Novel 2-Chloro-8-arylthiomethyldipyridodiazepinone Derivatives with Activity against HIV-1 Reverse Transcriptase

Nisachon Khunnawutmanothum; Nitirat Chimnoi; Pornpan Pungpo; Suda Louisirirotchanakul; Supa Hannongbua; Supanna Techasakul

doi:10.3390/ecsoc-10-01422

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Novel 2-Chloro-8-arylthiomethyldipyridodiazepinone Derivatives with Activity against HIV-1 Reverse Transcriptase

Nisachon Khunnawutmanothum

¹,

Nitirat Chimnoi

¹,

Pornpan Pungpo

²,

Suda Louisirirotchanakul

³,

Supa Hannongbua

⁴,

Supanna Techasakul

^{*

1, 4}

¹ Chulabhorn Research Institute, Vibhavadee-Rangsit Highway, Bangkok 10210, Thailand
² Department of Chemistry, Faculty of Science, Ubonratchathani University, Ubonratchathani 34190, Thailand
³ Department of Microbiology, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
⁴ Department of Chemistry, Faculty of Science, Kasetsart University, Bangkok 10903, Thailand

Published: 30 November 2006 by MDPI in The 10th International Electronic Conference on Synthetic Organic Chemistry session Bioorganic Chemistry and Natural Products

https://doi.org/10.3390/ecsoc-10-01422

Abstract: Based on the molecular modeling analysis against Y181C HIV-1 RT, dipyridodiazepinone derivatives containing unsubstituted lactam nitrogen and 2- chloro-8-arylthiomethyl were synthesized via efficient route. Some of them were evaluated for their antiviral activity against HIV-1 RT subtype E and were found to exhibit virustatic activity comparable to some clinically used therapeutic agents.

Keywords: n/a

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