Azide-Alkyne Cycloaddition Catalyzed by a Glucose/Benedict Reagent System

¹ Centro Conjunto de Investigación en Química Sustentable UAEM-UNAM, Carretera Toluca-Atlacomulco Km. 14.5, Toluca, Estado de México 50200, Mexico
² Facultad de Ciencias y Educación, Universidad Distrital Francisco José de Caldas. Carrera 7 No. 40B - 53, Bogotá D.C, Colombia
³ Facultad de Química, Facultad de Química, Universidad Autónoma del Estado de México. Paseo Colón esq. Paseo Tollocan, 50120, Toluca, Mexico

Academic Editor: Julio A. Seijas

Published: 12 November 2021 by MDPI in The 25th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-25-11634

Abstract:

Benedict's Reagent is commonly used in identifying reducing sugars through a redox process where a Cu(I) species is generated. Despite the simplicity of this reaction, this has barely been investigated as a copper (I) source for catalytic processes. In this report, diverse organic azides and alkynes were reacted in presence of catalytic amounts of a Glucose-Benedict Reagent system, obtaining the corresponding 1,2,3-triazoles through a simple and environmentally friendly synthetic procedure.

Keywords: click chemistry, Benedict reagent, glucose, alkyne, azide, 1,2,3-triazole

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