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Phytochemical and bioactivity studies from Plectranthus ecklonii
* 1, 2 , * 1, 2 , 2 , 1 , 1, 3
1  CBIOS – Universidade Lusófona’s Research Center for Biosciences & Health Technologies, Campo Grande 376, 1749-024 Lisbon, Portugal.
2  Universidad de Alcalá de Henares. Facultad de Farmacia, Departamento de Ciencias Biomédicas (Área de Farmacología; Nuevos agentes antitumorales, Acción tóxica sobre células leucémicas. Ctra. Madrid-Barcelona km. 33,600 28805 Alcalá de Henares, Madrid, Esp
3  Instituto de Investigação do Medicamento (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, 1649–003 Lisboa, Portugal.
Academic Editor: Alfredo Berzal-Herranz


Plectranthus is a well-known genus belonging to Lamiaceae family and mainly distributed in tropical areas of the globe. Furthermore, Plectranthus species are particularly rich in phenolic compounds and abietane-type diterpenes, such as royleanones, widely used in traditional medicine against a vast range of diseases, including skin disorders and cancer.

In order to study the phytochemical composition and the biological activity of P. ecklonii Benth., ultrasound-assisted extractions were carried out using methanol and acetone as solvents.

It is known from literature data that phenolic compounds are predominant in the methanol extracts, while the phytochemical analysis of the acetone ones from our research group evidenced abietanes as the most occurring secondary metabolites.

Methanol extracts were screened to assay their potential bioactivity as antimicrobials, antioxidants and on skin-related enzymes, as well as their general toxicity. The results showed only a moderate effect against bacteria, but a very promising antioxidant activity, and no relevant general toxicity. Good tyrosinase inhibition was observed, together with an excellent inhibitory activity on collagenase, making the methanolic extract a promising raw material to be used for the development of dermocosmetic formulations, especially those with antiaging activity. Fractionation and further purification were carried out on the acetone extracts, highlighting a significant cytotoxic activity, mainly due to the presence of diterpenes, with an observed IC50 in the low-micromolar range.

Considering the potential applications for internal and topical uses, further studies are currently ongoing on both the extracts to investigate about other relevant biological activities and ascertain their safety.

Keywords: Plectranthus, Lamiaceae, cancer, dermatology, diterpenes, royleanones