Synthesis of the pyrido[2,3,4-kl]acridine ring system common to several cytotoxic marine alkaloids

Eva Pascual-Alfonso; Carmen Avendaño; J. Menéndez

doi:10.3390/ecsoc-4-01913

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Synthesis of the pyrido[2,3,4-kl]acridine ring system common to several cytotoxic marine alkaloids

Eva Pascual-Alfonso

Carmen Avendaño

J. Carlos Menéndez

¹ Departamento de Química Orgánica y Farmacéutica, Facultad de Farmacia. Universidad Complutense, 28040 Madrid, Spain.

Published: 11 September 2000 by MDPI in The 4th International Electronic Conference on Synthetic Organic Chemistry session Bioorganic Chemistry and Natural Products

https://doi.org/10.3390/ecsoc-4-01913

Abstract: An efficient five-step synthesis of the pyrido[2,3,4-kl]acridin-8-one system is described, using a Suzuki coupling of a 4-iodoquinoline and a oxidative demethylation with cobalt trifluoride as the key steps.

Keywords: n/a

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Eva Pascual-Alfonso

Carmen Avendaño

J. Menéndez