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Synthesis of some new N-acyl derivatives of ferrocenyl pyrazolines and investigation of their cytotoxic effect
* 1 , 2 , 2 , 3, 4 , 5
1  Department of Sciences, Institute for Information Technologies, University of Kragujevac, Jovana Cvijića bb, 34000 Kragujevac, Serbia
2  Department of Biochemistry, Faculty of Medical Sciences, University of Kragujevac, Serbia
3  Department of Microbiology and Immunology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovića 67, 34000 Kragujevac, Serbia;
4  Public Health Institute Kragujevac, Nikole Pašića 1, 34000 Kragujevac, Serbia
5  Department of Chemistry, Faculty of Science, University of Kragujevac, Radoja Domanovića 12, 34000 Kragujevac, Serbia
Academic Editor: Alfredo Berzal-Herranz (registering DOI)

For several years, ferrocene moiety represents a significant part of the structure of different biologically active compounds. Ferrocene is stable and non-toxic compound and as such very useful for various syntheses. The combination of pharmacologically active N-heterocycles with ferrocene mostly leads to a favorable change in biological properties in a huge number of drugs. Considering the importance of these properties, this article describes the synthesis and characterization of a new series of ferrocenyl pyrazolines in good yields. Screening of the new products in vitro against human cervical cancer cells (HeLa), human breast cancer cells (MDA-MB-231), human colon cancer cells (HCT-116), and human fibroblast (MRC-5, as control cells) by the MTT method was performed.

Keywords: cytotoxicity; ferrocene; pyrazolines