Studies of DNA Interactions with Functionalizedbenzo[a]phenoxazinium Chlorides

B. Rama Raju; M. Sameiro T. Gonçalves; Paulo J. G. Coutinho

doi:10.3390/ecsoc-16-01116

x Selected file doesn't exist!

Previous Article in event

Aqueous Synthesis of 2-Amino-tetrahydrobenzo[b]pyrans by a Green, Efficient and Simple Organocatalyst

Previous Article in session

Synthesis, Molecular Docking Studies and Anti-mycobacterial Evaluation of N-(Malon-substituted-anilic)-4-phenyl Thiosemicarbazide

Next Article in event

Synthesis and Photophysics Behaviour in AOT/cyclohexane w/o Microemulsions of a New Benzo[a]phenoxazinium Chloride with 3-((3-chloropropyl)disulfanyl)propyl)Amino Group

Studies of DNA Interactions with Functionalizedbenzo[a]phenoxazinium Chlorides

B. Rama Raju

^{1, 2},

M. Sameiro T. Gonçalves

¹,

Paulo J. G. Coutinho

^{*

1}

¹ Centro de Física, Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal
² Centro de Química, Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal

Published: 30 October 2012 by MDPI in The 16th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-16-01116

Abstract: A new series of water-soluble benzo[a]phenoxazinium salts mono- or disubstituted with 3-chloropropyl groups at the amine of position 9, and also at the hydroxyl function of position 2, were synthesized. The interaction of these compounds with DNA phosphate was investigated. It was found that the functionalized terminal has a dramatic influence on the type of interaction with the amino group at the 9-position greatly promoting intercalation.

Keywords: Benzo[a]phenoxazines, DNA interactions, intercalation, photophysical studies

View paper

44 Reads
0 Recommendations

B. Rama Raju

M. Sameiro T. Gonçalves

Paulo J. G. Coutinho