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Preliminary Evaluation of Molsidomine Imprinted Polymers
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1  Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1 Str., 02-097 Warsaw, Poland

Abstract: Preliminary results of the recognition and release of molsidomine from molecularly imprinted polymers are reported. The molecularly imprinted polymers (MIPs) were prepared with molsidomine as a template molecule through radical polymerization. Eight different functional monomers were used with ethylene glycol dimethacrylate as crosslinker and dimethylsulphoxide as porogenic solvent. Non-covalent interactions between molsidomine and each functional monomer in DMSO prior to thermal bulk polymerization was utilized. Parallel stationary and dynamic binding experiments on both MIPs and NIPs (non-imprinted control polymers) were applied to verified imprinting process. Prepared polymers bound and remove molsidomine not selectively, but drug release properties were satisfactory.
Keywords: Molecularly imprinted polymers, molsidomine, controlled release