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Aqueous Synthesis of 2-Amino-tetrahydrobenzo[b]pyrans by a Green, Efficient and Simple Organocatalyst
Abstract: An efficient and convenient method has been developed for the synthesis of 2-amino-4H-tetrahydrobenzo[b]pyrans derivatives via one-pot , three-component condensation of malononitrile or ethyl cyanoacetete, dimedone and different aldehydes in the presence of a catalytic amount of potassium phthalimide-N-oxyl (POPINO), as a new organocatalyst, in aqueose media. A variety of 2-amino-tetrahydro[b]pyrans derivatives were obtained in high to excellent yield within short reaction times.
Keywords: Multicomponent reaction, dimedone, on water synthesis, 2-amino-4H-tetrahydrobenzo[b]pyrans, potassium phthalimide-N-oxyl.