Substitutions of fluorine atoms and phenoxy groups in the synthesis of quinoxaline 1,4-di-N-oxide derivatives

I. Aldana; S. Pérez-Silanes; B. Solano; A. Burguete; R. Villar; E. Vicente; A. Monge

doi:10.3390/ecsoc-11-01332

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Substitutions of fluorine atoms and phenoxy groups in the synthesis of quinoxaline 1,4-di-N-oxide derivatives

I. Aldana

S. Pérez-Silanes

B. Solano

A. Burguete

R. Villar

E. Vicente

^*,

A. Monge

¹ Unidad en Investigación y Desarrollo de Medicamentos, Centro de Investigación en Farmacobiología Aplicada (CIFA), University of Navarra, 31080 Pamplona, Spain.

Published: 30 November 2007 by MDPI in The 11th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-11-01332

Abstract: The unexpected substitution of fluorine atoms and phenoxy groups linked to quinoxaline or benzofuroxan rings is described. The synthesis of 2-benzyl and 2-phenoxy3-methylquinoxaline 1,4-di-N-oxide derivatives was based on the classical Beirut reaction. The experimental conditions (reaction solvent and catalyst) were explored with the aim of obtaining the target compounds.

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