The worldwide Covid-19 pandemic highlighted the importance of developing new generation of sustainable, low-cost and easy accessible bio-antimicrobial agents. The worldwide confusion and pressure on the health care systems, overwhelmed healthcare workers, peaking mortality rates and suffering in emergency rooms traumatized the world population. Enforced isolation, standstill of all normal daily activities, the sudden lack of basic drugs and commodities even in industrial countries left scars in the human mind. There is an urgent need for remedies, known since centuries and available in every household as alternative bioantimicrobials against multidrug resistant ESKAPE pathogens. We prepared formulations of well known microbicides Aloe Vera Barbadensis Miller (AV), Salvia offcinalis (Sage) and iodine (I₂) and stabilized them with polyvinylpyrrolidone (PVP). These biohybrids were tested against 10 pathogens on discs and polyglycolic acid (PGA) surgical sutures by disc diffusion methods. Our bioformulations showed excellent to intermediate inhibitory action against our selection of microorganisms on discs and sutures. AV-PVP-Sage-I₂ biocompounds can be used as low-cost, non-toxic microbicides, disinfectants and agents to stop surgical site infections.