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Hyperandrogenism in adolescent girls - does serum androgen concentration may be related to macronutrient intake?
* 1 , 2 , 3 , 4 , 4
1  Department of Dietetics, Poznan University of Physical Education, Poznan, Poland
2  Department of Perinatology and Gynecology, Division of Developmental Gynecology and Sexology, Poznan University of Medical Sciences, Poznan, Poland
3  Department of Computer Science and Statistics, Poznan University of Medical Sciences, 60-806 Poznan, Poland
4  Department of Pediatric Dentistry, Chair of Pediatric Dentistry, Poznan University of Medical Sciences, Poznan, Poland
Academic Editor: Iris Wu (registering DOI)

The cause of hyperandrogenism in adolescent girls, typical for polycystic ovary syndrome (PCOS) is still not fully understood.

The aim of the study was to check whether there is a correlation between macronutrient intake and testosterone, androstenedione, dehydroepiandrosterone-sulfate ( DHEA) and the sex hormone binding globulin (SHBG) serum concentration in adolescent girls.

The study included 96 Caucasian girls aged 13-18 years: 61 girls with PCOS and 35 healthy girls. A fasting blood sample was obtained for measurement of serum DHEA-S, SHBG, total testosterone and androstenedione. Macronutrient intake was assessed using the three-day food record method.

Our research indicates that the hypothesis of a relationship existing between macronutrient intake in girls in the peripubertal period and serum androgen concentration is true for dietary fat, protein and fiber consumption. There was a significant positive correlation between total fat, monosaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA), and testosterone and androstendione, and between saturated fatty acids (SFA) and testosterone. Fiber showed a negative correlation with the concentration of androstendione. SHBH concentrations showed a positive correlation only with total dietary protein.

Keywords: adolescents; adolescent girls; hyperandrogenism; polycystic ovary syndrome; macronutrients; diet; nutrition