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Expedite regioselective synthesis of pyrimidobenzimidazoles
Published: 30 November 2007 by MDPI in The 11th International Electronic Conference on Synthetic Organic Chemistry session Symposium on Microwave Assisted Synthesis
Abstract: An simple, general, efficient and greener method has been developed for one pot regioselective synthesis of pyrimido[1,2-a]benzimidazole is described. Starting from the 2-aminobenzimidazole, malononitrile and carbonyl compound, the methodology involves a ring closure by different ways based on the reaction medium was confirmed by NOE and X-ray studies.