Immunomodulators help to maintain immune-system homeostasis, thereby acting as prophylactic and immunotherapeutic agents for several diseases. The increasing side effects associated with the use of synthetic immunomodulators have necessitated the search for an alternative remedy. This study investigated the immunomodulatory potential of the methanol extracts of epiphytic Loranthus micranthus from two host plants: Guajava and Parkia biglobosa. The phytochemicals, cell-mediated, and humoral immune responses were determined using standard methods. The result of the phytochemical screening shows that both extracts contain flavonoids, alkaloids, tannins, steroids, glycosides, saponins, carbohydrates, reducing sugar and cyanogenic glycosides in varying quantities, with the loranthus micranthus harvested from psidium guajava containing a higher quantity of the phytoconstituents. The extracts were found to be safe up to a dose of 5000 mg/kg body weight and elicited a significant (P < 0.05) increase in total leukocyte counts compared with the control. There was a significant (P < 0.05) increase in cell-mediated immunity as evidenced by an increase in edema produced after induction of delayed-type hypersensitivity in treated groups compared with the control. The extracts treated groups just like the standard drug. Levamisole also had an increase in the primary titer values of antibodies when compared to the control. Though the secondary titer value was also higher than the primary titer value, confirming the presence of memory cells after the first challenge. This suggests that the extracts of Loranthus micranthus restore and boost the immune system, hence could be employed as a pharmaceutical agent in the discovery of immunomodulators.