJ, Argentina) Invited Speaker |
Functional Characterization of Brain Areas Using Functional Magnetic Resonance Imaging |
10:40-10:55 | Martim G. Silva (UCP, Portugal) Selected Speaker |
Speech Non-Linear Multiband-Time-Series Analysis for Detecting Alzheimer’s Disease |
10:55-11:10 | Anton Gerasimov (NSTU, Russia) Selected Speaker |
Effect of Individual Abilities for Mental 3D Rotation in Learning EEG-Controlled BCIs" |
11:10-11:25 | Mariano Jose Guillen (NUT-FACET, Argentina) Selected Speaker |
Exploratory simulation study on high-frequency detection of cell internal structures |
11:25-11:40 |
Svitlana Tymetska |
Poly(vinyl pyridine) coatings cross-linked with Cu or Zn as active layers for biosensors that are sensitive to protein adsorption and cell adhesion |
11:40-11:55 | Joana Pinto (UPT, Portugal) Selected Speaker |
Mapping Decision-Making Traits through EEG-Derived Personality Profiles |
11:55-12:45 | Break |
Session 6. Biochemical Engineering
Date: 18th October 2024 (Friday)
Time: 12:45 (CEST, Basel) | 06:45 (EDT, New York) | 18:45 (CST Asia, Beijing)
Time (CEST) |
Speaker | Title |
12:45-12:50 | Prof. Dr. Liang Luo (HUST, China) |
Welcome by Session Chairs |
12:50-13:10 | Prof. Dr. Carmen C. Mayorga Martinez (UPC, Peru) Keynote Speaker |
Functional Materials to Obtain Smart Microrobotics for Diagnostics and Therapy |
13:10-13:30 | Prof. Dr. Maria Teresa Fernandez Abedul (UOviedo, Spain) Keynote Speaker |
Development of bioelectrochemical platforms for decentralized and low-cost analysis of molecules of interest in clinical, food or environmental fields |
Invited and Contributed Oral Presentations | Session 6: Biochemical Engineering | |
13:30-13:45 | Prof. Dr. Silviya Petrova Zustiak (SLU, USA) Invited Speaker |
Development of Super-Lubricious Hydrogel Microspheres for the Treatment of Knee Osteoarthritis |
13:45-14:00 | Stephanie Klinghammer (TUD, Germany) Selected Speaker |
Development of intraoral sensors for the continuous measurement of clinically relevant parameters in the oral cavity |
14:00-14:15 | Hakan Çelebi (AU, Turkey) Selected Speaker |
Current perspectives on the applicability of lignin material in the biosorption process |
14:15-14:30 | Carla Goy (NUT-FACET, Argentina) Selected Speaker |
Alternative methods for low-cost microfluidic device fabrication |
14:30-14:45 | Harshavardhan Reddy Borra (YVU, Inadia) Invited Speakers |
Enhancing biomanufacturing efficiency: A model-based plug-and-play Hybrid fed-batch process using ATF perfusion for high-yield drug substance production |
14:45-15:00 | Antonio D’Ambrosio (UCBM, Italy) Selected Speaker |
Prediction of drug transport, distribution, and absorption by a multicompartmental physiologically based pharmacokinetic model |
15:00-15:30 | Prof. Dr. Molly Shoichet (UToronto, Canada) Plenary Speaker |
Overcoming Barriers: Local Cell & Therapeutic Delivery to the Central Nervous System |
15:30-15:40 | Prof. Dr. Anthony Guiseppi-Elie Convening Chair |
Closing Remarks/ Awards Ceremony |
Abstract Book
Live Session Recordings
Event Chairs
Founding Editor-in-Chief, Bioengineering,
Founding Dean of Engineering, Anderson University SC,
President and Sr. Fellow, AIIMSEI
Prof. Dr. Anthony Guiseppi-Elie is an international medical sciences, engineering, and innovation consultant at the American International Institute of Medical Sciences, Engineering, and Innovation. A former Vice President and Chief Academic Officer at Tri-County Technical College. He has 15 years of industrial research and product development experience and 18 years of experience as a tenured, titled, and endowed full professor at universities that include Virginia Commonwealth University, Clemson University, Texas A&M University, and Anderson University, where he was the Founding Dean of the College of Engineering. He has been associated with three startup companies and is Founder, President, and Scientific Director of ABTECH Scientific, Inc. A US citizen who was born in Trinidad and Tobago, he holds the Sc.D. in Materials Science and Engineering from MIT, the M.Sc. in Chemical Engineering from the University of Manchester (UMIST), and the B.Sc. (First Class Honors) in Applied, Analytical, and Biochemistry from the University of the West Indies (UWI). He has published over 225 peer-reviewed journal articles, holds 8 patents, and is a fellow of IEEE, AIMBE, BMES and the RSC. His research interests are in physiological monitoring during hemorrhagic trauma and allotransplantation, polymeric nanobiomaterials in drug delivery and tissue regeneration, and microanalytical systems in the service of human health and medicine.
Media and Interfaces Laboratory (LAMEIN), Bioengineering Department, Faculty of Exact Sciences and Technology (FACET), National University of Tucumán, Superior Biological Research Institute (INSIBIO), CONICET, Argentina
Rossana Madrid is EE and Ph.D. in Bioengineering. She is currently a Full Professor of Biomedical Transducers and Biosensors and Microsystems in the Biomedical Engineering Program, and also at a Doctoral degree, from the Faculty of Exact Sciences and Technology at the University of Tucumán, Argentina. She is Principal Researcher at the National Council of Scientific and Technical Research of Argentina (CONICET) and she leads the Biosensors and Microsystems group. She has published R&D papers in national and international journals, two book chapters, and has developed four patents. She leads research grants and international cooperation grants with German Universities. Her main research fields include sensors and biosensors, microfluidic systems, and paper-based POC devices for biomedical and environmental applications.
Session Chairs
Dr. Elena A. Jones
Leeds Institute of Molecular Medicine, School of Medicine, University of Leeds, Leeds, UK
Prof. Dr. Gary L. Bowlin
Department of Biomedical Engineering, The University of Memphis, Memphis, USA
Prof. Dr. Franz Konstantin Fuss
1. Chair of Biomechanics, Faculty of Engineering Science, University of Bayreuth, Bayreuth, Germany 2. Division of Biomechanics, Department of Biomechatronic Systems, Fraunhofer Institute of Manufacturing Engineering and Automation IPA, Stuttgart, Germany
Prof. Dr. Michael Moreno
Department of Mechanical Engineering, J. Mike Walker ’66 Faculty, Texas A&M University, Texas, USA.
Dr. Gary Chinga Carrasco
RISE PFI, Høgskoleringen 6b, Trondheim, Norway
Dr. Andrea Cataldo
Department of Innovation Engineering (DII), University of Salento, Lecce, Italy
Prof. Dr. Liang Luo
College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China
Dr. Dimitrios Kouroupis
Department of Orthopaedics, Miller School of Medicine. University of Miami, Miami, USA.
Dr. Egidio De Benedetto
Department of Information Technology and Electrical Engineering, University of Naples Federico II, Naples, Italy.
Event Committee Members
Department of Mechanical Engineering, National Chung-Hsing University, Taichung, Taiwan.
Nanotechnology Innovation Center Kansas State (NICKS), Kansas State University, Manhattan, USA.
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Center for Surgical Bioengineering, University of California Davis, CA, USA.
School of Materials Science and Engineering, Nanyang Technological University, Singapore City, Singapore.
School of Mechanical & Manufacturing Engineering, Dublin City University, Dublin, Ireland.
Department of Cardiothoracic Surgery, Stanford University School of Medicine, California, USA.
Faculty of Engineering, University Campus Biomedico of Rome, Rome, Italy
Department of Bioscience Research, Department of Medicine, Department of Microbiology, Immunology and Biochemistry, The University of Tennessee Health Science Center, Memphis, TN, USA
Biotechnology Institute for Cell and Tissue Culture Technologies, University of Natural Resources and Life Sciences Vienna, Vienna, Austria
Department of Mechanical Engineering and Engineering Science, University of North Carolina at Charlotte, Charlotte, NC, USA.
Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, USA
Irma Lerma Rangel School of Pharmacy, Texas A&M Health Science Center, Texas A&M University, College Station, TX , USA.
Centre for Advanced Biomedical Imaging (CABI), Department of Medicine, University College London, London, UK.
Department of Innovative Technologies in Medicine & Dentistry, "G. D'Annunzio" University of Chieti–Pescara, Italy.
Human Histology & Embryology Section, Department of Surgery, Dentistry, Paediatrics & Gynaecology, University of Verona Medical School, Verona, Italy.
Department of Biological Sciences, Oakland University, Rochester, USA.
Stem Cell Core, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, USA.
Department of Mechanical Engineering, University of Kansas, Lawrence, USA.
School of Life Science and Biotechnology, Dalian University of Technology, Dalian, China.
Department of Biomedical Engineering, College of Engineering, University of Miami, Coral Gables, FL, USA.
Physics department, Faculty of Science, University of Lisbon, Lisbon, Portugal.
School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, Loughborough, UK.
The Mucosal Immunology & Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
Department of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk, Republic of Korea.
Department of Rehabilitation Medicine, Tongji University School of Medicine, Shanghai, China.
NOVA Medical School, Faculty of Medical Sciences, New University of Lisbon, Lisbon, Portugal.
Department of Bioengineering, Faculty of Engineering, Ege University, Izmir, Turkey.
Department of Information Engineering, Marche Polytechnic University, Ancona, Italy.
Department of Information Engineering, Marche Polytechnic University, Ancona, Italy.
Department of Chemistry, The Hong Kong University of Science and Technology, HKSAR, Pokfulam, Hong Kong.
Department of Electrical and Information Engineering (DEI), Polytechnic University of Bari, Bari, Italy.
Plenary Speakers
Harvard Medical School, Harvard University, Brigham and Women's Hospital, Boston, USA.,
[13:00 Coordinated Universal Time (UTC) | 17 Oct 2024 (Thursday)]
Nanomedicine via Quantum Plasmonic SANDs, EXODUS, and Brain Organoid MAP. Abstract: In this presentation, I will report on the importance of human exosomes in both diagnostics and therapeutics. First, I will report the advancements in applications of the EXODUS (EXOsome Detection via the Ultrafast-purification System) for the quick, pure, and automated label-free purification of exosomes from various biofluids. We have made significant progress in purifying exosomes from cancer patients' urine samples, facilitating efficient multiomics analysis. Additionally, our iTEARS (integrated Tear Exosome Analysis via Rapid-isolation System) identifies protein and RNA biomarkers, enabling predictive, preventive, personalized diagnosis of various diseases by analyzing a teardrop. I will also discuss the development of a patient-derived brain organoid MAP (Microphysiological Analysis Platforms) using iPSCs to form brain organoids to simultaneously detect and deliver EVs (extracellular vesicles) and EBs (electrophysiological brainwaves) from brain organoids. We aim to understand the connection between molecular and neurophysiological expressions and discover efficient biomarkers. Through in vitro models of the human brain MAP, we strive to address fundamental questions of neuropathogenesis, find solutions for neurodegenerative diseases, and explore potential therapeutic options for precision medicine by systematically studying the dynamics of EVs and EBs. Our collaborative efforts to create EXODUS, iTEARS, and brain organoid MAPs are paving the way for the 4Ps (predictive, preventive, personalized, participative) of precision medicine.
Luke P. Lee is a Professor at Harvard Medical School. He received his BA and PhD in from UC Berkeley. He joined the faculty at UC Berkeley in 1999 after more than a decade of industry experience. He became the Arnold and Barbara Silverman Distinguished Professor and the Lester John and Lynne Dewar Lloyd Distinguished Professor at Berkeley. He also served as the Chair Professor in Systems Nanobiology at ETH Zürich. He founded the Biomedical Institute for Global Healthcare Research & Technology (BIGHEART). He served as Associate President for International Research and Innovation and Tan Chin Tuan Centennial Professor at the National University of Singapore. He also founded the Institute for Quantum Biophysics at Sungkyunkwan University, Korea. He has authored over 350 research articles, contributed to four book chapters, and holds 60 international patents. He has been honored as a Fellow of the Royal Society of Chemistry and the American Institute of Medical and Biological Engineering. He has received numerous awards, including the IEEE William J. Morlock Award, NSF Career Award, Fulbright Scholar Award, and the HoAm Prize.
Institute of Biomedical Engineering, University of Toronto, Toronto, Canada.,
[13:00 Coordinated Universal Time (UTC) | 18 Oct 2024 (Friday)]
Overcoming Barriers: Local Cell & Therapeutic Delivery to the Central Nervous System. Abstract: We are particularly interested in regeneration in the central nervous system after traumatic injury or disease such as spinal cord injury, stroke and blindness. After traumatic injury to the central nervous system, a glial scar forms which limits both degeneration and regeneration. To promote the latter, we (and others) have been investigating chondroitinase ABC; however, the impact of this potent enzyme has been limited by its delivery and its inherent instability. We invented an affinity-release system and a more stable, mutated chondroitinase ABC, which we have been investigating in the context of spinal cord injury and stroke. For stroke, we have also been interested in endogenous stem cell stimulation, which we have been pursuing in collaboration with Cindi Morshead’s laboratory. With local delivery, we are able to release factors directly to the brain to modulate the immune system, stimulate tissue repair and functional recovery. In blindness due to age-related macular degeneration, the cells at the back of the eye - the photoreceptors and the retinal pigmented epithelium - die. In order to stop and reverse blindness, these cells need to be replaced, yet finding a source of these cells is in itself difficult. In collaboration with Prof Derek van der Kooy’s lab, we investigated the co-transplantation of both photoreceptors and retinal pigmented epithelium using an injectable hydrogel, which has shown to enhance cell survival, leading to some functional repair. Fascinatingly, this hydrogel impacts the recently discovered phenomenon of material transfer, which we are pursuing in collaboration with Valerie Wallace’s lab. While mouse photoreceptors were known to transfer material, it wasn’t until our recent study that we realized that human photoreceptors can also transfer material, opening up new possibilities for stem cell transplantation.
Professor Molly Shoichet is University Professor, a distinction held by less than 2% of the faculty, at the University of Toronto. She served as Ontario’s first Chief Scientist in 2018 where she worked to enhance the culture of science. Dr. Shoichet has published over 800 papers, patents and abstracts and has given over 580 lectures worldwide. She currently leads a laboratory of 30 and has graduated 260 researchers. Her research is focused on drug and cell delivery strategies in the central nervous system (brain, spinal cord, retina) and 3D hydrogel culture systems to model cancer. Dr. Shoichet co-founded four spin-off companies, is actively engaged in translational research and science outreach. Dr. Shoichet is the recipient of many prestigious distinctions and the first person to be inducted into all three of Canada’s National Academies of Science of the Royal Society of Canada, Engineering and Health Sciences. In 2018, Professor Shoichet was inducted as an Officer of the Order of Canada and in 2011, she was awarded the Order of Ontario. Dr. Shoichet was the L’Oreal-UNESCO For Women in Science Laureate for North America in 2015, elected Foreign Member of the US National Academy of Engineering in 2016, won the Killam Prize in Engineering in 2017 and elected Fellow to the Royal Society (UK) in 2019. In 2020, Dr. Shoichet was awarded the NSERC Herzberg Gold Medal and won the Margolese National Brain Disorders Prize. In 2022, Dr. Shoichet was elected Fellow of the US National Academy of Inventors. Dr. Shoichet received her SB from the Massachusetts Institute of Technology (1987) and her PhD from the University of Massachusetts, Amherst in Polymer Science and Engineering (1992).
School of Mechanical & Aerospace Engineering, Nanyang Technological University, Singapore.,
[7:10 Coordinated Universal Time (UTC) | 16 Oct 2024 (Wednesday)]
3D Printing and Biofabrication: Progress and Opportunities for Machine Learning in Materials and Processes. Abstract: In recent years, machine learning (ML) technologies have been widely adopted to explore complex relationships among various parameters in different 3D printing techniques and biofabrication processes . These ML models are adept at identifying intricate patterns from large, well-organized datasets, thereby revealing hidden insights crucial for making informed decisions during the 3D printing process. The collaborative integration of ML and 3D Printing has the potential to transform the design and production of biotechnology parts. This talk discusses the challenges and opportunities arising at the intersection of these two dynamic fields.
Professor Yeong is Professor of Mechanical Engineering in the School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore. Professor Yeong’s research work focuses on 3D bioprinting, as well as 3D printing of functional materials. She has attracted more than SGD$15M in research grants and published more than 180 papers. She has been recognized with multiple awards including Top 50 Asia Women Tech Leaders 2024, NRF Investigatorship Class of 2022, Singapore 100 Women in Tech (SG100WIT) 2021 and the Inaugural TCT Woman in 3D Printing Award 2019. She is listed in the Top 2% Scientists Worldwide in a study from Stanford University since 2021, and named Clarivate Highly Cited Researcher 2022.
Head of the Department of Chemical Engineering, Massachusetts Institute of Technology (MIT), Cambridge, USA.,
[13:00 Coordinated Universal Time (UTC) | 16 Oct 2024 (Wednesday)]
Biosensor-Guided Regulation of Metabolic Pathways. Abstract: Microbial systems offer the opportunity to produce a wide variety of chemical compounds in a sustainable fashion. Economical production, however, requires processes that operate with high titer, productivity, and yield – and that, preferably, minimize the number of material inputs to the system. Transcription factor-based biosensors provide an opportunity to utilize existing substrates as inducers for pathway genes. The specificity of these biosensors also enables “switch-like” behavior, in which certain pathways can be activated only in the presence of their associated substrates. We have leveraged previous work in autonomous regulation of metabolic pathways to establish a paradigm for substrate-mediated activation of biosynthetic pathways. This approach is particularly interesting in the context of mixed substrate feeds with variable composition. I will discuss our group’s efforts to build, characterize, and deploy biosensors for substrate-regulated control of biosynthesis.
Prof. Dr. Kristala L.J. Prather is the Arthur D. Little Professor and Department Head in the Department of Chemical Engineering at MIT. She received an S.B. degree from MIT in 1994 and Ph.D. from the University of California, Berkeley (1999), and worked 4 years in BioProcess Research and Development at the Merck Research Labs prior to joining the faculty of MIT. Her research interests are centered on the design and assembly of recombinant microorganisms for the production of small molecules, with additional efforts in novel bioprocess design approaches. Prather’s honors include the Charles Thom Award of the Society for Industrial Microbiology and Biotechnology (2017), the Andreas Acrivos Award for Professional Progress in Chemical Engineering of the American Institute of Chemical Engineers (AIChE, 2021), and the Marvin J. Johnson Award (BIOT Division, American Chemical Society, 2024). Additional honors include selection as a Fellow of the Radcliffe Institute for Advanced Study (2014-2015), the American Association for the Advancement of Science (AAAS; 2018), the American Institute for Medical and Biological Engineering (AIMBE; 2020), and AIChE (2020).
Department of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong.,
[7:10 Coordinated Universal Time (UTC) | 17 Oct 2024 (Thursday)]
Phage-Based Biomaterials, Nanomedicine and Regenerative Medicine. Abstract: Bacteriophages, also called phages, are human-safe non-toxic viruses that specifically infect bacteria. They are one of the most common and diverse entities in biospheres. They can be pictured as nanobiomaterials assembled from proteins and nucleic acids. For example, filamentous phage (such as M13 phage) is a nanofiber (about 1 nm long and 7 nm wide) with multiple genetically modifiable proteins constituting a capsid and a DNA as a core inside the capsid. Since the DNA inside the phages encodes the proteins on the capsid, phages can be genetically engineered to bear the capability of targeting proteins, cells, tissues, and organs. Therefore, they are ideal for many applications in precision nanomedicine and regenerative medicine. This talk will summarize my group’s recent studies on the use of phages in these areas, including ultrasensitive biomarker detection for disease diagnosis, targeted drug delivery, directed stem cell differentiation, accelerated tissue formation, and nano-therapeutics for targeted disease treatment.
Chuanbin Mao is currently a Global STEM Professor at the Department of Biomedical Engineering of the Chinese University of Hong Kong and the director of Jockey Club STEM Lab of Nature-Inspired Precision Medical Engineering. He has been elected as a fellow of prestigious professional societies, including the American Association for the Advancement of Science (AAAS), American Academy of Microbiology (AAM), American Chemical Society (ACS), ACS Division of Polymeric Materials Science & Engineering (PMSE), American Institute for Medical and Biological Engineering (AIMBE), Biomedical Engineering Society (BMES), International Academy of Medical & Biological Engineering (IAMBE), and Royal Society of Chemistry (RSC). He is a recipient of multiple awards, including the US National Science Foundation (NSF) CAREER Award. He has published over 300 peer-reviewed articles in highly ranked journals such as Chemical Reviews, Science, Nature Materials, Nature Nanotechnology, Nature Communications, Advanced Materials, and Angewandte Chemie. His current research is focused mainly on phage bioengineering, biomaterials, biosensors, nanobiotechnology, nanomedicine, and regenerative medicine. [06/2024: h-index-80, 21877 citations]
Suzhou Institute for Advanced Research, University of Science and Technology of China, Suzhou, China.,
[7:10 Coordinated Universal Time (UTC) | 18 Oct 2024 (Friday)]
The Rise of Flexible Iontronics for Medical Intelligence. Abstract: The rise of flexible iontronics has provided unconventional yet inspiring alternatives to existing medical challenges in recent years. The emerging technology has illustrated its potential to achieve high-sensitivity high-precision biomechanical and biofluidic measurements in intimate contact with human epidermal surfaces, onto which can be easily attached, such as skin, hearts, blood vessels, eyes, joints and muscles. Real-time monitoring and feedback of biomechanical variations of human vitals can provide invaluable diagnostic and prognostic information over the cardiovascular, respiratory, and neuromuscular systems. Therefore, it has become a transformative initiative to improve both the accuracy and efficacy of future patient-centered medicine. Before the power of the emerging flexible iontronics can be fully revealed for medical purposes, several key technological challenges need to be addressed, including high-quality acquisition of biomechanical signals, high reliability and stability of bio-interface, as well as undisturbed patient-friendly measurement schemes. In this talk, the flexible iontronic sensing (FITS) mechanism, as the next-generation tactile sensing modality, will be introduced to tackle the aforementioned challenges, which offers the highest mechanical-to-capacitive sensitivity among all the tactile sensors, at least three orders of magnitude greater than that of the conventional counterparts, in addition to its ultrahigh signal-to-noise ratio and anti-interference performance. Another unique feature of iontronic sensing is the ubiquitous presence of ionic carriers in almost all natural surfaces, including human skin, which can be potentially unified into the device structure, leading to an extremely simplified hybrid architecture with the bio-interface seamlessly integrated...(click for more)
Professor Pan Tingrui is a Fellow of the American Institute for Medical and Biological Engineering (AIMBE) and the Royal Society of Chemistry (RSC). He is currently a Yangtze River Chair Professor of the University of Science and Technology of China and directs the Institute for Innovative Medical Devices (iMED). Before joining USTC, Professor Pan was a tenured Full Professor at UC Davis, where he initiated Global Research Experience in Advanced Technologies (GREAT) Program and directed Center for Nano and Micro-Manufacturing (CNM²). He is currently an Associate Editor of Annals of Biomedical Engineering (TBME) and Journal of Medical Devices (JMD) and serves on the editorial board of Bioengineering and Journal of Chinese Medicine. His research interests span a wide range of bioengineering frontiers, including iontronic sensing, tactile intelligence, medical wearables, microfluidic interfaces and laboratory intelligence. His group has authored over 100 referenced publications on high impact journals and has been granted more than 20 international patents. Notably, Professor Pan is well known for his invention of the world-first flexible iontronic sensor (FITS), as the latest generation of tactile sensing technology, and has successfully translated it from a laboratory prototype to a series of industrial and medical products. For his contribution to both academic innovation and technology translation, Professor Pan has received a number of international awards and domestic recognitions, including the National Science Foundation (NSF) Early Career Development (CAREER) Award and Emerging Frontiers in Research and Innovation (EFRI) Award, Xerox Award, CES Innovation Award, UC Davis Outstanding Service Award, Outstanding Early-Career Engineering Faculty Award, and the First Prize of China Innovation and Entrepreneurship Competition.
Keynote Speakers
Faculty of Natural Sciences, Leibniz Universität Hannover, Hannover, Germany.
Presentation Title: Advanced Cell Culture Technologies for Mesenchymal Stem Cell-Based Therapies (Session 1: Regenerative and Tissue Engineering )
Dominik Egger has been appointed as a professor at Leibniz University. After completing his studies in Life Sciences at Leibniz Universität Hannover, Mr Egger conducted research as part of his doctorate at the Department of Biotechnology at the University of Natural Resources and Life Sciences Vienna in Austria. He completed his doctorate there in 2017 on the topic of " Concepts for the implementation of physiologic conditions for the cultivation of human mesenchymal stem cells". During his postdoctoral phase, he developed methods for the non-invasive monitoring of 3D cell culture processes as well as isolation and expansion processes for mesenchymal stem cells in 3D cell culture and bioreactor systems. This was followed by teaching activities at the University of Zaragoza, Spain, and his nomination as Deputy Head of Institute at the University of Natural Resources and Life Sciences, Vienna.
Stevens Group, Kavli Institute for Nanoscience Discovery, Oxford, UK,
Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
Presentation Title: Post-printing functionalisation of 3D printed hydrogels as a modular biomaterials platform (Session 1: Regenerative and Tissue Engineering )
Dr. Jonathan P. Wojciechowski is a Senior Researcher and Theme Leader in the research group of Professor Dame Molly Stevens at the University of Oxford. He completed his PhD in Chemistry at the University of New South Wales (2018) under the supervision of Professor Pall Thordarson and was previously a postdoctoral researcher at Imperial College London (2018 - 2024). His research focuses on the development and characterisation of translational biomaterials. He has expertise in the synthesis of peptides and Raman vibrational probes, hydrogel design, 3D printing, and materials and chemical characterisation. He was previously involved in the UK Regenerative Medicine Program for Smart Materials and in 2020 was awarded a CAS Future Leaders Fellowship.
Department of Systems Engineering, École de Technologie Supérieure, Montreal, Quebec.
Presentation Title: Kinematic assessment of the knee joint (Session 2: Biomechanics and Sports Medicine). Abstract: In this presentation, we will present the research that has been published in the last ten years on the use of an innovative piece of technology—the knee kinesiography exam. This exam relies on a harness (the KneeKG) attached on the shank and the thigh, which reduces soft tissue artifacts compared to methods using markers glued on the skin. On the harness are fixed optoeletronic markers, whose movements are followed by a portable optoelectronic camera (NDI). The exam consists of a calibration phase, followed by two 45 second walking periods on a treadmill. The system then automatically identifies biomechanical markers on the flexion/extension, ab/adduction and internal/external rotation curves. These markers, known to be related to pain and disease progression, are then translated into patient-specific exercises to be performed at home. Several medium and large cohort studies used the knee kinesiography exam to characterize three-dimensional knee kinematics in a healthy population, in various degrees of knee osteoarthritis, in patients who underwent unicompartmental or total knee arthroplasty and in patients who experienced a ligament rupture. This presentation will summarize the main results issued from these studies, highlighting the clinical usefulness of the technology for managing knee problems.
Prof. Nicola Hagemeister received the M.Sc. degree in biomedical engineering and the Ph.D. degree from the École Polytechnique de Montréal, Montréal, Canada, in 1995 and 2001, respectively. She joined the research center of the Centre hospitalier de l'Université de Montréal (CHUM) as a Researcher in 2002. She obtained an Adjunct Professor position at the École de technologie supérieure, Montréal, in 2003. She is currently a member of the Laboratoire de recherche en imagerie et orthopédie, CHUM. Her research interests are related to gait analysis and the development of tools to assess the quality of orthopaedic or conservative treatments. She is an associate member of the research center of Sacré-Coeur Hospital, Montréal, and an Associate Professor at the Université de Montréal (surgery faculty). Dr. Hagemeister is a member of the SB society (France)
Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
Presentation Title: Assessing Bowling Legality in Cricket: Biomechanical Insights and Implications (Session 2: Biomechanics and Sports Medicine). Abstract: Cricket bowling has traditionally required a rigid arm, with no elbow straightening allowed. However, research shows that maintaining a completely rigid arm is impractical, which has led to rule changes. The current regulations mandate that the elbow's extension angle must not increase by more than 15 degrees. This study aims to determine whether this rule is upheld across various bowlers and styles and to explore if alternative kinematic measures can better distinguish between legal and suspect actions.
Dr. Ferdinands heads many sports biomechanics research programmes at the University of Sydney. In particular, he is a world leading expert in cricket biomechanics. He has developed the first three-dimensional inverse and forward solutions models of bowling in cricket. Dr. Ferdinands also made a major scientific contribution to the justification of the 15-degree elbow extension tolerance to determine bowling action legality by performing the first laboratory studies (with Dr. Kersting) that invalidated the original tiered range of elbow extension angles dependent on bowling speed and spin. Dr. Ferdinands is also the first to examine lower lumbar injury risk factors in fast bowlers with respect to lumbar load kinetics. Dr. Ferdinands is an ex-first class cricketer and professional cricket coach. He is currently editor of the Cricket Coaching Information service for the International Society of Biomechanics in Sports.
Biomaterials Engineering and Nanomedicine
Biomaterials, Drug Delivery and Nanotechnology Unit Head, Center for Biomedical and Biomaterials Research (CBBR), University of Mauritius, Réduit, Mauritius
Presentation Title: Biomaterials addressing health and climate change challenges (Session 3: Biomedical Biomaterials)
Department of Biomedical Engineering, The University of Memphis, Memphis, USA
Presentation Title: Near-field Electrospinning Use in Fabricating the Next-generation Vascular Grafts (Session 3: Biomedical Biomaterials)
Gary L. Bowlin is a Professor and Herbert Herff Chair of Excellence at The University of Memphis in the Department of Biomedical Engineering. Dr. Bowlin’s collaborative and pioneering research focuses on the application of electrospun templates for tissue regenerative applications. Dr. Bowlin’s laboratory has published extensively with over 158 peer-reviewed manuscripts. Google Scholar data shows his group’s published works have been cited over 23,855 times (H-index of 67). Dr. Bowlin has been granted 17 U.S. Patents and over 250 foreign patents. These patents have helped to start five different companies and several commercially available and regulatory agencies cleared products. The latest company, Sweetbio, Inc., is Memphis based and commercializing honey-based wound healing dressings, APIS® and VERIS®. He is a Fellow in the National Academy of Inventors and American Institute for Medical and Biological Engineering. In addition, he is the Inaugural and current President of the International Society for Biomedical Polymers and Polymeric Biomaterials and Treasurer for the International Society for Applied Cardiovascular Biology.
Deparment of Chemical Engineering, University of Leuven, Leuven, Belgium.
Presentation Title: Biopolymers and bio hybrids for health and care (Session 4: Nano-Biotechnology)
I have a dynamic international career with ten-year experience in private sector in Brazil, 14 years as full professor in Chemical Engineering in Finland and since 2019 I am working 100% at KU Leuven in Belgium. I have been serving in management positions both at private sector and universities. I have been advisor for government and organizer of numerous international events. Currently I lead EPNOE, a non-profit organization present in more than 20 countries in Europe. I have moved to Belgium and to KU Leuven to enhance the interdisciplinary aspects of my research. My vision for the following five years is to integrate chemical and biochemical methods to create new sustainable processes and functional materials using biopolymers and biohybrids. Microbial processes, engineering of carriers and encapsulation for human health applications, gels, bioproducts and biofabrication are the research lines that I will be working.
Founding Editor-in-Chief, Bioengineering,
Founding Dean of Engineering, Anderson University SC,
President and Sr. Fellow, AIIMSEI
Presentation Title: Modeling a Multi-modal Biochip for Physiological Status Monitoring in the Triage of Hemorrhagic Trauma and for Allograft Stratification (Session 4: Nano-Biotechnology)
Prof. Dr. Anthony Guiseppi-Elie is an international medical sciences, engineering, and innovation consultant at the American International Institute of Medical Sciences, Engineering, and Innovation. A former Vice President and Chief Academic Officer at Tri-County Technical College. He has 15 years of industrial research and product development experience and 18 years of experience as a tenured, titled, and endowed full professor at universities that include Virginia Commonwealth University, Clemson University, Texas A&M University, and Anderson University, where he was the Founding Dean of the College of Engineering. He has been associated with three startup companies and is Founder, President, and Scientific Director of ABTECH Scientific, Inc. A US citizen who was born in Trinidad and Tobago, he holds the Sc.D. in Materials Science and Engineering from MIT, the M.Sc. in Chemical Engineering from the University of Manchester (UMIST), and the B.Sc. (First Class Honors) in Applied, Analytical, and Biochemistry from the University of the West Indies (UWI). He has published over 225 peer-reviewed journal articles, holds 8 patents, and is a fellow of IEEE, AIMBE, BMES and the RSC. His research interests are in physiological monitoring during hemorrhagic trauma and allotransplantation, polymeric nanobiomaterials in drug delivery and tissue regeneration, and microanalytical systems in the service of human health and medicine.
Detection of Cardiovascular Disorders in Patients Supported with Continuous-Flow Left Ventricular Assist Devices by Monitoring Electrical Current Signals (Session 5: Biosignal Processing). Abstract: Continuous-flow left ventricular assist devices (CF-LVADs) are miniaturised devices implanted in end-stage heart failure patients to support the failing left ventricle. CF-LVADs alter the blood flow in the cardiovascular system, causing further complications. Additional health disorders during CF-LVAD support may increase morbidity and mortality in patients. Therefore, continuously monitoring blood flow through CF-LVADs may help to detect the complications early, allowing for timely interventions and reducing mortality in patients implanted with CF-LVADs. The lack of long-term reliable and implantable sensors in CF-LVADs does not allow for the real-time continuous monitoring of haemodynamic signals in the cardiovascular system. In this study, intrinsic CF-LVAD electrical current signals were continuously monitored and analysed to evaluate cardiac function and detect cardiovascular disorders. CF-LVAD electrical current signal waveforms over a 600 s period in patient-specific RR intervals were analysed to detect normal sinus rhythm, Atrial Fibrillation (AF) with unimodal and bimodal RR interval distributions, and right ventricular failure during CF-LVAD support...(click for more)
Dr. Selim Bozkurt is a Lecturer in the School of Engineering at Ulster University. Before joining Ulster, he worked as a post-doctoral research associate at the Institute of Cardiovascular Science at University College London and at the Craniofacial Unit of Great Ormond Street Hospital for Children. Prior to these roles, he was a researcher in the Department of Mechanical Engineering at University College London. Dr. Bozkurt earned his PhD in Biomedical Engineering from the Eindhoven University of Technology in the Netherlands, where he also worked as a research assistant. He has presented his research as an invited speaker at various conferences and events and has established international academic collaborations with different universities including Texas Tech University in the USA, the National Research Council in Italy, and Yeditepe University and Dogus University in Turkey. Dr. Bozkurt’s research interests include the design, analysis, and testing of implantable medical devices, cardiovascular biomechanics, modelling and simulation of physiological systems to evaluate clinical scenarios, and computational modelling of skull correction in craniosynostosis.
Department of Information Technology and Electrical Engineering, University of Napoli Federico II, Naples, Italy.
Biosignal-based human-machine interfaces: a metrological approach to performance characterization (Session 5: Biosignal Processing). Abstract: One of the cornerstones of the current fifth industrial revolution (also known as Industry 5.0) is its emphasis on human-centricity, which necessitates the development of technologies increasingly tailored to human needs. A pivotal role in this context is played by Human-Machine Interfaces (HMIs), which enable seamless interaction between people and external devices. Beyond conventional tangible interfaces, such as controllers, keyboards, and mice, human-centricity is increasingly integrated into natural interfaces that leverage innate human actions, such as gaze, gestures, or voice and biosignals. In this groundbreaking context, a technically sound performance characterization becomes essential to ensure rapid and reliable transmission of information, particularly important when HMIs are used in critical contexts (such as the medical one). In this talk, a metrology-based approach for assessing the performance of natural HMIs will be presented with particular focus on HMIs based on biosignals. As a case study, two types of natural HMIs will be examined, specifically eye-tracking systems and visually evoked brain signals. These case studies will allow us to evaluate whether a given interface meets the requirements of its intended application, which can be particularly challenging in diverse scenarios ranging from industrial settings to healthcare.
Leopoldo Angrisani is Full Professor of Electrical and Electronic Measurements with the Department of Information Technology and Electrical Engineering of the University of Naples Federico II, Italy. He is also Chair of the Board of the Ph.D. Program ICTH - Information and Communication Technology for Health of the University of Naples Federico II. His research focuses on the role of measurement in the IoT field and, more generally, in the Industry 4.0 and Health 4.0 fields, cyber-physical measurement systems, measurement of ICT systems sustainability and sustainability of measurements, sensors, sensor networks, and measurement methods in precision agriculture and livestock farming, operation and performance assessment of communication systems, equipment, and networks, measurement uncertainty, impact of quantum technologies on measurements. He is currently the Coordinator of the Technical/Scientific Committee of MedITech – one of the eight Italian Competence Centers on I4.0 enabling technologies. He is Fellow of IEEE. He has chaired the IEEE Instrumentation & Measurement Society Italy Chapter since 2015. This chapter has received many awards, including the prestigious "Chapter of the Year 2021"award by the IEEE Region 8 (Europe, Middle Est, Africa). In 2021, he was awarded the “2021 IEEE Instrumentation and Measurement Society Technical Award” “For contributions in the advancement of innovative methods and techniques for communication systems test and measurement”. (H-index = 36; citations = 5208).
School of Biomedical Engineering, UPC-Peruvian University of Applied Science, Lima, Peru.
Presentation Title: Functional Materials to Obtain Smart Microrobotics for Diagnostic and Therapy (Session 6: Biochemical Engineering). Abstract: Medical microrobots exhibit promise in acting as carriers for cancer cell therapy, effectively delivering drugs, and as manipulators equipped for biosensing, offering mobility and adaptability. These small robots are built using a combination of functional nano and micro-materials. The key to obtaining robots with multiple abilities lies in the precise combination of these materials. However, these materials have to be biocompatible with living systems. Herein, I will provide a comprehensive overview of different microrobots used for several biomedical applications. Focusing on the material composition for propelling, drug carrier, and mobile platform for sensing systems. In addition, their unique physical and chemical, mechanical, and optical, properties have been used to integrate into microrobots capable of achieving greater programmability to reach difficult access spaces and work in collective behaviors to ensure the desired task. Finally, the intricate challenge of creating a microrobot that integrates various physical and chemical functionalities will be demonstrated. These promise medical microrobots act as carriers for cancer cell therapy, effectively delivering drugs to eradicate bacterial biofilms and as manipulators equipped for biosensing. This innovative concept, revolutionizing the landscape of programmed robotics with multifaceted chemical and physical intelligence just using functional micro and nanomaterials.
Dr. Carmen Mayorga, currently is a professor at the School of Biomedical Engineering, UPC-Peruvian University of Applied Sciences previously she was a senior scientist at the Technical University of Ostrava and led the Kralupy unit from the Centre for Advanced Functional Nanorobots, UCT-Prague. She was a research fellow in the nanobioelectronics and biosensors group/ICN2, Barcelona-Spain, and at Nanyang Technological University, Singapore. Currently, her main research fields include the development of bio/sensors based on 2D-materials platforms functionalized with bioreceptors (enzyme, DNA, and antibodies) as well as micro/nano robotics at different scales and different propulsion modes for biomedical applications and environmental monitoring. Moreover, she is also interested in 2D-materials catalysis for energy applications.
Department of Physical and Analytical Chemistry, University of Oviedo, Spain.
Development of bioelectrochemical platforms for decentralized and low-cost analysis of molecules of interest in clinical, food or environmental fields.
Prof. M. Teresa Fernández Abedul obtained her Ph.D in Chemistry in 1995, from the University of Oviedo (Spain). She was awarded with pre- and post-doctoral Scholarships under the supervision of Prof. Wilson at Kansas University and Prof. Heineman at the University of Cincinnati. She directed her research to the field of bioelectroanalysis and, later on, to the integration with microchip electrophoresis. In 1994 she obtained an Assistant Professorship in the Department of Physical and Analytical Chemistry of the University of Oviedo, becoming Associate Professor in 2002. At this moment, she has been credited by the Spanish Ministry of Economy and Competitiveness for Full Professorship. Her interest in the development of low-cost microfluidic devices led her to visit and work during last summers with the group of Prof. Whitesides at Harvard University, maintaining nowadays a continuous and fruitful collaboration. At this moment, her research is devoted to the integration of a sensitive electro(bio)analytical detection on miniaturised devices (paper, thread, polymeric microchips…) using different low-cost mass-produced materials (pins…) and highly-sensitive electrode configurations (interdigitated, microfluidic electrodes…) as well as surface nanostructuration and use of highly-detectable molecules (nanoparticles and nanovesicles).
Invited Speakers
Prof. Dr. Gulden Camci-Unal
Department of Chemical Engineering Emerging Technologies & Innovation Center (ETIC), University of Massachusetts Lowell, Lowell, USA.
Talk: Unconventional Biomaterials for Tissue Engineering and Regenerative Medicine. Abstract: Regeneration of tissues damaged due to disease, trauma, degeneration, and aging represents a major medical need. Although surgical replacement can be performed to address this issue, insufficient number of donors limits the applicability of the approach. There is an unmet demand for development of tissue replacements. My work at the interface of biomaterials and biomedical engineering has made important contributions in generation of engineered biomaterial platforms through my multidisciplinary research background. To achieve my research goals, I use diverse tools from chemistry, cell biology, materials science, engineering, and medicine. In this seminar, I will talk about the functional biomaterials that we developed using unconventional approaches to generate tissue-mimetics for clinical applications. We developed multicellular and compartmentalized scaffolds for regenerative engineering, hydrogel-based platforms for personalized medicine, bioactive scaffolds for template-guided biomineralization, oxygen-generating biomaterials for tissue repair, micro/nanoparticle-reinforced hydrogels and origami-inspired approaches for bone tissue engineering, and hydrogel-based stem cell delivery approaches. I will also talk about my lab’s expertise on developing point of care (POC) diagnostic platforms for detection of pathogenic diseases (viral and bacterial), health conditions, forensic applications, and testing for environmental reagents. To overcome the limitations with the conventional methods, we develop rapid, portable, and reliable platforms for POC diagnostics. My lab’s research projects cover a broad range of applications including understanding fundamental biology to developing disease models for personalized medicine, tissue repair and regeneration, and rapid POC diagnostics. The overarching goal of my research is to improve human health and quality of life.
Prof. Dr. Franz Konstantin Fuss
1. Chair of Biomechanics, Faculty of Engineering Science, University of Bayreuth, Bayreuth, Germany 2. Division of Biomechanics, Department of Biomechatronic Systems, Fraunhofer Institute of Manufacturing Engineering and Automation IPA, Stuttgart, Germany
Talk: Dynamic balance diagnostics with smart insoles
Dr. Daria Podstawczyk
Department of Process Engineering and Technology of Polymer and Carbon Materials, Faculty of Chemistry, Wroclaw University of Science and Technology, Wrocław, Poland.
Talk: Coaxial 4D Printing of Thermoresponsive Hydrogel Soft Bioactuators with Embedded Perfusable Channels. Abstract: Most soft actuators have bimorph and planar structures, which allow them to deform only in the linear direction, e.g., bending. Recently, more attention has been paid to advanced, three-dimensional actuators with patterned structures and complex motions (1). A promising method for more precisely controlling material architecture involves the use of 4D printing technology. 4D printing is an emerging fabrication technology that offers precise manufacturing with great potential in various engineering applications, including soft biorobots. It enables the creation of dynamic and responsive structures using 3D printing techniques and materials capable of changing shape over time (the fourth dimension). Here, we focus on the swelling/deswelling phenomena in thermoresponsive hydrogels as the driving force for changing material shape in response to stimuli. We developed a protocol for producing new advanced functional PNIPAAm-based biomaterial inks for coaxial 4D printing of biomaterials. These biomaterials have a geometrically designed internal microstructure and architecture, capable of reversibly expanding and contracting in response to temperature changes (2). This was achieved by designing oriented microstructures and patterned macrostructures with perfusable channels embedded within the 4D-printed hydrogel (3). We also investigated the physics of anisotropy of the printed hydrogel and conducted physicochemical, rheological, and mechanical characterization of the functional inks and 4D-printed objects. This confirmed the interrelation between material properties and shape morphing behavior.
Dr. Andrew Robbins
Department of Mechanical Engineering, University of Texas at Tyler, Tyler, USA.
Talk: Learning how Sheep Move: Developing a General Inverse Kinetic Model for Sheep. Abstract: Introduction: Whole body inverse kinetic models of humans are well developed. However, for animal models of human disease, the prevalent tools in human biomechanics do not exist. This work explores the development of whole body biomechanical models of quadrupeds, and presents preliminary results in the development of a whole body biomechanical model for sheep in OpenSIM, for use with motion capture data. We present statistical and machine learning models for predicting the hip joint centers from anatomical measurements and landmarks, as well as models for predicting the mass and inertial properties of sheep body segments. Methods: CT scans from 16 sheep of varying ages, weight, sex, and phenotypes were acquired and the data used to calculate the known hip joint center by sphere fitting the femoral head. Anatomical measurements and additional subject information were used to create models to estimate the hip joint centers in absence of CT data. Then, the mass and moments of inertia for each body segment were estimated from the CT scans, and predictive models applied in the absence of CT scans. Results: Hip joint centers were predicted with much greater accuracy than previous methods, with errors on the order of a few millimeters, depending on the animal. Mass and inertial properties were predicted with less accuracy, with errors typically within 10%, but in some cases exceeding 20%. Conclusions: This work represents a significant new set of data for biomechanical models of sheep, being the first comprehensive study to include data from multiple animals. However, our data set is still limited, and would significantly benefit from a larger set of animals to be included. Additionally, sensitivity analysis on the models produced using this data will need to be performed to determine the extent to which errors in the various parameters affect final kinetic analyses.
Prof. Dr. Michael Moreno
Department of Mechanical Engineering, J. Mike Walker ’66 Faculty, Texas A&M University, Texas, USA.
Talk: Learning how Sheep Move: Developing a General Inverse Kinetic Model for Sheep. Abstract: Introduction: Whole body inverse kinetic models of humans are well developed. However, for animal models of human disease, the prevalent tools in human biomechanics do not exist. This work explores the development of whole body biomechanical models of quadrupeds, and presents preliminary results in the development of a whole body biomechanical model for sheep in OpenSIM, for use with motion capture data. We present statistical and machine learning models for predicting the hip joint centers from anatomical measurements and landmarks, as well as models for predicting the mass and inertial properties of sheep body segments. Methods: CT scans from 16 sheep of varying ages, weight, sex, and phenotypes were acquired and the data used to calculate the known hip joint center by sphere fitting the femoral head. Anatomical measurements and additional subject information were used to create models to estimate the hip joint centers in absence of CT data. Then, the mass and moments of inertia for each body segment were estimated from the CT scans, and predictive models applied in the absence of CT scans. Results: Hip joint centers were predicted with much greater accuracy than previous methods, with errors on the order of a few millimeters, depending on the animal. Mass and inertial properties were predicted with less accuracy, with errors typically within 10%, but in some cases exceeding 20%. Conclusions: This work represents a significant new set of data for biomechanical models of sheep, being the first comprehensive study to include data from multiple animals. However, our data set is still limited, and would significantly benefit from a larger set of animals to be included. Additionally, sensitivity analysis on the models produced using this data will need to be performed to determine the extent to which errors in the various parameters affect final kinetic analyses.
Prof. Dr. Seda Kizilel
College of Chemical & Biological Engineering, Koç University, Istanbul, Turkey.
Talk: Designing immunologically invisible spheroids using biomaterials, genetic engineering and machine learning. Abstract: One of the main obstacles in cell transplantation is the need for immunosuppressive drugs to prevent rejection. These medications carry risks, including increased susceptibility to infections and systemic immunosuppression. In addition, the availability of donor islet cells is limited, making it difficult to scale up this treatment option. To address these challenges, we are exploring innovative strategies to enhance the function of implanted cells such as insulin secreting islets. One approach involves the development of biomaterials that can shield transplanted islets from immune attack while still allowing for the exchange of essential nutrients and signaling molecules. The other one that we use involves machine learning, where we use artifical neural network modeling algorithms to predict the permeability and crosslink density of the biomaterials that we use to shield transplanted cells. The last strategy is the use of genetic engineering where the genome of the cells can be edited to render them "invisible" to the immune system, reducing the risk of rejection and improving long-term outcomes. We aim to create a protective barrier around transplanted islet cells while simultaneously enhancing their immune tolerance thorugh genetic manipulations. Our approach holds promise for improving the efficacy and durability of islet transplantation as a treatment for many diseases that involve cell transplantation, including type 1 diabetes.
Dr. Hana Lísalová
Department of Optical and Biophysical Systems, Division of Optics, FZU - Institute of Physics of the Czech Academy of Sciences, Prague, Czechia.
Talk: Advancing Cell-on-a-Chip Interfaces with Bio-functional Terpolymer Nano-Brushes Exhibiting Strong Resistance to Bacterial Adhesion. Abstract: Bioengineering plays a crucial role in developing advanced biomedical devices and interfaces that integrate biological systems. One major challenge in the development of cell-on-a-chip interfaces is preventing bacterial contamination while maintaining cellular compatibility. Low-fouling, (super-)hydrophilic zwitterionic polymer materials have emerged as potential biomedical materials and bio-functional coatings. Here, we report a novel terpolymer nano-brush coating that effectively suppresses undesired biomolecular fouling and biofilm formation while providing a sufficient molecular functionalization capacity.
Dr. Eduardo Espinoza
Department of Inorganic Chemistry and Chemical Engineering, University of Cordoba, Cordoba, Spain.
Talk: Biopolymers and 3D Bioprinting
Ms. Daniela Pedrozo Roca
INBIO, Faculty of Engineering, National University of San Juan, San Juan, Argentina.
Talk: Functional Characterization of Brain Areas Using Functional Magnetic Resonance Imaging. Abstract: Functional magnetic resonance imaging (fMRI) is a non-invasive neuroimaging modality that is continuously growing, both in the clinical and scientific fields. The analysis of these images requires a very complex and varied post-processing of the obtained images. This causes the results of different studies to be non-comparable or difficult to characterize. In order to simplify the processing and obtain objective results with analyzable metrics, this work proposes the development of an analysis methodology to obtain statistical values on brain activation areas segmented by region.
Prof. Dr. Silviya Petrova Zustiak
Department of Biomedical Engineering, SLU Institute for Drug and Biotherapeutic Innovation, Saint Louis University, St. Louis, USA.
Talk: Development of Super-Lubricious Hydrogel Microspheres for the Treatment of Knee Osteoarthritis. Abstract: Osteoarthritis (OA) significantly alters the microenvironment of the knee, increasing inflammation and reducing lubricity. Consequently, OA can result in debilitating pain that necessitates a total joint replacement. Here, we developed super-lubricious hydrogel microspheres to reduce friction and inflammation within the synovium. Hydrogel microspheres were fabricated using polyethylene glycol and subsequently coated with a custom-synthesized copolymer. This copolymer consisted of monomers of dopamine methacrylate (DMA), which provides the microspheres with strong attachment properties, and sulfobetaine methacrylate (SBMA), which provides lubrication due to its zwitterionic nature. The optimization of DMA:SBMA ratios, as well as the copolymers' arrangement (block vs. random copolymer), is currently underway to balance microsphere adhesion and lubricity. Microsphere lubricity was tested using a custom-built tribo-rheometer that enables the quantification of friction coefficients for small sample volumes (140 µL compared to 500 µL for standard tribology set-ups). Copolymer-coated microspheres demonstrated lower friction compared to uncoated microspheres, as well as the synovial fluid derived from patients with varying degrees of osteoarthritis or knee ligament tears. Additionally, the coated microspheres were shown to be injectable, allowing for facile in situ delivery. When injected intra-articularly into the knee capsule of healthy mice, the microspheres persisted for over 10 days and did not cause pain or interfere with daily mice activities. Our current work is focused on loading the microspheres with disease-modifying therapeutic molecules, such as platelet-rich plasma (PRP), and testing those in mice models of OA.
Bioengineering Lectureship Award
Dr. Gianluca Di Flumeri
Department of Molecular Medicine, Industrial Neuroscience Labs, Sapienza University of Rome, Rome, Italy.
TITLE: New frontiers for assessing Human Factor: a bioengineering challenge ABSTRACT: Nowadays, society is increasingly paying attention to the human factor: often, and unfortunately, it is the main cause of disasters and accidents that can cause huge economic damages and human lives. However, adequate and effective solutions to prevent risk situations have not yet been identified, since until now the only possibility was to intervene during the training phase of staff and/or users. Nevertheless, recent technological and scientific progress is providing us with new bioengineering methods and approaches with an enormous potential impact: non-invasive monitoring devices, and even more passive brain-computer interfaces, could be an effective solution to avoid human errors and mitigate the risk associated with the human factor. The presentation aims to inspire discussion on this topic, highlighting the main existing challenges and at the same time exposing some of the recent evidence produced by my experience.
Instructions for Authors
The 1st International Online Conference on Bioengineering will accept abstracts only. The accepted abstracts will be available online on Sciforum.net during and after the conference.
1. Extended deadline for abstract submission: 1̶7̶ ̶J̶u̶n̶e̶ ̶2̶0̶2̶4̶ 17 July 2024
2. Extended deadline for abstract acceptance notification:1̶7̶ ̶J̶u̶l̶y̶ ̶2̶0̶2̶4̶ 17 August 2024. You will be notified of the acceptance of an oral/poster presentation in a separate email.
Abstract submissions should be completed online by registering with www.sciforum.net and Submit Abstract. No physical template is necessary.
1. Your abstract should be include an introduction, methods, results and discussion, and conclusions sections. Abstracts should be 200–300 words in length. Please prepare your abstract in Microsoft Word or another word processing software and then cut and paste the text into the submission portal (see below for more details).
2. Abstract submissions should be completed online by registering [Register] with www.sciforum.net . If you are already registered then please Login to Submit Abstract.
3. All accepted abstracts will be published as part of a single dedicated volume of Engineering Proceedings (indexed within Scopus, ISSN: 2673-4591) after quality check. If you wish to publish a full-length proceedings paper, please refer to the “Publication Opportunities” Section.
4. All abstracts should be submitted and presented in clear, publication-ready English with accurate grammar and spelling.
5. You may submit multiple abstracts. However, only one abstract will be selected for the oral presentation.
6. The abstracts submitted to this conference must be original and novel, without prior publication in any journals or it will not be accepted to this conference.
Detailed Requirements:
1. The submitting author must ensure that all co-authors are aware of the contents of the abstract.
2. Please select only one presenter for each submission. If you would like to change the presenter after submission, please email us accordingly.
3. The presenting author must fill in "Biography" when adding submission authors.
Note: We only accept live presentations.
Template:
(Cut and paste the contents of your abstract into the online portal at Submit Abstract.) Abstract Title: (Total word count: 200-300 words maximum) Introduction: Methods: Results and Discussion: Conclusions: Authors and Affiliations: |
Poster:
- Should include the title, authors, contact details and main research findings, as well as tables, figures and graphs where necessary.
- File format: PDF (.pdf).
- Size in pixel: 1,080 width x 1,536 height–portrait orientation.
- Size in cm: 38.1 width x 54.2 height–portrait orientation.
- Font size: ≥16.
We will reach out to you closer to the dates of the conference with more information.
It is the authors' responsibility to identify and declare any personal circumstances or interests that may be perceived as inappropriately influencing the representation or interpretation of clinical research. If there is no conflict, please state "The authors declare no conflicts of interest." This should be conveyed in a separate "Conflict of Interest" statement preceding the "Acknowledgments" and "References" sections at the end of the manuscript. Any financial support for the study must be fully disclosed in the "Acknowledgments" section.
MDPI, the publisher of the Sciforum.net platform, is an open access publisher. We believe authors should retain the copyright to their scholarly works. Hence, by submitting an abstract to this conference, you retain the copyright to the work, but you grant MDPI the non-exclusive right to publish this abstract online on the Sciforum.net platform. This means you can easily submit your full paper (with the abstract) to any scientific journal at a later stage and transfer the copyright to its publisher if required.
Publication Opportunity
Participants in this conference are cordially invited to contribute a full manuscript to the conference's Special Issue, published in Bioengineering (ISSN 2306-5354, Impact Factor 3.8), with a 20% discount on the publication fee. Details of the special issue will be announced here later. Please note if you have IOAP/association discounts, conference discounts will be combined with IOAP/association discounts. Conference discounts cannot be combined with reviewer vouchers. All submitted papers will undergo MDPI’s standard peer-review procedure. The abstracts should be cited and noted on the first page of the paper.
You are welcome to submit a proceeding paper (3-6 pages) to Engineering Proceedings (indexed within Scopus, ISSN: 2673-4591) after the conference. Publication of the proceedings will be free of charge.
Authors are asked to disclose that it is a proceeding paper of the IOCBE2024 conference paper in their cover letter.
Proceedings submission deadline: 2 December 2024
Carefully read the rules outlined in the 'Instructions for Authors' on the journal’s website and ensure that your submission adheres to these guidelines.
Manuscripts for the proceedings issue must be formatted as follows:
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Title.
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Full author names.
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Affiliations (including full postal address) and authors' e-mail addresses.
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Abstract.
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Keywords.
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Introduction.
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Methods.
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Results and Discussion.
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Conclusions.
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Acknowledgements.
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References.
List of accepted submissions (154)
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sciforum-107337 | Learning how Sheep Move: Developing a General Inverse Kinetic Model for Sheep | , |
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Introduction: Whole body inverse kinetic models of humans are well developed. However, for animal models of human disease, the prevalent tools in human biomechanics do not exist. This work explores the development of whole body biomechanical models of quadrupeds, and presents preliminary results in the development of a whole body biomechanical model for sheep in OpenSIM, for use with motion capture data. We present statistical and machine learning models for predicting the hip joint centers from anatomical measurements and landmarks, as well as models for predicting the mass and inertial properties of sheep body segments. Methods: CT scans from 16 sheep of varying ages, weight, sex, and phenotypes were acquired and the data used to calculate the known hip joint center by sphere fitting the femoral head. Anatomical measurements and additional subject information were used to create models to estimate the hip joint centers in absence of CT data. Then, the mass and moments of inertia for each body segment were estimated from the CT scans, and predictive models applied in the absence of CT scans. Results: Hip joint centers were predicted with much greater accuracy than previous methods, with errors on the order of a few millimeters, depending on the animal. Mass and inertial properties were predicted with less accuracy, with errors typically within 10%, but in some cases exceeding 20%. Conclusions: This work represents a significant new set of data for biomechanical models of sheep, being the first comprehensive study to include data from multiple animals. However, our data set is still limited, and would significantly benefit from a larger set of animals to be included. Additionally, sensitivity analysis on the models produced using this data will need to be performed to determine the extent to which errors in the various parameters affect final kinetic analyses. |
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sciforum-097442 | Non-crosslinked and near-neutral chitosan solution-based mouthwash with efficient antioxidant and antibacterial activity | , |
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Mouthwash, which commonly contains chemical antibacterial agents, is usually used to eliminate oral pathogens and maintain oral health. Herein, we aim to develop a chitosan (CS)-based drug-free mouthwash. CS is known to have great antibacterial activity in acidic conditions, but such acidity is not suitable for practical use, especially in the near-netrual oral environment. The antibacterial activity of CS in the near-neutral conditions is still unknown. In this work, we prepared a near-neutral CS solution-based mouthwash (pH ~6.0) and investigated its antioxidant and antibacterial activity. The CS mouthwash containing 200 μg/mL and 400 μg/mL CS showed a pH value of 6.03 and great antibacterial activity against both Gram-negative Porphyromonas gingivalis and Gram-positive Streptococcus mutans (with a ~90% inhibition rate 3 h after incubation and an inhibition rate of almost 100% at 6 h). The antibacterial effects of CS mouthwash after 3 months show no significant differences compared to those 3 months ago, indicating the consistent and enduring antibacterial properties of CS mouthwash. The pH of the mouthwash also remained stable after 3 mouths. Damaged cell membranes and cell death were observed via SEM, which is considered to be the antibacterial mechanism. In addition, CS mouthwash caused no cytotoxicity to human oral keratinocytes and could protect human oral keratinocytes from damage under H2O2-induced oxidative stress. Also, CS mouthwash demonstrated the great capacity of intracellular ROS scavenging. This is the first report regarding the antibacterial and antioxidant activity of drug-free and near-neutral CS solution-based mouthwash. The oral-tolerated pH and the multiple functions of CS mouthwash give it great potential for clinical use. We will expand the study on the biofilms and compare the efficacy of CS with commercial products in the future. |
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sciforum-097364 | Fish- skin derived collagen as additive in tissue engineering scaffolds |
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Archana Bhaw-Luximon
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Introduction Collagen plays a crucial role in tissue engineering (TE) due to its fundamental properties and widespread presence in the extracellular matrix. In additional to providing structural support to tissues, collagen also contains cell adhesion domains promoting cell growth and differentiation, ideal for TE scaffolds. Fish skin collagen is gaining prominence as a sustainable biomaterial extracted from marine wastes and safe alternative to mammalian collagen due to minimal disease transmission risks, low religious constraints, biocompatibility. and easy biosorption in humans. This study exploits the potential of collagen from Skipjack Tuna fish as a bioactive material for skin TE. Methods The defatting and depigmentation of fish skin were performed in sodium hydroxide and butanol followed by acid soluble collagen extraction in acetic acid, and a precipitation method was conducted using sodium chloride. The sample was dialysed, lyophilised, and characterized. The collagen was further used an additive in hydrogel and electrospun scaffolds. Human dermal fibroblasts (HDFs) and mouse macrophages (RAW 264.7) were grown on the scaffolds with and without collagen and fixed for SEM imaging. Results & Discussion This extraction method yielded 10.02 ± 2.69 % of collagen from fish skin with a high hydroxyproline content of 14.42 ± 0.11 %. The FTIR spectrum showed the presence of amide bands A, B, I, II, and III, and SDS PAGE depicted the presence of α, β, and γ chains pertaining to collagen. SEM images showed the higher proliferation of HDFs on mats containing collagen compared to those without collagen. Collagen did not improve HDFs’ adhesion on hydrogels which proliferated as spheroids. Macrophages adopted an inactivated M0 morphology on collagenous hydrogels compared to an amoeboid shape with pronounced pseudopodia on non-collagenous hydrogels indicative of reduced inflammation in collagen’s presence. Conclusion Overall, while fish-derived collagen was found to improve cell proliferation on electrospun mats, it also reduced inflammatory response in hydrogel scaffolds. |
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sciforum-101068 | The Role of Zinc Metal–Organic Framework (Zn-MOF) in Augmenting Anti-Mycobacterial Drug Action | , , |
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Introduction: Metal–organic frameworks (MOFs) are highly porous networks composed of transition metal ions or clusters coordinated with organic ligands, offering versatile chemical functionalities. While recognized as effective antibacterial agents, their potential against severe pulmonary mycobacterial diseases remains underexplored. This study investigates Zn-MOF as an adjuvant for antimycobacterial drugs, demonstrating its significant efficacy against Mycobacterium smegmatis both alone and in combination with isoniazid and rifampicin. Methods: Zn-MOF was synthesized via solvothermal reaction using Zinc nitrate hexahydrate (Zn2+ ion), 4,4'- bipyridyl (bridge), diphenyl phosphinic acid (organic linker), and dimethylformamide (solvent) at 85°C for 24 hours, yielding a white powder. Physical characterization involved FTIR, Raman, and XRD analyses. Antimycobacterial activity was assessed using a Colony-Forming Unit assay on M. smegmatis, a non-pathogenic model organism to study tuberculosis, evaluating Zn-MOF alone and in combination with isoniazid and rifampicin. Results: FTIR, Raman Spectroscopy, and XRD confirmed the formation of Zn-MOF. The CFU assay demonstrated the superior antimycobacterial activity of Zn-MOF compared to standard drugs. Remarkably, synergistic effects were observed when combined with individual and dual therapies of rifampicin and isoniazid. Conclusion: Zn-MOF shows promise as a novel adjuvant in tuberculosis treatment. Its efficacy against mycobacteria, especially in combination with first-line drugs, suggests its potential for developing innovative drug delivery systems. Understanding its mechanism could pave the way for enhanced therapeutic strategies against tuberculosis. |
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sciforum-100951 | Nitric Oxide-generating plasma-deposited coating for improved cell proliferation and the prevention of biofilm formation | , , |
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Introduction: Nitric oxide (NO) is known to alter coagulation by regulating platelet activity and plays a role in immunological response, infection prevention, and wound repair. Thus, NO-generating coatings have a high potential for wound healing applications. This study selected plasma polymerization to deposit a thin coating because of its high speed and low temperature, controlled film thickness, versatility on various surfaces, and environmental friendliness. Plasma modification offers the unique advantage of selectively enhancing surface properties without affecting the bulk attributes of the materials. Methods: Plasma surface modification was carried out by using the high-frequency plasma system ZP-COVANCE-RFPE-3MP operating at 13.56 MHz at 15 W. Isopentyl nitrite (99.995%), C2H4 (99.95%), and Ar (99.998%) were used as precursors to deposit thin films on silicon wafers and polycaprolactone nanofibers at a pressure below 30 Pa. The obtained plasma-deposited polymer films were studied using SEM, EDX analysis, XPS, FTIR spectroscopy, and WCA. The kinetics of the release of NO were investigated by means of spectrophotometry. The adhesion and proliferation of human fibroblast cells on the surface of plasma-treated samples were studied. The samples were tested against different pathogens in terms of biofilm formation. Results: Plasma deposition resulted in homogeneous and well-bonded layers. SEM micrographs showed no pinholes, cracks, or other damage in the deposited layers. According to FTIR and XPS, the obtained spectra indicated the presence of nitroxyl compounds on the surface of the samples. The difference in wettability of the samples was determined to be ≈90⁰. The deposited polymer coatings were shown to promote better proliferation of human fibroblast cells. The plasma-treated samples completely prevented biofilm formation. Conclusions: An approach was developed for the deposition of nitroxyl-containing films from a mixture of isopentyl nitrite/C2H4 with improved proliferation of human cells and high antipathogenic activity. The research was funded by the Russian Science Foundation (№24-79-10121). |
List of Authors (473)
Event Awards
To acknowledge the support of the conference's esteemed authors and recognize their outstanding scientific accomplishments, we are pleased to announce that the conference will provide multiple awards including MDPI Bioengineering Lectureship 2024 Award, Best Oral Presentation Awards and Best Poster Awards.
The Awards
Number of Awards Available: 1
Nominate your candidate today.
The MDPI Bioengineering Lectureship award:
1. The successful nominee will deliver the MDPI Bioengineering Lecture at the 1st International Online Conference on Bioengineering (IOCBE) on 16-18 October 2024.
2. They will also receive a two year's article processing charge (APC) discounts for any future publications in Bioengineering.
3. They will be granted a travel award of CHF 1,000 CHF with which to attend the World Congress in Bioengineering.
Number of Awards Available: 3
The Best Poster Awards are given to the submission judged to make the most significant and interesting poster for the conference.
There will be three winners selected for these awards.
Terms and Conditions:
Eligible lectureship candidates meet the following criteria:
1.Must be an early-career independent researcher who earned their degree within the last 10 years (doctoral students and postdoctoral scholars in a PI’s lab are not eligible).
2.Must be actively engaged in research in the bioengineering field and have made a noteworthy contribution to the field.
How to nominate:
Sponsors and Partners
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Conference Secretariat
1. Regenerative and Tissue Engineering
Regenerative Engineering is a multidisciplinary platform aiming to facilitate the development of novel technologies towards tissue regeneration as well as de novo biofabrication of living tissues and organs. Stemming from a classical tissue engineering concept (cells, scaffolds, signaling molecules and the microenvironment), regenerative engineering advances into the areas of biomaterials including nanomaterials, drug carriers, bioinks, 3D printing, organoids, microfluidics, microfabrication, bioprocessing, sensors, and personalized medicine. Of particular interest is the application of advanced experimental tools based on machine learning and AI-based methods for disease diagnostics, including cancer, and the computational modeling of the systems’ in vitro and in vivo performance.
Keywords
- Stem cells, cell and gene therapy, and tissue engineering;
- Biomaterials, including bioinspired and biomimetic materials, materials’ functionalization and mechanical testing;
- Drug/gene delivery systems and a controlled release of bioactives;
- Nanomaterials, nanocarriers, and nanoparticle tracking;
- Bioinks, 3D printing, and additive manufacturing;
- Microfabrication, bioprocessing, automation, and scale-up;
- Bioartificial organs, organoids, and organ-on-a-chip technologies;
- Advanced experimental tools, including computational, 3D in vitro and in vivo models;
- Patient-specific therapies and clinical translation.
Session Chairs
Dr. Elena A. Jones, Leeds Institute of Molecular Medicine, School of Medicine, University of Leeds, Leeds, UK
Dr. Dimitrios Kouroupis, Department of Orthopaedics, Miller School of Medicine. University of Miami, Miami, USA.
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2. Biomechanics and Sports Medicine
An interdisciplinary field that integrates principles of scientific research in biomechanics, engineering, and clinical applications aimed at understanding and optimizing human performance, preventing injuries, and promoting recovery in athletes and individuals engaged in physical activity. It includes the mechanical principles of biological systems, e.g., how forces interact with the body during movement and exercise. Contributions may involve the use of motion capture, force plates, and computer simulations to analyze human movement patterns, joint kinetics, muscle function, and the impact of sports equipment on performance. Evidence-based training protocols, injury prevention strategies, and rehabilitation techniques for athletes, workers, and geriatric patients are also welcome. Other topics of interest include the design, test, and validation of equipment and technologies that enhance athletic performance, reduce injury risk, and aid in rehabilitation; specialized equipment such as footwear, protective gear, and orthotic devices that optimize biomechanical efficiency and support injury prevention; advanced materials and technologies like wearable sensors and biomechanical modeling software used to analyze and improve athletic performance and safety; and the intersection of bioengineering with the treatment and prevention of sports-related injuries and conditions, including biomechanical assessments and rehabilitation programs.
Keywords
- Biomechanics;
- Human performance optimization;
- Biological systems;
- Clinical devices;
- Computer simulations;
- Kinetics;
- Training protocols;
- Injury prevention strategies;
- Rehabilitation techniques;
- Wearable sensors;
- Biomechanical modeling software.
Session Chairs
Prof. Dr. Franz Konstantin Fuss, Chair of Biomechanics, Faculty of Engineering Science, University of Bayreuth, Bayreuth, Germany, Division of Biomechanics, Department of Biomechatronic Systems, Fraunhofer Institute of Manufacturing Engineering and Automation IPA, Stuttgart, Germany
Prof. Dr. Michael Moreno, Department of Mechanical Engineering, J. Mike Walker ’66 Faculty, Texas A&M University, USA.
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3. Biomedical Biomaterials
Biomedical biomaterials play a critical role in current and future clinical devices and treatments that improve quality of life after disease or injury. These materials range from natural (i.e., collagen, alginate, silk, and chitosan) to synthetic (i.e., polymers, metals, and ceramics) as well as being bio-absorbable or non-absorbable. This session focuses on the innovations at the intersection of materials science, chemistry, biology, medicine, and engineering that will propel the field into the next generation of biomedical biomaterials and their use in developing forthcoming devices and treatments for clinical use.
Keywords
- Biomedical biomaterials;
- Materials science;
- Bioengineering;
- Clinical devices;
- Bio-absorbable and non-absorbable materials;
- Synthetic materials;
- Polymers;
- Ceramics.
Session Chair
Prof. Dr. Gary L. Bowlin, Department of Biomedical Engineering, The University of Memphis, Memphis, USA
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4. Nano-Biotechnology
“Nanotechnology Applications in Bioengineering” provides a forum for the science of converging technologies, applied to advanced engineering approaches to use in biological processes. As part of nanotechnology, matter is manipulated at the nanoscale (dimensions between 1 and 100 nm) and includes the modification of natural biopolymers and design of synthetic nano-objects (nanoparticles, nanoplates and nanofibers). Of particular interest is the application of new nanotechnological approaches to design nano-structural materials for, e.g., three-dimensional (3D) printing, bioprinting, and tissue engineering, areas with emerging potential in, e.g., food engineering, biology, and medicine.
Keywords
- Synthesis, characterization, production, and applications of biomaterials;
- Surface modifications and their biological effects;
- Cytotoxicity, genotoxicity, immunogenic properties of nanostructured materials;
- New processing methods applied to food engineering;
- Applications in, e.g., tissue engineering, wound dressings, cell models, artificial skin, cancer models, and encapsulation for controlled release.
Session Chair
Dr. Gary Chinga Carrasco, RISE PFI, Høgskoleringen 6b, Trondheim, Norway
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5. Biosignal Processing
Biosignal Processing is a multidisciplinary platform aiming to facilitate the development of novel research, methodologies, software, and hardware systems in the measurement and analysis of signals and images in bioengineering sciences. Emphasis is placed on contributions dealing with the practical, applications-led research on the use of methods, processing strategies, and devices in bioengineering, as well as the application of advanced experimental tools based on machine learning and AI for medical diagnostics and biosignal processing. Contributions may cover broader and specific aspects of biosignals, techniques of processing and analysis, instrumentation, health monitoring and wearable system, rehabilitation and clinical processes, biomedical imaging, image processing and visualization, biosensors, and AI biomedical devices.
Keywords
- Biosignals;
- Biomedical imaging;
- Biomedical engineering;
- Medical diagnosis;
- EEG;
- ECG;
- EDA;
- Speech;
- MRI;
- PET;
- Health monitoring;
- Wearable systems;
- Rehabilitation engineering and clinical engineering;
- Image processing and visualization;
- Biosensor technology;
- Bioelectrical and neural engineering;
- AI biomedical systems;
- Biosensors;
- Devices;
- Lab-on-chip and organ-on-a-chip instrumentation;
- Smart sensing and predictive modelling;
- 4.0-ehanced biomedical systems.
Session Chairs
Dr. Andrea Cataldo, Department of Innovation Engineering (DII), University of Salento, Lecce, Italy
Dr. Egidio De Benedetto, Department of Information Technology and Electrical Engineering, University of Naples Federico II, Naples, Italy.
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6. Biochemical Engineering
Biochemical engineering integrates principles of biology, chemistry, and engineering to develop processes and equipment for the production of materials from biological agents. It focuses on the design and construction of unit processes that involve biological organisms or molecules. The biochemical engineering section also encourages submissions focusing on a wide range of applications, from producing pharmaceuticals and biofuels to treating waste and purifying water, which aim to make these processes more efficient, sustainable, and cost-effective.
Keywords
- Biological systems;
- Cellular processes, enzymatic reactions, and metabolic pathways;
- Genetic engineering;
- Biofuels;
- Chemical process engineering ;
- Bio-based products;
- Bioreactors;
- Process optimization;
- Quality control.
Session Chair
Prof. Dr. Liang Luo, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China
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Submissions
List of Papers (24) Toggle list