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Studies of DNA Interactions with Functionalizedbenzo[a]phenoxazinium Chlorides
Published: 30 October 2012 by MDPI in The 16th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis
Abstract: A new series of water-soluble benzo[a]phenoxazinium salts mono- or disubstituted with 3-chloropropyl groups at the amine of position 9, and also at the hydroxyl function of position 2, were synthesized. The interaction of these compounds with DNA phosphate was investigated. It was found that the functionalized terminal has a dramatic influence on the type of interaction with the amino group at the 9-position greatly promoting intercalation.
Keywords: Benzo[a]phenoxazines, DNA interactions, intercalation, photophysical studies