Objective To investigate the relationship between the outcome of in vitro fertilization and embryo transfer (IVF-ET) and the visceral fat area (VFA). Methods From January 2019 to December 2019, the Reproductive Center of the First Hospital of Lanzhou University was selected from the IVF patients who were under 38 years old, the number of follicles was 7-15, and the AMH was 1.1-9, and polycystic follicles were excluded. Patients with endocrine disorders such as PCOS and hyperthyroidism and hypothyroidism were divided into two groups according to VFA values. The prospective cohort was used to analyze the relationship between visceral fat content (VFA) and IVF assisted pregnancy outcomes. Patients were divided into three groups according to VFA: the first group (VFA≤50cm2), the second group (50 cm2 <VFA≤70 cm2), and the third group (VFA> 70 cm2). Result There were statistically significant differences in the number of infertility years (P = 0.033), total propulsion (P = 0.019), and clinical pregnancy rate (X2 = 396.0, P <0.001) in different VFA groups: patients with VFA> 70 cm2 The number of years of infertility increased significantly, and the total amount of propulsion increased significantly; the clinical pregnancy rate of VFA ≤50cm2 decreased significantly; the time of down-regulation (P = 0.762), number of down-regulations (P = 0.535), Total amount of adjustment (P = 0.378), time to promote ovulation (P = 0.285), E2 of trigger day (P = 0.130), number of eggs obtained (P = 0.953), number of cleavages (P = 0.415), high quality embryo rate ( P = 0.149). Conclusion Increasing or decreasing visceral fat area (VFA) affects IVF-ET clinical medication and fertility outcomes.