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Synthesis of New 1-Substituted-4-(2-phenylquinazolin-4-yl and 4-ylidene)
* 1 , 2
1  Department of Mathematical and Physical Sciences, Faculty of Engineering,Suez Canal University, Port-Said, Egypt.
2  Centre for Syntheses at Sustainable Conditions and Their Management, Faculty of Science, Masaryk University, Brno, Czech Republic.

Abstract: Two new 1-substituted-4-(2-phenylquinazolin-4-yl and 4-ylidene) thiosemicarbazides 3 and 5 were formed by multistep domino reaction of imidoyl isothiocyanate derivative 1 with 1,1-di-R hydrazine in acetone solution. Applied hydrazine hydrate under the same reaction condition afforded 4-(2-phenylquinazolin-4(3H)-ylidene)-2-(prop-1-en-2-yl)-1- (propan-2-lidene) thiosemicarbazide (7) via six step three component domino reaction. Compounds 3, 5 and 7 were identified by CHNS elemental analysis, 1 H-NMR,13 C-NMR spectral data and their correlation with ones from known structural motives.
Keywords: quinazoline, thiosemicarbazide, domino reaction, hydrogen bond interaction