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Preparation of new enantiopure atropisomeric b-aminoalcohols and their use in asymmetric catalysis: enantioselective addition of diethylzinc to aromatic aldehydes.
Published:
11 September 2000
by MDPI
in The 4th International Electronic Conference on Synthetic Organic Chemistry
session General Organic Synthesis
Abstract: A new class of enantiopure b-aminoalcohols having 1,1’-binaphthyl skeleton, and chiral only by atropisomerism, has been prepared and tested as catalytic precursors in the asymmetric addition of diethylzinc to aromatic aldehydes. The aldehydes were quickly and cleanly (99% yield) transformed in the corresponding alcohols with ee up to 87%.
Keywords: b-aminoalcohols, atropisomerism, 1,1’-binaphthyls, diethylzinc.
