Synthesis of New 1-Substituted-4-(2-phenylquinazolin-4-yl and 4-ylidene)

Walid Fathalla; Pavel Pazdera

doi:10.3390/ecsoc-11-01298

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Convenient Synthesis of Novel Amino Acid Coupled Benzanilides

Synthesis of New 1-Substituted-4-(2-phenylquinazolin-4-yl and 4-ylidene)

Walid Fathalla

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1},

Pavel Pazdera

¹ Department of Mathematical and Physical Sciences, Faculty of Engineering,Suez Canal University, Port-Said, Egypt.
² Centre for Syntheses at Sustainable Conditions and Their Management, Faculty of Science, Masaryk University, Brno, Czech Republic.

Published: 30 November 2007 by MDPI in The 11th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-11-01298

Abstract: Two new 1-substituted-4-(2-phenylquinazolin-4-yl and 4-ylidene) thiosemicarbazides 3 and 5 were formed by multistep domino reaction of imidoyl isothiocyanate derivative 1 with 1,1-di-R hydrazine in acetone solution. Applied hydrazine hydrate under the same reaction condition afforded 4-(2-phenylquinazolin-4(3H)-ylidene)-2-(prop-1-en-2-yl)-1- (propan-2-lidene) thiosemicarbazide (7) via six step three component domino reaction. Compounds 3, 5 and 7 were identified by CHNS elemental analysis, 1 H-NMR,13 C-NMR spectral data and their correlation with ones from known structural motives.

Keywords: quinazoline, thiosemicarbazide, domino reaction, hydrogen bond interaction

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Walid Fathalla

Pavel Pazdera