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Interaction between pimethixene and human serum albumin
* 1 , 2 , 3 , 3 , 4
1  Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac
2  University of Kragujevac, Institute for Information Technologies, Department of Science, Jovana Cvijića bb, Kragujevac 34000, Serbia
3  University of Kragujevac, Faculty of Medical Sciences, Department of Pharmacy, Svetozara Markovića 69, Kragujevac 34000, Serbia
4  University of Kragujevac, Faculty of Science, Department of Chemistry, Radoja Domanovića 12, Kragujevac 34000, Serbia
Academic Editor: Maria Emília Sousa


Albumin, is the highly abundant protein in the plasma. The main function of protein is delivery various endogenous (fatty acid, vitamins, hormones) and exogenous compounds such as drugs. Further, human serum albumin has a very important role in distribution, free concentration and effectiveness of these compounds.

Pimethixene belongs to the group of antihistamines characterized by sedative and antitussive properties. It has shown remarkable ability to bind to receptors such as serotonin 5-HT2A and 2B, histamine H1 and muscarinic acetylcholine M2. Moreover, oral pimethixene is used to calm dry and irritating coughs in children. However, binding constants of pimetixene for human serum albumin, as the most abundant serum transport protein, have not been determined so far.

Accordingly, in the current study explored the interactions between pimethixene and human serum albumin (HSA) by the spectroscopic measurements (fluorescence spectroscopy and circular dichroism) and molecular docking method.

Keywords: Pimethixene; Human serum albumin; Fluorescence; Circular dichroism
Comments on this paper
Albert Charles
The potential threat to human health posed by sulfamethoxine, an antibiotic drug widely used in agricultural production that can act on humans directly through the food chain, slope unblocked has garnered international attention.