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One pot Synthesis of Propargylamines using Solid-Phase Extractive Isolation
Published:
11 September 2000
by MDPI
in The 4th International Electronic Conference on Synthetic Organic Chemistry
session Solid Phase Chemistry and Combinatorial Synthesis
Abstract: A library of 42 diverse propargylamines was prepared using a parallel solution phase synthesis approach. The compounds resulting from the Mannich reaction of acetylenes, paraformaldehyde and secondary amines in the presence of copper(I)-chloride were purified by Solid Phase Extraction.
Keywords: propargylamines, Mannich reaction, library, Solid Phase Extraction
