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Coordination compounds of Cu(II) and Ni(II) with 1-(morpholin-4-yl)propane-1,2-dione 4-allylthiosemicarbazone: a protection from free radical damage
* 1 , 1 , 1, 2 , 1 , 3
1  Moldova State University
2  Institute of Zoology
3  Moldova State University, Chisinau, Republic of Moldova
Academic Editor: Alfredo Berzal-Herranz


Free radicals are highly reactive and unstable particles that are produced in the body during normal metabolic functions, or by exposure to toxins in the environment such as tobacco smoke and ultraviolet light. Free radicals have a lifespan of only a fraction of a second, but during that time can damage DNA, sometimes resulting in mutations that can lead to various diseases, including heart disease and cancer. The antioxidants can neutralize the unstable particles, reducing the risk of damage. So the design of new substances as a potent antioxidant is an actual problem in the modern world.

For this purpose it were synthesized coordination compounds of Cu(II) and Ni(II) with 1-(morpholin-4-yl)propane-1,2-dione 4-allylthiosemicarbazone (HL). HL was obtained by the condensation reaction between 1-(morpholin-4-yl)propane-1,2-dione and 4-allylthiosemicarbazide in the ethanol solution. Its structure and purity were proved using 1H and 13С NMR spectroscopy. The coordination compounds were synthesized by the interaction of HL with metal salts in a 1:1 and 1:2 molar ratio. The composition of these compounds was determined using elemental analysis: Cu(L)X (X=Cl-, Br-, NO3-), Ni(HL)2(NO3)2, Ni(L)Cl. These complexes were studied by molar conductivity, IR spectra and X-ray diffraction.

The study of antioxidant activity by the ABTS•+ method showed that the most active compound is Ni(HL)2(NO3)2. Its IC50 value toward ABTS•+ is 19.6 µM, so it is 1.7 times more active than trolox, a water-soluble antioxidant which is used in medicine.

Keywords: antioxidants; coordination compounds; ABTS cation radicals