Previous Article in event
Previous Article in session
Next Article in event
Development and characterization of calcium carbonate-quince bio-composite for pH triggered release of darfenacin hydrobromide in lower GIT: A green chemistry approach
1
,
1
,
*
1
,
*
1
,
1
,
2
,
Muhammad Waqas
3
Academic Editor: Vladimir Uversky
Published:
01 November 2022
by MDPI
in The 2nd International Electronic Conference on Biomolecules
session Biomacromolecules: Carbohydrates
https://doi.org/10.3390/IECBM2022-13373
(registering DOI)
Abstract:
A green chemistry approach was employed to develop gastric pH resistant bio-composites for colon targeted oral delivery of darfenacin hydrobromide. The FTIR, XRD, DSC and TGA results showed good drug-polymer compatibility. The SEM images showed calcite formation in the quince hydrogel system. The drug release of 80% and 34% were observed in a phosphate buffer 6.8 pH and an acidic media, respectively. The restricted drug permeation (approx. 21.8% only) was observed through gastric membrane in an acidic media. The developed formulation significantly inhibited the development of testosterone induced prostatic hyperplasia. No organ toxicity was observed against all the developed formulations.
Keywords: Darfenacine hydrobromide; calcium carbonate-quince bio-composite; green chemistry, benign prostatic hyperplasia; colon targeted delivery system
Muhammad Waqas
