(S)-5-(Tosylmethyl)-2-pyrrolidinone: A New Chiral b -Amidosulfone for a Short Asymmetric Synthesis of Indolizidines

Tomas Abellan; Diego Alonso; Jesus Casas; Ana Costa; Carmen Najera; Jose Sansao; Montserrat Varea

doi:10.3390/ecsoc-4-01811

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New Chiral Phase Transfer Supported Catalysts in The Asymmetric Synthesis of a -Amino Acids : The Importance of a Spacer

(S)-5-(Tosylmethyl)-2-pyrrolidinone: A New Chiral b -Amidosulfone for a Short Asymmetric Synthesis of Indolizidines

Tomas Abellan

Diego Alonso

Jesus Casas

Ana Costa

Carmen Najera

^*,

Jose M. Sansao

Montserrat Varea

¹ Departamento de Quimica Organica, Universidad de Alicante. E-03080 Alicante, Spain

Published: 11 September 2000 by MDPI in The 4th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-4-01811

Abstract: The synthesis of (S)-5-(tosylmethyl)-2-pyrrolidinone from (S)-pyroglutaminol [(S)-2-(hydroxymethyl)-2-pyrrolidinone] in three steps and its applications into the synthesis of indolizidines is described in this communication.

Keywords: Asymmetric synthesis, Sulfones, Indolizidines, Dianions, Alkylation

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