In situ one pot hemi-synthesis of new 2-pyridone derivatives

¹ Laboratoire de Recherche Biotechnologie des Molécules Bioactives et de la Physiopathologie Cellulaire, faculté des sciences de la na-ture et de la vie de l’université de BATNA 2 Algérie
² Université des frères Mentouri-Constantine, Département de chimie, Laboratoire d'Obtention des Substances Thérapeutiques (LOST), Campus Chaabet-Ersas, 25000 Constantine, Algérie
³ Centre de Recherche Scientifique et Technique en Analyses Physico – Chimiques, BP 384, Zone Industrielle Bou-Ismail RP 42004 Bou Ismaïl, Tipaza Algerie
⁴ Université des Frères Mentouri Constantine 1, Unité de Recherche de Chimie de l’Environnement et Moléculaire Structurale CHEMS, 25000 Constantine, Algerie

Academic Editor: Julio A. Seijas

Published: 14 November 2021 by MDPI in The 25th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-25-11724 (registering DOI)

Abstract:

New 2-pyridone derivatives were hemi-synthetised in situ using essential oils of endemic Algerian plants; Ammodaucus Leucotrichus and eucalyptus citriodora as source of chiral aldehydes (perillaldehyde and citronellal respectively). The one pot reaction was carried out in Ethanol including cyanoacetohydrazide, essential oil, and malononitrile.The reaction mixture was catalysed by potassium carbonate. In the present work; two new compounds of highly functionalized 2-pyridones were obtained as privileged medicinal scaffolds.The structures of 2-pyridone derivatives were confirmed by NMR¹H, ¹³C and 2D.

Keywords: one pot ; Essential oil; 2-pyridone; Hemi-Synthesis; NMR analysis.

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