Since several decades, our healthcare burden has been increased due to tremendous cases of multidrug-resistant (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) infections especially in tropical countries. In present study, we have synthesized ten hydrazides with the use of greener Chitosan-derived catalyst. This catalyst accomplished the said condensation reaction within 15-30 mins at room temperature conditions. All our synthesized compounds showed stronger affinities against mycobacterium tb and bacterial targets, especially towards 1d7u than the standard drug ciprofloxacin. One of our compounds retained with lower toxicity (electrophilicity index (ω) 3.1304), low chemical hardness (η: 2.1740), and high softness (S: 0.4600). In the realm of development of more potent, effective, safer antituberculosis agents with effective greener synthesis; our current study would provide more insights on potent analogues containing hydrazine motifs in them.