Objectives: To analyze the lip and oral cavity (LOC) cancer mortality in relation to chewing tobacco use.

Materials and methods: A correlation study analyzing global trends of the LOC cancer mortality due to chewing tobacco, and the proportion of mortality due to the LOC cancer attributable to chewing tobacco was used.

Results: Among women, the highest proportion of deaths by LOC cancer globally were attributed to chewing tobacco – 27.7% in 2019 (from 21.8% in 1990 ). Among men, the contribution of chewing tobacco to the LOC cancer burden globally has been constant in recent decades (from 13.3% in 1990, to 14.1% in 2019). The percentage of deaths for LOC cancer attributable to chewing tobacco is concentrated in certain world regions, mainly in females in South-east Asia, Africa, Eastern Mediterranean, and Europe, with significantly increasing trends in the last three decades. Except only in Western Pacific region, significatly decreasing trend in the proportion of deaths by LOC cancer in males were observed and were attributed to chewing tobacco in all regions.

Conclusion: Our study noted sex diferences in chewing tobbaco for LOC cancer. Additional analytic epidemiological studies addressing the impact of chewing tobbaco as a risk factor for LOC cancer are needed.