Benedict's Reagent is commonly used in identifying reducing sugars through a redox process where a Cu(I) species is generated. Despite the simplicity of this reaction, this has barely been investigated as a copper (I) source for catalytic processes. In this report, diverse organic azides and alkynes were reacted in presence of catalytic amounts of a Glucose-Benedict Reagent system, obtaining the corresponding 1,2,3-triazoles through a simple and environmentally friendly synthetic procedure.
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Azide-Alkyne Cycloaddition Catalyzed by a Glucose/Benedict Reagent System
Published: 12 November 2021 by MDPI in The 25th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis
Keywords: click chemistry, Benedict reagent, glucose, alkyne, azide, 1,2,3-triazole