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Stereoselective synthesis of the advanced precursor of (+)-myriocin
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1  P J. Safarik University in Kosice, Faculty of Science, Institute of Chemistry, Debartment of Organic Chemistry, Moyzesova 11, Kosice, Slovak Republic

Abstract: A stereoselective approach toward 2-amino-1,3-propanediol 13 is described. This compound represents the key intermediate in the total stereoselective synthesis of (+)-myriocin 1, an inhibitor of serine palmitoyltransferase (SPT). Moreover, synthon 13 can be used for synthesis of mycriocin analogues. 2-amino-1,3-propanediol moiety is necessary for their biological activity.
Keywords: n/a