Synthesis of Enantiomerically Pure Pipecolic Acid Derivatives via Combination of Biocatalysis and Transition Metal Catalysis

Sape Kinderman; Jetze van Beijma; Larissa Wolf; Hans Schoemaker; Henk Hiemstra; Floris Rutjes

doi:10.3390/ecsoc-4-01816

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Synthesis of Enantiomerically Pure Pipecolic Acid Derivatives via Combination of Biocatalysis and Transition Metal Catalysis

Sape S. Kinderman

¹,

Jetze W. van Beijma

¹,

Larissa B. Wolf

¹,

Hans E. Schoemaker

²,

Henk Hiemstra

¹,

Floris P. J. T. Rutjes

^{*

1, 3}

¹ Institute of Molecular Chemistry,University of Amsterdam Nieuwe Achtergracht 129, 1018 WS Amsterdam, The Netherlands
² DSM Research, Life Science Products P.O. Box 18, 6160 MD Geleen, The Netherlands
³ Department of Organic Chemistry, University of Nijmegen Toernooiveld 1, 6525 ED Nijmegen, The Netherlands

Published: 11 September 2000 by MDPI in The 4th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-4-01816

Abstract: The combination of biocatalysis and transition metal catalysis provides a powerful and versatile pathway for the synthesis of multifunctional building blocks. In this approach, the biocatalyst is used to generate enantiomerically pure starting materials, while transition metals are used in a catalytic fashion for further synthetic elaboration.

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Sape Kinderman

Jetze van Beijma

Larissa Wolf

Hans Schoemaker

Henk Hiemstra

Floris Rutjes