Abstract: Quinoa is a pseudo-cereal that belongs to the pre-Columbian indigenous food habits due to its good nutritional quality and its potential given by an easy development of the crop under different environmental conditions with simple technologies. Pasta replaced with quinoa can represent benefits for consumer health and nutrition, as it will have a better nutritional quality compared to the market pasta with 100% wheat semolina. The effect of pasta consumption with a higher degree of substitution (30%) with quinoa flour "Blanca Aurora Jerico" was explored to determine the potential benefits on cardiovascular risk markers in a healthy population. Anthropometric measurements, dietary assessment, lipid markers of oxidative stress, inflammation and thrombosis were evaluated in a selected healthy population of 10 individuals aged between 25 and 60 years recruited from endocrinology Military Hospital "Dr. Carlos Arvelo "in Caracas, Venezuela, in collaboration with the School of Nutrition and Dietetics at the Central University of Venezuela. Patients with chronic diseases such as diabetes, infections, autoimmune diseases, obesity and people with regular consumption of alcohol or psychoactive substances, pregnant and antiplatelet therapy and antioxidant were excluded. The effect of consumption of pasta in biochemical markers: total cholesterol, HDL and LDL cholesterol, triglycerides, glucose, uric acid, creatinine and insulin in metabolically healthy population were no statistically different for any of these markers before and after intake substituted quinoa pasta. According to these results, the ingestion of pasta does not influence the evaluated parameters and can be advised for special diet regime.