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Chemistry of Substituted Quinolinones. V. Synthesis and Utility of Quinolinylphosphazenes in Amination of 8-Methylquinoline
Published:
11 September 2000
by MDPI
in The 4th International Electronic Conference on Synthetic Organic Chemistry
session General Organic Synthesis
Abstract: 2,4-Dihalo-8-methylquinolines 2,3 have been prepared and subjected to azidation and hydrazination reactions showing interesting regioselective properties to give compounds 4-10. The targeted aminoquiolines 13, 14, 15, 17, 19, 22 and 23 were obtained via hydrolysis of their corresponding phosphazenes 11, 12, 16, 18, 20 and 21, respectively. These phosphazenes have been preliminary obtained by condensation of azido and/or tetrazoloquinolines 4, 5, 6, 10, 18 and 22, with triphenylphosphine in either boiling benzene or 1,2-dichlorobenzene.
Keywords: haloquinolines, hydrazinoquinolines, tetrazoloquinolines, azidoquinolines, phosphazenes,
aminoquinolines
