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Chemistry of Substituted Quinolinones. V. Synthesis and Utility of Quinolinylphosphazenes in Amination of 8-Methylquinoline
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1  Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, Cairo 11711, Egypt

Abstract: 2,4-Dihalo-8-methylquinolines 2,3 have been prepared and subjected to azidation and hydrazination reactions showing interesting regioselective properties to give compounds 4-10. The targeted aminoquiolines 13, 14, 15, 17, 19, 22 and 23 were obtained via hydrolysis of their corresponding phosphazenes 11, 12, 16, 18, 20 and 21, respectively. These phosphazenes have been preliminary obtained by condensation of azido and/or tetrazoloquinolines 4, 5, 6, 10, 18 and 22, with triphenylphosphine in either boiling benzene or 1,2-dichlorobenzene.
Keywords: haloquinolines, hydrazinoquinolines, tetrazoloquinolines, azidoquinolines, phosphazenes, aminoquinolines

 
 
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