ncRNA Webinar | Role of microRNA in Neuroendocrine Neoplasms
the chair
1st Non-coding RNA Webinar
Role of microRNA in Neuroendocrine Neoplasms
Neuroendocrine neoplasms are highly heterogeneous tumors that are incompletely understood at the molecular level. Diagnosis is frequently delayed, pathologic classification can be challenging, and many patients develop non-curable metastatic disease. microRNAs (miRNAs) are small RNA regulatory molecules that negatively regulate gene expression. These molecules are often dysregulated in tumorigenic processes and can also be used as disease biomarkers. Over the past decade, it has become increasingly clear that miRNAs mediate multiple aspects of neuroendocrine neoplasia and have clinical diagnostic utility. In this Special Issue, we focus on clinical, biological, and computational studies of miRNA-mediated gene regulation and dysregulation in all NENs (including lung carcinoids, small cell lung carcinoma, gastroenteropancreatic NENs, Merkel cell carcinoma, medullary thyroid cancer, pituitary adenoma, neuroblastoma, paraganglioma, pheochromocytoma, etc.). A full understanding of miRNA changes in these diverse neoplasms will advance our knowledge of NEN biology and pave the way for novel diagnostic, prognostic, predictive, and therapeutic approaches.
This webinar features several eminent experts in the field of microRNA-mediated gene regulation and neuroendocrine neoplasms.
Date: 9 December 2021
Time: 3:00pm CET | 9:00am EST | 10:00pm CST Asia
Webinar ID: 838 4495 6329
Webinar Secretariat: ncrna.webinar@mdpi.com
Meet Our Speakers
Laboratory of Translational RNA Biology, Department of Pathology and Molecular Medicine, Queen's University, Kingston, Canada;
Neil Renwick is an Associate Professor in Anatomic Pathology and Head of the Laboratory of Translational RNA Biology at Queen’s University. Here, he and his team study microRNA-mediated gene regulation in neuroendocrine neoplasms. Most recently, they have shown that microRNAs can be used to classify neuroendocrine neoplasms and found that miR-375 is a neuroendocrine cell-specific molecule that controls neuroendocrine differentiation and tumorigenesis. Their work indicates that microRNA-mediated gene dysregulation is an important pathomechanism in neuroendocrine neoplasia.
Neuroendocrine neoplasms are highly heterogeneous tumors and cancers that are challenging to diagnose and treat. MicroRNAs are small regulatory RNA molecules that are excellent biomarkers and gateway molecules for understanding disease mechanisms. In this webinar, the chair Prof. Dr. Neil Renwick (Queen’s University), Ms. Jina Nanayakkara (Queen’s University), and Dr. Iacovos Micheal (Sunnybrook Research Institute) share and discuss their latest research on the role of microRNAs in neuroendocrine neoplasms. Specifically, microRNAs are emerging as highly informative clinical markers, reflecting their key regulatory roles in neuroendocrine differentiation, cell plasticity and dedifferentiation, tumor growth and local invasion, and metastasis.
The presentations were followed by a Q&A, moderated by the Chair. The webinar was offered via Zoom and required registration to attend. The full recording can be found here on Sciforum website. In order to stay updated on the next webinars on ncRNA, be sure to sign up for our newsletter by clicking on "Subscribe" at the top of the page.
Guest Editor: Dr. Neil Renwick
Deadline for manuscript submissions: 30 June 2022