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Pyrazinecarboxamides, Their Synthesis and Evaluation as Potential Herbicides
Published: 27 November 2008 by MDPI in The 12th International Electronic Conference on Synthetic Organic Chemistry session Bioorganic Chemistry and Natural Products
Abstract: The condensation of substituted pyrazinecarboxylic acid chlorides with ring substituted anilines yielded nine substituted pyrazinecarboxylic acid amides. The photo-synthesis inhibition activity of a series of pyrazine derivatives was investigated. The synthesis, analytical and biological data of the newly synthesized compounds are presented in this paper. The most active inhibitor of the oxygen evolution rate in spinach chloroplasts was 2-(5-methyl-pyrazine-2-carboxamido)benzoic acid (9, IC50 = 85.0 µmol·L-1).
Keywords: synthesis of pyrazinecarboxamides, photosynthesis inhibiting activity, lipophilicity